2',5'-Dichloroacetophenone
2',5'-Dichloroacetophenone
CAS: 2476-37-1
Molecular Formula: C8H6Cl2O
2',5'-Dichloroacetophenone - Names and Identifiers
2',5'-Dichloroacetophenone - Physico-chemical Properties
| Molecular Formula | C8H6Cl2O |
| Molar Mass | 189.04 |
| Density | 1.312g/mLat 25°C(lit.) |
| Melting Point | 11-13°C(lit.) |
| Boling Point | 118 °C (12 mmHg) |
| Flash Point | >230°F |
| Solubility | Chloroform (Slightly), Methanol (Slightly) |
| Vapor Presure | 0.0337mmHg at 25°C |
| Appearance | Liquid |
| Specific Gravity | 1.312 |
| Color | Clear yellow to brownish |
| BRN | 1865043 |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | n20/D 1.5624(lit.) |
| MDL | MFCD00000607 |
| Physical and Chemical Properties | Density 1.312 melting point 11-13°C boiling point 118°C (12 mmHg) refractive index 1.5604-1.5624 |
| Use | Used as a pesticide intermediate |
2',5'-Dichloroacetophenone - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | R36/38 - Irritating to eyes and skin. R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S24/25 - Avoid contact with skin and eyes. S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37 - Wear suitable gloves. S23 - Do not breathe vapour. |
| WGK Germany | 3 |
| TSCA | Yes |
| HS Code | 29147000 |
| Hazard Note | Irritant |
2',5'-Dichloroacetophenone - Nature
Open Data Verified Data
colorless to yellowish oily liquid. Melting Point 14 °c. Boiling point 251 ℃, 102~104 ℃(399. 96PA), relative density of 1. 327. Refractive index 5595. Soluble in benzene, ethanol, acetone, insoluble in water.
Last Update：2025-06-10 22:55:16
2',5'-Dichloroacetophenone - Preparation Method
Open Data Verified Data
with p-dichlorobenzene as raw material, in the presence of anhydrous aluminum chloride, heating and melting (60~70 ℃), adding acetyl chloride Dropwise and warming to 110~115 ℃, after 6 hours, then drop to 70~80 ℃, put into cold water, hydrolysis, static stratification, take the lower oily material, wash with hot water, add acid to adjust the pH value to 7~8, vacuum distillation, collect 122~124 C (2. 2605kPa) fraction, that is.
Last Update：2022-01-01 10:42:39
2',5'-Dichloroacetophenone - Application
Open Data Verified Data
The intermediate of pesticide organophosphorus insecticide.
Last Update：2025-08-19 16:24:40
2',5'-Dichloroacetophenone - Safety
Open Data Verified Data
- This product strongly irritates eyes and respiratory tract. Production equipment should be closed, the workshop should be well ventilated, the operator should wear protective equipment, especially wear goggles and masks, gloves and so on.
- tightly sealed in a glass bottle, coated with a barrel or iron drum. Store in a cool, dry, ventilated place, sunscreen, moisture, away from fire, heat source. Light load and light discharge during handling to prevent package breakage.
Last Update：2025-06-10 22:55:16
2',5'-Dichloroacetophenone - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| Application | 2, 5-dichloroacetophenone is a ketone organic substance and can be used as an organic intermediate, such as the preparation of 2, 5-dichlorophenol. |
| Preparation | 2,5-dichloroacetophenone is an organic intermediate, which can be obtained by the Friedel-Crafts reaction of 1, 4-dichlorobenzene. 2, 5-dichloroacetophenone can be used to prepare 2, 5-dichlorophenol. |
| use | as pesticide intermediate |
Last Update：2024-04-10 22:29:15
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