2'-Chloroacetophenone
2'-Chloroacetophenone
CAS: 2142-68-9
Molecular Formula: C8H7ClO
2'-Chloroacetophenone - Names and Identifiers
2'-Chloroacetophenone - Physico-chemical Properties
| Molecular Formula | C8H7ClO |
| Molar Mass | 154.59 |
| Density | 1.190g/mLat 20°C |
| Melting Point | 52-56C |
| Boling Point | 227-230°C |
| Flash Point | 192°F |
| Solubility | Chloroform, DMSO (Slightly), Methanol (Slightly) |
| Vapor Presure | 0.418mmHg at 25°C |
| Appearance | Liquid |
| Specific Gravity | 1.19 |
| Color | Clear light yellow to amber |
| BRN | 1858916 |
| Storage Condition | Store below +30°C. |
| Sensitive | Lachrymatory |
| Refractive Index | n20/D 1.544 |
| Physical and Chemical Properties | Colorless oily liquid. The boiling point of 113 deg C (2.4kPa), the relative density of 1.188, refractive index 1.5438, flash point 83 deg C. Slightly soluble or insoluble in water, can be dissolved in ether. |
| Use | Used as a pharmaceutical Intermediate |
2'-Chloroacetophenone - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R36/37 - Irritating to eyes and respiratory system. R36/37/38 - Irritating to eyes, respiratory system and skin. R26 - Very Toxic by inhalation |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S37/39 - Wear suitable gloves and eye/face protection S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S28A - |
| UN IDs | UN 3416 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | AM6310000 |
| TSCA | Yes |
| HS Code | 29147090 |
| Hazard Note | Harmful/Irritant/Lachrymatory |
| Hazard Class | 6.1 |
| Packing Group | II |
| Toxicity | LD50 orally in Rabbit: 1820 mg/kg |
2'-Chloroacetophenone - Nature
Open Data Verified Data
colorless oily liquid. Boiling point of 113 deg C (2. 4kPa). Density ll88kg/m3. Slightly soluble or insoluble in water, can be dissolved in ether.
Last Update：2025-06-10 22:55:16
2'-Chloroacetophenone - Application
Open Data Verified Data
This product is used for the synthesis of bronchodilator chlorpromazine hydrochloride and other fine chemicals.
Last Update：2025-08-19 16:24:40
2'-Chloroacetophenone - Preparation Method
Open Data Verified Data
- O-nitroethylbenzene method
- O-chlorobenzoyl chloride method to the reactor was first charged with dichloromethane, in which solid anhydrous aluminum trichloride was suspended. An additional aluminum alkyl halide (CH3 )1. 5a IC 11.5 was added. When methylene chloride started to flow, O-chlorobenzoyl chloride was added rapidly, and after the addition, stirring was continued for 1H. The reaction mixture was then poured into water. In this case, the decomposition reaction caused by the exothermic heat causes the methylene chloride to boil. The product was treated by distillation. The dosage of O-chlorobenzoyl chloride was 0. 3mol, (CH3 )1.5 AICl1.5 0.21mol, and the dosage of aluminum trichloride was 0. 1mol. For 1G O-chlorobenzoyl chloride, l ~ lOg dichloromethane was used. The reaction temperature was about 40 °c, and the yield of the product was 98%.
Last Update：2022-01-01 10:42:35
2'-Chloroacetophenone - Safety
Open Data Verified Data
- ingestion, inhalation and exposure to eyes and skin all caused injury. Wear protective gloves, glasses and clothing. Its thermal decomposition of toxic smoke hydrogen chloride.
- 25kg per bucket. Stored at ambient temperature, the container is highly sealed.
Last Update：2025-06-10 22:55:16
2'-Chloroacetophenone - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| introduction | o-chlorophenone is an organic intermediate, which can be oxidized by o-chlorophenone or prepared by Friedel-Crafts acylation from chlorobenzene. |
| use | 2 '-chlorophenyl ethyl ketone is a pharmaceutical and chemical raw material used to prepare chlorobendano and other drugs. It can be prepared from o-chlorinated styrene. This product is used to synthesize the bronchodilator chlorprogenaline hydrochloride (chloropnea) and other fine chemicals. Used as a pharmaceutical intermediate |
| production method | 1. o-nitroethylbenzene method. 2. The o-chlorobenzoyl chloride method first adds dichloromethane to the reactor, in which the suspended solid anhydrous aluminum trichloride. AlCl1.5 was 1.5 by adding alkyl aluminum halide (CH3). When dichloromethane begins to reflux, o-chlorobenzoyl chloride is quickly added. After addition, continue to stir for 1h. The reaction mixture is then injected into the water. At this time, the decomposition reaction caused by exotherm causes methylene chloride to boil. Distilled products. The dosage of o-chlorobenzoyl chloride is 0.3mol,(CH3)1.5 AlCl1.5 0.21mol, and the dosage of aluminum trichloride is 0.1mol. 1g-10g dichloromethane is used for 1g of o-chlorobenzoyl chloride. The reaction temperature is about 40 ℃, and the product yield is 98%. |
| category | toxic substances |
| toxicity classification | poisoning |
| acute toxicity | oral-rat LD50: 1820 mg/kg; Oral-mouse LD50: 880 mg/kg |
| flammability hazard characteristics | thermal decomposition discharges toxic chloride smoke |
| storage and transportation characteristics | warehouse low temperature ventilation and drying |
| fire extinguishing agent | water, carbon dioxide, foam, dry powder |
Last Update：2024-04-09 21:00:56
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