2'-deoxycytidine

2'-deoxycytidine - Names and Identifiers

Name	2'-Deoxycytidine
Synonyms	dCyd deoxycytidine 2'-Deoxycytidine 2'-deoxy-cytidin Cytidine, 2'-deoxy- 2'-deoxycytidine hydrate 2-DEOXYCYTIDINE extrapure 2'-DEOXYCYTIDINE FREE BASE 2'-Deoxycytidine monohydrate Cytosine deoxyribonucleoside cytosine,deoxyribonucleoside Cytosine, 1-(2-deoxy-beta-D-erythro-pentofuranosyl)- 4-amino-1-(2-deoxy-beta-D-threo-pentofuranosyl)pyrimidin-2(1H)-one 4-amino-1-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-pyrimidin-2-one 2(1H)-Pyrimidinone, 4-amino-1-(2-deoxy-beta-D-erythro-pentofuranosyl)- 4-Amino-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one 4-amino-1-[(2R,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2-one
CAS	951-77-9 207121-53-7
EINECS	213-454-1
InChI	InChI=1/C9H13N3O4/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)/t5?,6-,8-/m1/s1

2'-deoxycytidine - Physico-chemical Properties

Molecular Formula	C9H13N3O4
Molar Mass	227.22
Density	1.3171 (rough estimate)
Melting Point	209-211°C(lit.)
Boling Point	368.93°C (rough estimate)
Specific Rotation(α)	59 ° (C=1, H2O)
Flash Point	254.8°C
Water Solubility	Soluble in water, DMSO.
Solubility	H2O: 50 mg/mL, clear, colorless
Vapor Presure	5.47E-12mmHg at 25°C
Appearance	White crystalline powder
Color	White
BRN	87567
pKa	14.03±0.60(Predicted)
Storage Condition	-20°C
Sensitive	Easily absorbing moisture
Refractive Index	59 ° (C=1, H2O)
MDL	MFCD00006547
Physical and Chemical Properties	Melting Point 209-211°C

2'-deoxycytidine - Risk and Safety

Safety Description	24/25 - Avoid contact with skin and eyes.
WGK Germany	3
RTECS	HA3800000
FLUKA BRAND F CODES	10
TSCA	Yes
HS Code	29349990

2'-deoxycytidine - Reference

Reference

1. Liu Zhengbo, Zhang yayuwang, Qiuxia et al. Effects of different potassium levels on the contents of nucleosides in panax ginseng [J]. Journal of Jilin Agricultural University, 2019, 41(4):432-437.
2. Wang, Chengcheng, et al. "Distribution patterns for metabolites in medical parts of wild and cultivated licorice." Journal of pharmaceutical and biomedical analysis 161 (2018): 464-473.https:// doi.org/10.1016/j. Jpba.2018.9/004
3. Engxia Tan et al. [IF = 4.411]. "Quality Evaluation of ophopogonis Radix from Two Different Producing Areas." Molecules. 2019 Jan;24(18):3220

2'-deoxycytidine - Reference Information

NIST chemical information	information provided by: webbook.nist.gov (external link)
EPA chemical substance information	information provided by: ofmpeb.epa.gov (external link)
Use	2 '-deoxycytidine is a deoxyribonucleoside that acts as a modulator of Eg5 kinesin, it has anti-proliferative and apoptosis-inducing activities. 2 '-deoxycytidine (2'-deoxycytidine) is an important pharmaceutical intermediate. Most of them are used to synthesize monomers of deoxynucleotides and prepare Oligodeoxynucleotides, which are widely used in nucleic acid and genetic engineering.
preparation	first α-d-d-deoxyribose (Ⅱ) deoxyribonucleoside (III) was prepared under the catalysis of acetyl chloride, and then the two hydroxyl groups were protected with 4-chlorobenzoyl group to obtain compound V, V and HCl gas were chlorinated in acetic acid solution and recrystallized to obtain compound VI. The uracil is silicified in the presence of ammonium sulfate, and the obtained intermediate VII is directly subjected to a nucleophilic substitution reaction with compound VI to obtain an intermediate VIII of deoxyribonucleoside. Subsequently, VIII is mixed with P-Toluenesulfonyl chloride and acid binding agent, and the obtained suspension is heated with ammonia water to complete the conversion of deoxyribonucleoside to deoxyribonucleic acid cytidine, at the same time, the protective group was removed to obtain the target product 2 '-deoxycytidine (I).
biological activity	2 '-Deoxycytidine, a DEOXY AND glycoside, inhibits the biological activity of Brdu.

Last Update：2024-04-09 20:52:54

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2'-deoxycytidine

2'-deoxycytidine

2'-Deoxycytidine

CAS: 951-77-9;207121-53-7

Molecular Formula: C9H13N3O4

2'-deoxycytidine - Names and Identifiers

2'-deoxycytidine - Physico-chemical Properties

2'-deoxycytidine - Risk and Safety

2'-deoxycytidine - Reference

2'-deoxycytidine - Reference Information

Supplier List

2'-deoxycytidine Request for Quotation

2'-Deoxycytidine

CAS: 951-77-9;207121-53-7

Molecular Formula: C9H13N3O4

2'-deoxycytidine - Names and Identifiers

2'-deoxycytidine - Physico-chemical Properties

2'-deoxycytidine - Risk and Safety

2'-deoxycytidine - Reference

2'-deoxycytidine - Reference Information

Supplier List

2'-deoxycytidine