2-Chloro-2',4'-difluoroacetophenone
2-Chloro-2',4'-difluoroacetophenone
CAS: 51336-94-8
Molecular Formula: C8H5ClF2O
2-Chloro-2',4'-difluoroacetophenone - Names and Identifiers
| Name | 2-Chloro-2',4'-difluoroacetophenone |
| Synonyms | 2-Chloro-2 2-CHLORO-2',4'-DIFLUOROACETOPHEONE 2-Bhloro-2',4'-difluoroacetophenone 2-Chloro-2',4'-difluoroacetophenone Chloromethyl(2,4-difluorophenyl) ketone Ethanone,2-chloro-1-(2,4-difluorophenyl)- [2-(2,4-difluorophenyl)-2-oxoethyl]chloranuide 2,4-difluorophenacyl chloride ,2-chloro-1-(2,4-difluorophenyl)ethanone |
| CAS | 51336-94-8 |
| EINECS | 620-343-5 |
| InChI | InChI=1/C7H6BrF/c1-5-2-3-6(8)4-7(5)9/h2-4H,1H3 |
| InChIKey | UENGBOCGGKLVJJ-UHFFFAOYSA-N |
2-Chloro-2',4'-difluoroacetophenone - Physico-chemical Properties
| Molecular Formula | C8H5ClF2O |
| Molar Mass | 190.57 |
| Density | 1.3544 (estimate) |
| Melting Point | 44-48°C(lit.) |
| Boling Point | 240.9±25.0 °C(Predicted) |
| Flash Point | >230°F |
| Solubility | Chloroform (Slightly) |
| Vapor Presure | 1.07mmHg at 25°C |
| Appearance | Crystalline powder |
| Color | Light Brown Low-Melting |
| BRN | 1943217 |
| Storage Condition | Inert atmosphere,2-8°C |
| Sensitive | Lachrymatory |
| Refractive Index | 1.526 |
| MDL | MFCD00013252 |
2-Chloro-2',4'-difluoroacetophenone - Risk and Safety
| Risk Codes | R34 - Causes burns R37 - Irritating to the respiratory system |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S25 - Avoid contact with eyes. S27 - Take off immediately all contaminated clothing. |
| UN IDs | UN 3261 8/PG 2 |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 10-21 |
| HS Code | 29147000 |
| Hazard Note | Corrosive/Irritant/Lachrymatory |
| Hazard Class | 8 |
| Packing Group | II |
2-Chloro-2',4'-difluoroacetophenone - Introduction
2-Chloro-2 ',4'-difluoroacetophenone(2-Chloro-2 ',4'-difluoroacetophenone) is an organic compound whose chemical formula is C8H5ClF2O.
Nature:
-Appearance: Colorless or light yellow liquid
-Solubility: Soluble in organic solvents such as ethanol, ether and chloroform
-Melting point:-4 ℃
-Boiling point: 104 ℃
-Density: 1.397 g/mL
Use:
2-Chloro-2 ',4'-difluoroacetophenone has many uses in chemistry:
-As an important intermediate in organic synthesis, it can be used to synthesize other organic compounds
-Can be used as raw materials or intermediates in drug synthesis
-In the agricultural field, it can be used as an intermediate for pesticides
Preparation Method:
2-Chloro-2 ',4'-difluoroacetophenone can be prepared in a variety of ways, common methods include the following steps:
1. acetophenone reacts with aluminum chloride to generate α-chloroacetophenone.
2. reacting α-chloroacetophenone with fluorine difluoride to give 2-Chloro-2 ',4'-difluoroacetophenone.
Safety Information:
2-Chloro-2 ',4'-difluoroacetophenone should pay attention to the following safety matters during operation:
-Irritating effect on skin and eyes, rinse with plenty of water immediately after contact.
-use should pay attention to good ventilation conditions, avoid inhalation of its vapor.
-Use protective gloves and goggles to avoid contact with skin and eyes.
-Storage should be sealed and kept away from fire and oxidizing agents.
Nature:
-Appearance: Colorless or light yellow liquid
-Solubility: Soluble in organic solvents such as ethanol, ether and chloroform
-Melting point:-4 ℃
-Boiling point: 104 ℃
-Density: 1.397 g/mL
Use:
2-Chloro-2 ',4'-difluoroacetophenone has many uses in chemistry:
-As an important intermediate in organic synthesis, it can be used to synthesize other organic compounds
-Can be used as raw materials or intermediates in drug synthesis
-In the agricultural field, it can be used as an intermediate for pesticides
Preparation Method:
2-Chloro-2 ',4'-difluoroacetophenone can be prepared in a variety of ways, common methods include the following steps:
1. acetophenone reacts with aluminum chloride to generate α-chloroacetophenone.
2. reacting α-chloroacetophenone with fluorine difluoride to give 2-Chloro-2 ',4'-difluoroacetophenone.
Safety Information:
2-Chloro-2 ',4'-difluoroacetophenone should pay attention to the following safety matters during operation:
-Irritating effect on skin and eyes, rinse with plenty of water immediately after contact.
-use should pay attention to good ventilation conditions, avoid inhalation of its vapor.
-Use protective gloves and goggles to avoid contact with skin and eyes.
-Storage should be sealed and kept away from fire and oxidizing agents.
Last Update：2024-04-09 19:05:50
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