3'-Bromoacetophenone
3'-Bromoacetophenone
CAS: 2142-63-4
Molecular Formula: C8H7BrO
3'-Bromoacetophenone - Names and Identifiers
3'-Bromoacetophenone - Physico-chemical Properties
| Molecular Formula | C8H7BrO |
| Molar Mass | 199.04 |
| Density | 1.505g/mLat 25°C(lit.) |
| Melting Point | 8-11°C(lit.) |
| Boling Point | 79-81°C0.2mm Hg |
| Flash Point | >230°F |
| Water Solubility | Practically insoluble in water |
| Vapor Presure | 0.0165mmHg at 25°C |
| Appearance | Yellow transparent liquid |
| Specific Gravity | 1.498 |
| Color | Clear slightly yellow to yellow |
| BRN | 507599 |
| Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
| Sensitive | Sensitive to light |
| Refractive Index | n20/D 1.576(lit.) |
| MDL | MFCD00000083 |
| Use | It is used as a raw material for organic synthesis and an intermediate for the synthesis of drugs for softening blood vessels. |
3'-Bromoacetophenone - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R36/38 - Irritating to eyes and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 8 |
| TSCA | Yes |
| HS Code | 29147090 |
| Hazard Note | Irritant |
3'-Bromoacetophenone - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| Introduction | 3 '-bromoacetophenone, also known as m-bromoacetophenone, is an organic intermediate that can be used as a raw material by diazotization to form m-acetophenone diazohydrobromide, which is synthesized by Sandmeier reaction. 3 '-Bromoacetophenone can be used to prepare meprotaphenol hydrochloride impurity D and 2-chloro-3'-Bromoacetophenone. |
| preparation | 80ml of 48% hydrobromic acid, 80ml of water and 23g of m-aminophenone are cooled to 0~5 ℃ with ice salt, then the solution prepared by 12.2g of sodium nitrite and 30ml of water is dripped under stirring (under the liquid surface), and the reaction temperature is kept at 0~8 ℃. after dripping, the reaction is continued for 30min. Pour the diazonium salt solution into cold CuBr hydrochloric acid solution (27.5gCuBr + 50ml hydrobromic acid), heat to 50~65 ℃, and fully stir for 2~3 hours. Separate and remove solid matter and water phase to obtain oil. Wash the oil with water until the aqueous solution is neutral. The oil is added to the water and distilled with water steam until there are no oil droplets. The oil layer is separated, and the water layer is extracted with benzene. After the oil layer is merged, benzene is first evaporated at normal pressure, and then the fraction at 117~122 ℃(2.3kp) is collected by vacuum distillation to obtain the product 3 '-bromoacetophenone (31.2g, 99.6% content, 95.2% yield). |
| Use | Used as a raw material for organic synthesis and an intermediate for the synthesis of softening vascular drugs |
Last Update：2024-04-09 02:00:07
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