中文名 | Β-AMINOARTEETHER |
英文名 | Ethanamine, 2-[[(3R,5aS,6R,8aS,9R,10S,12R,12aR)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-yl]oxy]- |
英文别名 | SM934 free base β-Aminoarteether Β-AMINOARTEETHER Ethanamine, 2-[[(3R,5aS,6R,8aS,9R,10S,12R,12aR)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-yl]oxy]- |
CAS | 133162-24-0 |
化学式 | C17H29NO5 |
分子量 | 327.42 |
体外研究 | β-Aminoarteether (SM934;10 µM; 24 hours) treatment directly enhances IL-10 production and suppresses IL-12/23p40 production in primary peritoneal macrophages with IFN-γ stimulation. In vitro, β-Aminoarteether (SM934) could suppress the Th1 and Th17 polarization, but exerted no influence on Treg differentiation. |
体内研究 | β-Aminoarteether (SM934; 1-10 mg/kg; oral administration; daliy; for 3 months) treatment significantly delays the progression of glomerulonephritis and increases the survival rate of NZB/W F1 mice. β-Aminoarteether treatment promots the IL-10 production of macrophages from NZB/W F1 mice. Animal Model: Female NZB/W F1 mice (Six and half months old) Dosage: 1 mg/kg, 3 mg/kg, and 10 mg/kg Administration: Oral administration; daliy; for 3 months Result: Significantly delayed the progression of glomerulonephritis and increased the survival rate of NZB/W F1 mice. |