中文名 | 三(羟甲基)氨基甲烷盐酸盐 |
英文名 | Tri(Hydroxymethyl) Amino Methane Hydrochloride |
别名 | 三氯化氫 三羟基氨甲烷盐酸盐 三羟甲基氨基甲烷盐酸盐 三-(羟甲基)氨基甲烷盐酸 三(羟甲基)氨基甲烷盐酸盐 2-氨基-2-羟甲基-1,3-丙二醇盐酸盐 三(羟甲基)氨基甲烷盐酸盐(Tris HCl) |
英文别名 | Tris.HCl Tris-HCL TRIS·HCL Tris HCL MOLE-READY-TRIS Tris Hydrochloride TRIZMA Hydrochloride SPECTRIS(R) HYDROCHLORIDE SPECTRIS(TM) HYDROCHLORIDE trizmahydrochloride(trishydrochloride) Tris(hydroxymethyl)aminoethane hydrochloride Tris(hydroxymethyl)aminomethane hydrochloride Tri(Hydroxymethyl) Amino Methane Hydrochloride 3-propanediol,2-amino-2-(hydroxymethyl)-hydrochloride 1,3-propanediol, 2-amino-2-(hydroxymethyl)-, chloride 2-Amino-2-(hydroxymethyl)-1,3-propanediol hydrochloride 2-AMINO-2-(HYDROXYMETHYL)-1,3-PROPANEDIOL, HYDROCHLORIDE 1,3-Propanediol,2-amino-2-(hydroxymethyl)-,hydrochloride |
CAS | 1185-53-1 |
EINECS | 214-684-5 |
化学式 | C4H12ClNO3 |
分子量 | 157.6 |
InChI | InChI=1/C4H11NO3.ClH/c5-4(1-6,2-7)3-8;/h6-8H,1-3,5H2;1H/p-1 |
InChIKey | QKNYBSVHEMOAJP-UHFFFAOYSA-N |
密度 | 1.05 g/mL at 20 °C |
熔点 | 150-152℃ |
沸点 | 357℃ at 760 mmHg |
水溶性 | SOLUBLE |
酸度系数 | 8.1(at 25℃) |
PH值 | 2.5-4.0 (25℃, 4M in H2O) |
存储条件 | Room Temprature |
稳定性 | 稳定。与强氧化剂、碱、水分不相容。 |
敏感性 | Easily absorbing moisture |
外观 | 澄清无色 (40% (w/w) H2O) 结晶溶液 |
MDL号 | MFCD00012590 |
危险品标志 | Xi - 刺激性物品 |
风险术语 | R36/37/38 - 刺激眼睛、呼吸系统和皮肤。 |
安全术语 | S26 - 不慎与眼睛接触后,请立即用大量清水冲洗并征求医生意见。 S36 - 穿戴适当的防护服。 |
WGK Germany | 3 |
RTECS | TY2900000 |
FLUKA BRAND F CODES | 3 |
TSCA | Yes |
海关编号 | 29221980 |
下游产品 | 甘氨酸盐酸盐 2,2-二甲基-1,3-二恶烷-5-酮 |
参考资料 展开查看 | 1. 陈威, 关晋平, 匡小慧,等. 多巴胺改性涤棉的静电层层自组装阻燃整理[J]. 印染, 2017(2):11-15. 2. 黄梦明, 田鹏, 刘占奇,等. 新型桂花酒的浸提工艺研究及抗氧化评价[J]. 食品研究与开发, 2019(4). 3. 关晋平, 匡小慧, 唐人成,等. 氯化铁对多巴胺改性蚕丝织物的功能整理[J]. 纺织学报, 2019, 40(02):130-134. 4. 刘小霞, 安学明, 李彦虎,等. 泡制醋蒜抗氧化成分及体外抗氧化能力的测定[J]. 甘肃农业大学学报, 2019(4). 5. 张卜月, 王伟, 叶梅,等. 菁染料与不同构象转铁蛋白相互作用的研究[J]. 广州化工, 2019, 047(017):77-80. 6. 刘姣,曲崇正,谢平金,叶大林,罗臻,梁正辉,陶静,江钢辉.膝骨性关节炎模型大鼠接受推拿治疗后软骨Toll样受体4/髓样分化因子88信号转导通路的变化[J].中国组织工程研究,2019,23(19):3019-3024. 7. Wu, Xiaoxuan, et al. "A wearable, self-adhesive, long-lastingly moist and healable epidermal sensor assembled from conductive MXene nanocomposites." Journal of Materials Chemistry C 8.5 (2020): 1788-1795.https://doi.org/10.1039/C9TC05575D 8. Jin, Yanhong, et al. "Ebselen reversibly inhibits human glutamate dehydrogenase at the catalytic site." Assay and drug development technologies 16.2 (2018): 115-122.https://doi.org/10.1089/adt.2017.822 9. Meng Wang, Min Peng, Jiang Zhu, Yi-Dong Li, Jian-Bing Zeng, Mussel-inspired chitosan modified superhydrophilic and underwater superoleophobic cotton fabric for efficient oil/water separation, Carbohydrate Polymers, Volume 244, 2020, 116449, ISSN 0144-8617, 10. Zang, Yichao, et al. "Development of a thin-layer chromatography bioautographic assay for neuraminidase inhibitors hyphenated with electrostatic field induced spray ionisation-mass spectrometry for identification of active Isatis indigotica root compounds. 11. [IF=1.62] Xiao-Hui Kuang et al."Surface functionalization of polyamide fiber via dopamine polymerization."Mater Res Express. 2017 Sep;4(9):095302 12. [IF=9.381] Meng Wang et al."Mussel-inspired chitosan modified superhydrophilic and underwater superoleophobic cotton fabric for efficient oil/water separation."Carbohyd Polym. 2020 Sep;244:116449 13. [IF=7.393] Xiaoxuan Wu et al."A wearable, self-adhesive, long-lastingly moist and healable epidermal sensor assembled from conductive MXene nanocomposites."J Mater Chem C. 2020 Feb;8(5):1788-1795 14. [IF=6.986] Xinyi Liu et al."Multifunctional Nano-Sunflowers with Color-Magnetic-Raman Properties for Multimodal Lateral Flow Immunoassay."Anal Chem. 2021;93(7):3626–3634 15. [IF=6.119] Peng Jin et al."Efficient bioconversion of high-concentration D-fructose into D-mannose by a novel N-acyl-D-glucosamine 2-epimerase from Thermobifida halotolerans."Catal Sci Technol. 2021 Mar;11(5):1922-1930 16. [IF=5.396] Hang Xu et al."The ameliorative effect of the Pyracantha fortuneana (Maxim.) H. L. Li extract on intestinal barrier dysfunction through modulating glycolipid digestion and gut microbiota in high fat diet-fed rats."Food Funct. 2019 Oct;10(10):6517-6532 17. [IF=4.759] Yichao Zang et al."Development of a thin-layer chromatography bioautographic assay for neuraminidase inhibitors hyphenated with electrostatic field induced spray ionisation-mass spectrometry for identification of active Isatis indigotica root compounds."J 18. [IF=6.475] Tao-Tao Xue et al."Evaluation of antioxidant, enzyme inhibition, nitric oxide production inhibitory activities and chemical profiles of the active extracts from the medicinal and edible plant: Althaea officinalis."Food Res Int. 2022 Jun;156:111166 19. [IF=4.539] Hao Chen et al."Ultralow friction polymer composites containing highly dispersed and thermally robust microcapsules."Colloid Surface A. 2022 Feb;634:127989 20. [IF=5.833] Song Yongxin et al."Photothermal-enhanced peroxidase-like activity of CDs/PBNPs for the detection of Fe3+ and cholesterol in serum samples."Microchim Acta. 2022 Jan;189(1):1-14 |
Tris-HCl被用于不同pH条件下的蛋白质晶体生长。Tris-HCL缓冲液的低离子强度特点可用于线虫(C. elegans)核纤层蛋白(lamin)的中间纤维的形成。Tris-HCl也是蛋白质电泳缓冲液的主要成分之一。此外,Tris-HCL还是制备表面活性剂、硫化促进剂和一些药物的中间物。Tris-HCl也被用作滴定标准物。
以三羟甲基氨基甲烷盐酸盐为溶质,以去离子水为溶剂,利用浓度为0.1mol/L 的HCl水溶液调节pH值制备浓度为6.057g/L、pH=8.8的三羟甲基氨基甲烷盐酸盐缓冲溶液(Tris-HCl缓冲液)。
白色结晶体。
所有缓冲液的pH值依赖于温度和浓度。对于Tris 缓冲液,温度每增加1°C pH增加大约 0.03 单位, 每10倍的稀释pH减少0.03-0.05 单位。
用于生物缓冲液
用作有机合成中间体
微信搜索化工百科或扫描下方二维码,添加化工百科小程序,随时随地查信息!