克立咪唑盐酸
盐酸氯咪唑(clemizole hydrochloride)
CAS: 1163-36-6
化学式: C19H21Cl2N3
| 中文名 | 盐酸氯咪唑 |
| 英文名 | clemizole hydrochloride |
| 别名 | 盐酸氯咪唑 盐酸克立咪唑 克立咪唑盐酸 克立咪唑盐酸盐 1-对氯苄基-2-(1-吡咯烷基)甲基苯并咪唑 盐酸盐 1-[(4-氯苯基)甲基]-2-(吡咯烷-1-基甲基)苯并咪唑盐酸盐 |
| 英文别名 | p48 CS-1763 allercur allercurehydrochloride clemizole hydrochloride Clemizole hydrochloride 1-P-CHLOROBENZYL-2-[1-PYRROLIDINYL]-METHYLBENZIMIDAZOLE HYDROCHLORIDE 1-{[1-(4-chlorobenzyl)-1H-benzimidazol-2-yl]methyl}pyrrolidinium chloride 1-[(4-chlorophenyl)methyl]-2-(pyrrolidin-1-ylmethyl)benzimidazole,hydrochloride 1-[(4-Chlorophenyl)methyl]-2-(pyrrolidin-1-ylmethyl)benzoimidazole hydrochloride 1-[(4-Chlorophenyl)methyl]-2-(1-pyrrolidinylmethyl)-1H-benzimidazole hydrochloride 1-[4-Chlorophenyl)methyl]-2-(1-pyrrolidinylmethyl)-1H-benzimidazole, Monohydrochloride |
| CAS | 1163-36-6 |
| EINECS | 214-605-4 |
| 化学式 | C19H21Cl2N3 |
| 分子量 | 362.3 |
| InChI | InChI=1/C19H20ClN3.ClH/c20-16-9-7-15(8-10-16)13-23-18-6-2-1-5-17(18)21-19(23)14-22-11-3-4-12-22;/h1-2,5-10H,3-4,11-14H2;1H |
| InChIKey | DNFMJYXRIMLMBZ-UHFFFAOYSA-N |
| 熔点 | 239-241° |
| 沸点 | 506.1°C at 760 mmHg |
| 闪点 | 259.9°C |
| 蒸汽压 | 2.29E-10mmHg at 25°C |
| 溶解度 | H2O: 可溶物2mg/mL，澄清 (温热) |
| 存储条件 | Inert atmosphere,2-8°C |
| 外观 | 粉末 |
| 颜色 | white to beige |
| Merck | 14,2346 |
| 体外研究 | Clemizole hydrochloride is found to inhibit HCV RNA replication in cell culture that is mediated by its suppression of NS4B’s RNA binding, with little toxicity for the host cell. The EC 50 of Clemizole on the W55R mutant J6/JFH RNA is ~18 µM (2.25 times the EC 50 of the wild-type RNA). Clemizole is a novel inhibitor of TRPC5 channels. Clemizole efficiently blocks TRPC5 currents and Ca 2+ entry in the low micromolar range (IC 50 =1.0-1.3 µM). Clemizole exhibits a six-fold selectivity for TRPC5 over TRPC4β (IC 50 =6.4 µM), the closest structural relative of TRPC5, and an almost 10-fold selectivity over TRPC3 (IC 50 =9.1 µM) and TRPC6 (IC 50 =11.3 µM). Clemizole hydrochloride as a novel blocker of TRPC5 with a half-maximal inhibitory concentration of 1.1 µM. The concentration-response curves confirmed a concentration-dependent block of TRPC5 by Clemizole and revealed an apparent IC 50 of 1.1±0.04 µM. |
| 体内研究 | Clemizole hydrochloride has an unexpectedly short plasma half-life (measured at 0.15 hours); it is very rapidly biotransformed into a glucuronide (M14) and a dealkylated metabolite (M12) and into a variety of lesser metabolites in C57BL/6J mice. |
| 危险品标志 | Xn - 有害物品 |
| 风险术语 | 22 - 吞食有害。 |
| 安全术语 | 36 - 穿戴适当的防护服。 |
| WGK Germany | 3 |
| RTECS | DD6730000 |
| 上游原料 | 氯乙酰氯 氯化钠 |
克立咪唑盐酸 - 配置溶液浓度参考
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.76 ml | 13.801 ml | 27.602 ml |
| 5 mM | 0.552 ml | 2.76 ml | 5.52 ml |
| 10 mM | 0.276 ml | 1.38 ml | 2.76 ml |
| 5 mM | 0.055 ml | 0.276 ml | 0.552 ml |
最后更新：2024-01-02 23:10:35
供应商列表
现货供应
产品名: Clemizole hydrochloride 去供应商网站查看 询盘CAS: 1163-36-6
产地: 北京
包装: 盒
规格: IC7460-5mg,5mg
价格: 电话、微信、QQ、邮件
库存: 现询
电话: 010-50973130
手机: 17801761073(微信同号)
电子邮件: 3193328036@qq.com
QQ: 3193328036
微信: 17801761073
产品描述: 索莱宝直销，欢迎来询
现货供应
产品名: Clemizole hydrochloride 去供应商网站查看 询盘CAS: 1163-36-6
产地: 上海
规格: 99%
价格: 2mg 248,5mg 360,10mg 472,25mg 800,50mg 1560,100mg 3040,200mg 4480
库存: 现货
电话: 18301782025
手机: 18301782025
电子邮件: 3008007403@qq.com
QQ: 3008007403
微信: 18301782025
产品描述: Clemizole hydrochloride 99% MedMol 货号：S82157
现货供应
产品名: Clemizole hydrochloride 去供应商网站查看 询盘CAS: 1163-36-6
产地: 北京
包装: 盒
规格: IC7460-5mg,5mg
价格: 电话、微信、QQ、邮件
库存: 现询
电话: 010-50973130
手机: 17801761073(微信同号)
电子邮件: 3193328036@qq.com
QQ: 3193328036
微信: 17801761073
产品描述: 索莱宝直销，欢迎来询
现货供应
产品名: Clemizole hydrochloride 去供应商网站查看 询盘CAS: 1163-36-6
产地: 上海
规格: 99%
价格: 2mg 248,5mg 360,10mg 472,25mg 800,50mg 1560,100mg 3040,200mg 4480
库存: 现货
电话: 18301782025
手机: 18301782025
电子邮件: 3008007403@qq.com
QQ: 3008007403
微信: 18301782025
产品描述: Clemizole hydrochloride 99% MedMol 货号：S82157
克立咪唑盐酸的上游原料
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