化合物 T10764_化工百科

中文名	尾孢素酰胺
英文名	Cercosporamide
别名	尾孢素酰胺化合物 T10764
英文别名	Cercosporamide (-)-CERCOSPORAMIDE 4-Dibenzofurancarboxamide Cercosporamide((-)-Cercosporamide) Cercosporamide from Cercosporidium henningsii (R)-8-Acetyl-9,9a-dihydro-1,3,7-trihydroxy-9aβ-methyl-9-oxodibenzofuran-4-carboxamide (9aS)-8-Acetyl-9,9a-dihydro-1,3,7-trihydroxy-9a-methyl-9-oxo-4-dibenzofurancaboxamide 4-Dibenzofurancarboxamide, 8-acetyl-9,9a-dihydro-1,3,7-trihydroxy-9a-methyl-9-oxo-, (9aS)-
CAS	131436-22-1
化学式	C16H13NO7
分子量	331.28
溶解度	氯仿: 可溶性1mg/mL
存储条件	-20°C
体外研究	Cercosporamide is a broad-spectrum natural antifungal compound, is actually a selective and highly potent fungal Pkc1 kinase inhibitor. Cercosporamide, an antifungal agent that is recently shown to act as a unique Mnk inhibitor, exhibits antileukemic properties. Cercosporamide is a potent inhibitor of phosphorylation of eIF4E at Ser209 in AML cells and results in potent inhibitory effects on primitive leukemic progenitors (CFU-L) from AML patients. To determine whether Cercosporamide exhibits negative regulatory effects on cell proliferation and viability of leukemia cells, MTT assays are conducted. When U937 cells are incubated in the presence or absence of the increasing doses of Cercosporamide, a dose-dependent suppression of cell growth is found. Similar experiments with comparable results are seen when the effects of Cercosporamide on MM6 and K562 cells are examined.
体内研究	Treatment with Cercosporamide or Ara-C alone significantly suppresses xenograft growth when compared with the respective vehicle (P<0.011 for 10 mg/kg twice-daily Cercosporamide; P<0.006 for Cercosporamide 20 mg/kg daily; P<0.0374 for Ara-C). The combination of Cercosporamide 10 mg/kg twice daily plus Ara-C is significantly more effective than either agent alone (P<0.0009 vs Cercosporamide; P=0.005 vs Ara-C; P<0.0001 vs either vehicle). Cercosporamide (20 mg/kg once daily) in combination with Ara-C shows similar effects, with significant inhibition of tumor growth vs captisol (P<0.0001) or water (P=0.0003), but does not show statistical significance vs Cercosporamide alone (20 mg/kg) or Ara-C alone.
危险品标志	Xn - 有害物品
风险术语	22 - 吞食有害。
WGK Germany	3

化合物 T10764 - 简介

尾孢素酰胺是一种有机化合物，属于尾孢素类抗生素的衍生物。以下是关于尾孢素酰胺的性质、用途、制法和安全信息的介绍：

性质：
- 尾孢素酰胺是无色结晶性固体，具有良好的溶解性。
- 它在中性和酸性条件下稳定。

用途：
- 尾孢素酰胺具有广谱抗菌活性，特别对于革兰氏阳性和阴性细菌有效。它可用于治疗多种感染性疾病，包括皮肤感染、呼吸道感染、泌尿道感染等。
- 尾孢素酰胺也可用于兽医领域，治疗动物感染疾病。

制法：
- 尾孢素酰胺的制备通常通过化学合成的方法进行，包括酰化反应和进一步的反应步骤。

安全信息：
- 使用和处理尾孢素酰胺时，必须遵守相关的安全操作规程，包括佩戴适当的防护设备，如防护眼镜、手套和实验服。
- 尾孢素酰胺是一种抗生素，应小心处理以避免其过量暴露和误用。
- 在使用尾孢素酰胺时，请遵循适当的浓度和使用方法，以确保安全有效。

最后更新：2024-04-09 19:05:17

上海麦克林生化科技股份有限公司

现货供应

产品名: Cercosporamide 去供应商网站查看询盘
CAS: 131436-22-1
产地: 上海
规格: C883280
价格: 1mg-3838,500μg-1920
库存: 15天内发货
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