化合物 T11721L_化工百科

中文名	JDTic (dihydrochloride)
英文名	JDTic (dihydrochloride)
别名	化合物 T11721L (3R)-1,2,3,4-四氢-7-羟基-N-[(1S)-1-[[(3R,4R)-4-(3-羟基苯基)-3,4-二甲基-1-哌啶基]甲基]-2-甲基丙基]-3-异喹啉甲酰胺盐酸盐
英文别名	CS-648 JDTic (2HCl) JDTic (dihydrochloride) (R)-7-hydroxy-N-((S)-1-((3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl)-3-methylbutan-2-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide (3R)-7-hydroxy-N-[(1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide (R)-7-hydroxy-N-((S)-1-((3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl)-3-methylbutan-2-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide dihydrochloride (3R)-7-hydroxy-N-[(2S)-1-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]-3-methylbutan-2-yl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide dihydrochloride (3R)-1,2,3,4-Tetrahydro-7-hydroxy-N-[(1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-2-methylpropyl]-3-isoquinolinecarboxamide hydrochloride
CAS	785835-79-2
化学式	C28H40ClN3O3
分子量	502.0885
溶解度	10毫米DMSO
存储条件	-20℃
体内研究	JDTic (2.5-16 mg/kg, s.c.) dose-dependently blocks the antinociceptive response of nicotine in the tail-flick test but has no effect in the hot-plate assay or body temperature assessments at any dose tested in the mice injected with nicotine. JDTic (3 mg/kg, i.p.) is capable of reversing anxiety-like behavior in the rat model of hangover anxiety. JDTic (10 mg/kg, i.p.) decreases alcohol self-administration, suppresses cue-induced reinstatement of alcohol seeking, and specifically blocks the effects of a KOR agonist at the 2 h pretreatment time point. JDTic (30 mg/kg, i.g.) significantly blockes U50,488-induced diuresis immediately in rats.

化合物 T11721L - 配置溶液浓度参考

	1mg	5mg	10mg
1 mM	1.857 ml	9.284 ml	18.568 ml
5 mM	0.371 ml	1.857 ml	3.714 ml
10 mM	0.186 ml	0.928 ml	1.857 ml
5 mM	0.037 ml	0.186 ml	0.371 ml

最后更新：2024-01-02 23:10:35

上海吉至生化科技有限公司

现货供应

产品名: JDTic (dihydrochloride) 去供应商网站查看询盘
CAS: 785835-79-2
产地: 中国上海
包装: 50mg
规格: 99%
价格: 8694.00
库存: 现货
电话: 400-900-4166
手机: 18017137653
电子邮件: 3007523013@qq.com
QQ: 3007523013

微信: 18017137653
产品描述: 中文名：JDTic (dihydrochloride) 英文名:JDTic dihydrochloride CAS:785835-79-2 规格:99% 产地: 更多

上海麦克林生化科技股份有限公司

现货供应

产品名: JDTic dihydrochloride 去供应商网站查看询盘
CAS: 785835-79-2
产地: 上海
规格: J877374
价格: 5mg-1547,10mg-2431
库存: 7天内发货
电话: 13816333479/13918391375
手机: 13816333479/13918391375
电子邮件: wangrui@macklin.cn
QQ: 2885703204/285395191

微信: 19863730987/13918391375

上海源叶生物科技有限公司

产品名: JDTic (dihydrochloride) 去供应商网站查看询盘
CAS: 785835-79-2
产地: 上海
规格: 98%
价格: 5mg 1400,10mg 2200
电话: 18301782025
手机: 18301782025
电子邮件: 3008007403@qq.com
QQ: 3008007403