化合物 T12169_化工百科

中文名	NALTRINDOLE HYDROCHLORIDE
英文名	NALTRINDOLE HYDROCHLORIDE
别名	纳曲吲哚盐酸盐化合物 T12169
英文别名	NTI NaltrindoleHCl NTI HYDROCHLORIDE NALTRIDOLE HYDROCHLORIDE NALTRINDOLE HYDROCHLORIDE NALTRINDOLE HYDROCHLORIDE (NTI) NON-PEPT IDE DELTA OPI 17-(CYCLOPROPYLMETHYL)-6,7-DEHYDRO-4,5A-EPOXY-3,14-DIHYDROXY-6,7-2',3'-INDOLOMORPHINAN HYDROCHLORIDE 17-(Cyclopropylmethyl)-6,7-dehydro-4,5alpha-epoxy-3,14-dihydroxy-6,7-2',3'-indolomorphinan hydrochloride
CAS	111469-81-9
化学式	C26H27ClN2O3
分子量	450.96
溶解度	甲醇: 4.5mg/ml
存储条件	−20°C
外观	固体
颜色	off-white
体外研究	Opioid drugs exert a wide spectrum of physiological and behavioral effects. These effects are mediated via membrane-bound receptors, of which the best characterized are the kappa, delta, and mu receptors. Naltrindole inhibits the proliferation of cultured human U266 MM cells in a time- and dose-dependent manner with an EC 50 of 16 μM. Treatment of U266 cells with naltrindole significantly decreases the level of the active, phosphorylated form of the kinases, extracellular signal-regulated kinase and Akt, which may be related to its antiproliferative activity. Naltrindole inhibits growth and induces apoptosis in the three characteristic SCLC cell lines, NCI-H69, NCI-H345, and NCI-H510. Naltrindole treatment reduces constitutive phosphorylation of Akt/PKB on serine 473 and threonine 308 in cells and also its downstream effectors glycogen synthase kinase-3β and the Forkhead transcription factors AFX and FKHR.
体内研究	Naltrindole significantly decreases tumor cell volumes in human MM cell xenografts in severe combined immunodeficient mice. In mice, naltrindole at 20 mg/kg s.c. antagonizes the δ-selective agonist effect of [D- Ser, Leu, Thr]enkephalin (DSLET) without blocking the antinociceptive effect of morphine or U50488H. Naltrindole is the only highly selective δ antagonist that is active upon peripheral administration. Acute naltrindole induces significant decreases in external and total ambulation (horizontal activity) and rearing behaviour (vertical activity), as well as a significant increase in grooming frequency. In animals chronically treated with naltrindole there is an increase in total ambulation one day after the discontinuation of the treatment.
WGK Germany	3
上游原料	盐酸苯肼

化合物 T12169 - 配置溶液浓度参考

	1mg	5mg	10mg
1 mM	2.218 ml	11.088 ml	22.175 ml
5 mM	0.444 ml	2.218 ml	4.435 ml
10 mM	0.222 ml	1.109 ml	2.218 ml
5 mM	0.044 ml	0.222 ml	0.444 ml

最后更新：2024-01-02 23:10:35

上海吉至生化科技有限公司

现货供应

产品名: Naltrindole hydrochloride 去供应商网站查看询盘
CAS: 111469-81-9
产地: 中国上海
包装: 10mg
规格: 99%
价格: 2778.00
库存: 现货
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产品描述: 中文名：Naltrindole hydrochloride 英文名:NALTRINDOLE HYDROCHLORIDE CAS:111469-81-9 规格:9 更多

上海麦克林生化科技股份有限公司

现货供应

产品名: Naltrindole hydrochloride 去供应商网站查看询盘
CAS: 111469-81-9
产地: 上海
规格: N766608
价格: 50mg-9150,10mg-3050,5mg-1785
库存: 现货
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上海源叶生物科技有限公司

产品名: NALTRINDOLE HYDROCHLORIDE 去供应商网站查看询盘
CAS: 111469-81-9
产地: 上海
规格: 99%
价格: 5mg 990,10mg 1350,25mg 2950,50mg 5300
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