化合物AMITIFADINE HYDROCHLORIDE

中文名	Amitifadine (hydrochloride)
英文名	Amitifadine (hydrochloride)
别名	化合物AMITIFADINE HYDROCHLORIDE
英文别名	EB-1010 HYDROCHLORIDE DOV-21947 HYDROCHLORIDE DOV 21947 hydrochloride EB 1010 (Hydrochloride) AMitifadine hydrochloride Amitifadine (hydrochloride) DOV 21947 hydrochloride(Amitifadine hydrochloride) (1R,5S)-1-(3,4-DICHLOROPHENYL)-3-AZABICYCLO[3.1.0]HEXANE HYDROCHLORIDE
CAS	410074-74-7
化学式	C11H12Cl3N
分子量	264.57868
溶解度	10毫米DMSO
存储条件	-20℃
体外研究	Amitifadine (DOV 21,947) is an antidepressant drug. K i values for SERT, NET, and DAT are 99 nM, 262 nM, and 213 nM. The IC 50 values for serotonin, norepinephrine and dopamine uptake are 12, 23 and 96 nM, respectively.
体内研究	The 30 mg/kg Amitifadine dose significantly reduces nicotine self-administration. The 5 and 10 mg/kg doses reduce nicotine self-administration during the first 15 min. of the session when the greatest amount of nicotine is self-administered. The 30 mg/kg Amitifadine dose, but not the lower doses cause a significant reduction in locomotor activity averaged over the 1-hour session and reduce food motivated responding. The 10 mg/kg dose causes hypoactivity at the beginning of the session, but 5 mg/kg does not cause any hypoactivity. The effect of chronic Amitifadine treatment (10 mg/kg) over the course of 15 sessions is also determined. Amitifadine causes a significant reduction in nicotine self-administration, which is not seen to diminish over two consecutive weeks of treatment and a week after enforced abstinence. Amitifadine significantly reduces nicotine self-administration. This prompts further research to determine if Amitifadine might be an effective treatment for smoking cessation.

化合物AMITIFADINE HYDROCHLORIDE - 配置溶液浓度参考

	1mg	5mg	10mg
1 mM	3.78 ml	18.898 ml	37.796 ml
5 mM	0.756 ml	3.78 ml	7.559 ml
10 mM	0.378 ml	1.89 ml	3.78 ml
5 mM	0.076 ml	0.378 ml	0.756 ml

最后更新：2024-01-02 23:10:35

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产品名: Amitifadine (hydrochloride) 去供应商网站查看询盘
CAS: 410074-74-7
产地: 中国上海
包装: 10mg
规格: 99%
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产品名: Amitifadine hydrochloride 去供应商网站查看询盘
CAS: 410074-74-7
产地: 上海
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产品名: Amitifadine (hydrochloride) 去供应商网站查看询盘
CAS: 410074-74-7
产地: 上海
规格: 98%
价格: 5mg 3500,10mg 6000
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