化合物KB-R7943_化工百科

中文名	KB-R7943甲磺酰酸盐
英文名	2-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE
别名	化合物KB-R7943 KB-R7943 甲磺酸盐 KB-R7943甲磺酰酸盐 KB-R7943 甲磺酰酸盐 4-[(4-硝基苄基)氧代]苯基乙基]异硫脲甲磺酸盐 S-[4-[(4-硝基苄基)氧代]苯乙基]异硫脲甲磺酸盐 S-[4-[(4-NITROBENZYL)OXY]PHENETHYL]ISOTHIOUREA METHANESULFONATE S-[4-[(4-硝基苄基)氧代]苯乙基]异硫脲甲磺酸盐
英文别名	KB-R7943 KB-R7943 MESYLATE 2-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE S-[4-[(4-Nitrobenzyl)oxy]phenethyl]isothiourea Methanesulfonate 4-((4-Nitrobenzyl)oxy)phenethyl carbaMiMidothioate Methanesulfonate 2-(2-(4-(4-NITROBENZYLOXY)PHENYL)ETHYL)ISOTHIOUREA, METHANE SULFONATE Carbamimidothioic acid 2-[4-[(4-nitrophenyl)methoxy]phenyl]ethyl ester methanesulfonate Carbamimidothioic acid 2-[4-[(4-nitrophenyl)methoxy]phenyl]ethyl ester monomethanesulfonate
CAS	182004-65-5
化学式	C17H21N3O6S2
分子量	427.5
InChI	InChI=1/C16H17N3O3S.CH4O3S/c17-16(18)23-10-9-12-3-7-15(8-4-12)22-11-13-1-5-14(6-2-13)19(20)21;1-5(2,3)4/h1-8H,9-11H2,(H3,17,18);1H3,(H,2,3,4)
熔点	>214°C (dec.)
沸点	534.6°C at 760 mmHg
闪点	277.1°C
蒸汽压	1.67E-11mmHg at 25°C
溶解度	溶于DMSO (高达50 mg/ml)。
存储条件	Inert atmosphere,2-8°C
稳定性	从提供的购买之日起稳定2年。DMSO中的溶液可以在-20 °C下储存长达3个月。
外观	白色结晶固体
颜色	Tan
体外研究	KB-R7943 mesylate blocks NMDAR-mediated ion currents, and inhibits NMDA-induced increase in cytosolic Ca 2+ with IC 50 =13.4±3.6 µM but accelerates calcium deregulation and mitochondrial depolarization in glutamate-treated neurons. KB-R7943 depolarizes mitochondria in a Ca 2+ -independent manner. KB-R7943 inhibits 2,4-dinitrophenol-stimulated respiration of cultured neurons with IC 50 =11.4±2.4 µM. In addition to NCX rev , KB-R7943 dose-dependently and reversibly blocked ion currents elicited by NMDA. KB-R7943 dose-dependently inhibits NMDA-induced increases in [Ca 2+ ] c with IC 50 =13.4±3.6 µM confirming the inhibition of NMDA receptors observed in electrophysiological experiments. wt RyR1-HEK 293 pretreated with KB-R7943 (10 μM, 10 min) dissolved in the bulk perfusion exhibited significantly attenuated responses to caffeine. In this regard, KB-R7943 produced more pronounced inhibition of caffeine-induced Ca 2+ release elicited by 1 mM compared with 0.5 and 0.75 mM (60 versus 58 versus 37%, p<0.05, respectively). KB-R7943 inhibits both I hERG and native I Kr rapidly on membrane depolarization with IC 50 values of ~89 and ~120 nM, respectively, for current tails at −40 mV following depolarizing voltage commands to +20 mV. I hERG inhibition by KB-R7943 exhibits both time- and voltage-dependence but shows no preference for inactivated over activated channels.

化合物KB-R7943 - 配置溶液浓度参考

	1mg	5mg	10mg
1 mM	2.339 ml	11.696 ml	23.392 ml
5 mM	0.468 ml	2.339 ml	4.678 ml
10 mM	0.234 ml	1.17 ml	2.339 ml
5 mM	0.047 ml	0.234 ml	0.468 ml

最后更新：2024-01-02 23:10:35

上海麦克林生化科技股份有限公司

主打产品现货供应

产品名: S-[4-[(4-硝基苄基)氧代]苯乙基]异硫脲甲磺酸盐去供应商网站查看询盘
CAS: 182004-65-5
产地: 上海
规格: S868364
价格: 10mg-634,50mg-1228,100mg-1872,250mg-2809,1ml-467
库存: 现货
电话: 13816333479/17821173903
手机: 13816333479/17821173903
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北京索莱宝科技有限公司

提供多种规格现货供应

产品名: KB-R7943甲磺酰酸盐去供应商网站查看询盘
CAS: 182004-65-5
产地: 北京
包装: 瓶
规格: YS148278-50mg
价格: 电话、微信、QQ、邮件
库存: 一周左右
电话: 010-50973130
手机: 17801761073(微信同号)
电子邮件: 3193328036@qq.com
QQ: 3193328036

微信: 17801761073
产品描述: 索莱宝直销，欢迎来询

上海吉至生化科技有限公司

现货供应

产品名: KB-R7943甲磺酰酸盐去供应商网站查看询盘
CAS: 182004-65-5
产地: 中国上海
包装: 50mg
规格: 95%
价格: 270.00
库存: 10个工作日
电话: 400-900-4166
手机: 18017137653
电子邮件: 3007523013@qq.com
QQ: 3007523013

微信: 18017137653
产品描述: 中文名：KB-R7943甲磺酰酸盐英文名:2-[2-[4-(4-Nitrobenzyloxy)Phenyl]Ethyl]Isothiourea Mesylat 更多

上海源叶生物科技有限公司

现货供应

产品名: KB-R7943 mesylate 去供应商网站查看询盘
CAS: 182004-65-5
产地: 上海
规格: 98%
价格: 5mg 320,10mg 480,50mg 1400
库存: 现货
电话: 18301782025
手机: 18301782025
电子邮件: 3008007403@qq.com
QQ: 3008007403