中文名 | KDU691 |
英文名 | KDU691 |
别名 | 化合物KDU691 |
英文别名 | KDU691 KDU-691 KDU 691 1513879-19-0 Imidazo[1,2-a]pyrazine-6-carboxamide, N-(4-chlorophenyl)-N-methyl-3-[4-[(methylamino)carbonyl]phenyl]- |
CAS | 1513879-19-0 |
化学式 | C22H18ClN5O2 |
分子量 | 419.86 |
密度 | 1.35±0.1 g/cm3(Predicted) |
酸度系数 | 14.59±0.46(Predicted) |
存储条件 | -20℃ |
体内研究 | During the 5 days of dosing, no major weight changes are observed in the animals that receive KDU691 as prophylactic treatment (group 691-proph). From the fourth day of dosing, the animals that are treated with KDU691 show a transient yellow skin color. The KDU691 radical-cure group (group 691-RC) becomes blood-stage positive again at 31.8 days p.i. (range, 31 to 32 days). Clinical chemistry analysis of the group 691-RC monkeys reveals that bilirubin levels accumulate during the 5-day radical-cure treatment with KDU691. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.382 ml | 11.909 ml | 23.817 ml |
5 mM | 0.476 ml | 2.382 ml | 4.763 ml |
10 mM | 0.238 ml | 1.191 ml | 2.382 ml |
5 mM | 0.048 ml | 0.238 ml | 0.476 ml |
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