中文名 | NSC 95397 |
英文名 | NSC 95397 |
别名 | 化合物NSC 95397 2,3-双(2-羟基乙硫基)-1,4-萘二酮 |
英文别名 | NSC 95397 Cdc25 Inhibitor IV, NSC 95397 2,3-BIS[(2-HYDROXYETHYL)THIO]-1,4-NAPHTHOQUINONE 2,3-BIS(2-HYDROXYETHYLTHIO)-1,4-NAPHTHALENEDIONE 2,3-BIS[(2-HYDROXYETHYL)THIOL]-1,4-NAPHTHOQUINONE 1,4-Naphthalenedione, 2,3-bis[(2-hydroxyethyl)thio]- |
CAS | 93718-83-3 |
化学式 | C14H14O4S2 |
分子量 | 310.39 |
溶解度 | DMSO: 16 mg/mL |
存储条件 | -20°C |
稳定性 | 从提供的购买之日起稳定1年。DMSO或乙醇中的溶液可以在-20 °C下储存长达1个月。 |
外观 | 橙色固体 |
颜色 | orange, solid |
MDL号 | MFCD04040032 |
体外研究 | NSC 95397 (0, 10, and 20 µM; 24 hour) decreases the cell viability of three colon cancer cell lines SW480, SW620, and DLD-1 in a concentration-dependent manner. NSC 95397(10 μM; 24 hour) upregulates p21 while downregulates CDK4 and CDK6 were d in all three colon cancer cell lines SW480, SW620, and DLD-1 cells. NSC 95397 (10 μM; 24 hour) reduces the phosphorylation of retinoblastoma protein (Rb) on Ser795 and Ser807/811. NSC 95397 (20 μM; 24 hours) significantly increases cleaved caspase-9, -3, -7 and PARP levels. NSC 95397 (10 μM; 6 hours) enhances the phosphorylation of its downstream ERK1/2 at Thr202/Tyr 204. Cell Viability Assay Cell Line: Human colon cancer cell lines, SW480, SW620, and DLD-1 Concentration: 0, 10, and 20 µM Incubation Time: 24 hours Result: The IC 50 values of NSC 95397 for the cell growth of SW480, SW620, and DLD-1 cells were 9.9, 14.1 and 18.6 μM, respectively. Western Blot Analysis Cell Line: SW480, SW620, and DLD-1 cells Concentration: 10 μM Incubation Time: 24 hours Result: p21 was upregulated while CDK4 and CDK6 were downregulated. Rduced the phosphorylation of Rb on Ser795 and Ser807/811 |
危险品标志 | Xi - 刺激性物品 |
WGK Germany | 3 |
Hazard Class | IRRITANT |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 3.222 ml | 16.109 ml | 32.218 ml |
5 mM | 0.644 ml | 3.222 ml | 6.444 ml |
10 mM | 0.322 ml | 1.611 ml | 3.222 ml |
5 mM | 0.064 ml | 0.322 ml | 0.644 ml |
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