大戟二烯醇
大戟二烯醇(Euphol)
CAS: 514-47-6
化学式: C30H50O
| 中文名 | 大戟二烯醇 |
| 英文名 | Euphol |
| 别名 | 大戟甾醇 大戟二烯醇 大戟二烯醇对照品 |
| 英文别名 | Euphol euphol Euphadienol alpha-Eupho Euphol, Euphadienol 5.α.-Eupha-8,24-dien-3.β.-ol (13α,14β,17α)-5α-Lanosta-8,24-dien-3β-ol Lanosta-8,24-dien-3-ol,(3b,13a,14b,17a)- Lanosta-8,24-dien-3-ol, (3β,13α,14β,17α)- |
| CAS | 514-47-6 |
| 化学式 | C30H50O |
| 分子量 | 426.72 |
| 密度 | 0.98±0.1 g/cm3 (20 ºC 760 Torr) |
| 熔点 | 116-117℃ |
| 沸点 | 498.9±44.0 °C(Predicted) |
| 比旋光度 | (CHCl3)+32 |
| 溶解度 | 易溶于正己烷、三氯甲烷、甲醇 |
| 酸度系数 | 15.16±0.70(Predicted) |
| 存储条件 | 2-8℃ |
| 外观 | 白色粉末 |
| 物化性质 | 白色粉末，易溶于正己烷、三氯甲烷、甲醇，来源于甘遂，京大戟。 |
| MDL号 | MFCD01716323 |
| 体外研究 | Euphol (0.01-0.3 mM; 24-72 hours) markedly inhibits T47D cells proliferation, the IC 50 values of euphol treatment for 24, 48 and 72 h were 0.26, 0.22 and 0.13 mM, respectively. Euphol (0.03 mM; 48 or 72 hours) leads to cell cycle arrest by regulating expression of cell cycle-associated proteins. Cell Proliferation Assay Cell Line: T47D cells Concentration: 0.01, 0.03, 0.1 and 0.3 mM Incubation Time: 24, 48 and 72 hours Result: Decreased the percentage of viable cells. Western Blot Analysis Cell Line: T47D cells Concentration: 0.03 mM Incubation Time: 48 and 72 hours Result: Increased the expression of p21 and p27, reduced the expression of cyclin A, B1 and D. |
| 参考资料 展开查看 | 1. [IF=5.11] Weibo Qiao et al."De Novo Biosynthesis of the Anticancer Compound Euphol in Saccharomyces cerevisiae."Acs Synth Biol. 2021;10(9):2351–2358 2. [IF=3.935] Wenting Zhang et al."Screening and identification of Euphorbiae pekinensis Rupr. anti-angiogenic multi-components with UPLC-QTOF-MS in zebrafish."J Pharmaceut Biomed. 2022 Jan;207:114396 |
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