中文名 | 4,7-二羟基异黄酮 |
英文名 | Daidzein |
别名 | 大豆素 大豆苷元 大豆黄酮 黄豆苷原 大豆甙元 黄豆苷元 大豆提取物 4,7-二羟基异黄酮 4',7-二羟基异黄酮 4',7-二羟基-异磺酮 大豆素,黄豆苷元(标准品) DAIDZEIN 大豆苷元 7,4二羟基异黄酮,黄豆苷原 |
英文别名 | Daidsein DAIDZEIN Daidzein 4,7-Dihydroxyisoflavone 4',7-Dihydroxyisoflavone 4',7-dihydroxy-isoflavon 4,7-Dihydroxyisoflavone(Daidzein) DAIDZEIN, (AMERICAN HERBAL PHARMACOPOEIA) 5-hydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one 7-hydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one |
CAS | 486-66-8 |
EINECS | 207-635-4 |
化学式 | C15H10O4 |
分子量 | 254.24 |
InChI | InChI=1/C15H10O4/c16-10-6-4-9(5-7-10)11-8-19-13-3-1-2-12(17)14(13)15(11)18/h1-8,16-17H |
密度 | 1.1629 (rough estimate) |
熔点 | 315-323°C (dec.) |
沸点 | 317.45°C (rough estimate) |
闪点 | 190°C |
水溶性 | insoluble |
蒸汽压 | 4.53E-10mmHg at 25°C |
溶解度 | DMSO: 10 mg/mL |
折射率 | 1.4300 (estimate) |
酸度系数 | 7.01±0.20(Predicted) |
存储条件 | 2-8°C |
外观 | 粉末 |
颜色 | White to off-white |
Merck | 14,2801 |
BRN | 231523 |
物化性质 | 来源于豆科植物大豆。 |
MDL号 | MFCD00016954 |
危险品标志 | Xi - 刺激性物品 |
风险术语 | 36/38 - 刺激眼睛和皮肤。 |
安全术语 | S24 - 避免皮肤接触。 S26 - 不慎与眼睛接触后,请立即用大量清水冲洗并征求医生意见。 S37/39 - 戴适当的手套和护目镜或面具。 |
WGK Germany | 3 |
RTECS | DJ3100040 |
海关编号 | 29329990 |
Hazard Class | IRRITANT |
上游原料 | 盐酸 乙醇 乙醚 |
下游产品 | 4',6,7-三羟异黄酮 |
参考资料 展开查看 | 1. 周荧,魏建林,罗胜保,张欣,彭毛.固定化β-葡萄糖苷酶在异黄酮生物转化中的应用[J].粮食科技与经济,2016,41(02):37-40+50. 2. 刘舵, 杨永利, 雷婷,等. 枸杞子乙酸乙酯提取物急性毒性及对切除卵巢大鼠骨质疏松的防治作用[J]. 中国骨质疏松杂志, 2016, 22(04):396-401. 3. 张圳, 冯家懿, 果卉,等. 高效液相色谱法测定体外大鼠肠道菌液中大豆苷及其代谢物[J]. 药学实践杂志, 2018(4). 4. 梅余琪, 魏丽芳, 邹立思,等. 鸡血藤中多元活性成分动态积累的分析与评价[J]. 中国中药杂志, 2020, v.45(03):134-145. 5. 梅余琪, 魏丽芳, 邹立思,等. 鸡血藤韧皮部环数与多指标成分的相关性分析[J]. 分析测试学报, 2020(8):941-949. 6. 黄紫炎 沈钱能 李平 等. 不同产地葛根饮片的UPLC指纹图谱结合多成分含量测定研究[J]. 中国中药杂志 2019 v.44(10):93-100. 7. 沈发迪, 张震, 梁武,等. 工业化规模生产的含有后生素益生菌纳豆固体饮料的研究[J]. 职业与健康, 2020, v.36(05):43-47. 8. 李博,赵安琦,张慧荣,李丽.应用超滤液相色谱和电喷雾质谱技术筛选MMP-2活性成分[J].分子科学学报,2015,31(02):94-100. 9. 李圆圆, 田晨颖, 刘晓美,等. 添加微量元素对黑豆发芽过程中成分的影响[J]. 食品工业科技, 2019, 40(09):104-110. 10. 申春莉, 沙见宇, 李曼,等. 灵芝固态发酵豆渣的抗氧化特性变化研究[J]. 食品研究与开发, 2019, 040(024):60-64. 11. ]滕飞[1], 李博[1], 谢静[1],等. 葛根中抑制磷酸二酯酶4活性成分的筛选研究[J]. 分子科学学报(中,英文), 2018(1). 12. 王飞霞 杨晓华 张华峰 朱春燕 李璐 王凤忠.3种豆芽中异黄酮、多酚的体外抗氧化活性及其对果蝇SOD、GSH-Px活力的影响[J].中国食品学报 2018 18(11):57-64. 13. 刘露 马金同 沈小梅 等. 一种保健酒中5种大豆异黄酮及芝麻素的超高效液相色谱检测法[J]. 酿酒 2019 046(004):86-88. 14. 朱怡霖, 张海生, 赵鑫帅,等. 大孔树脂分离纯化横山老黑豆酚类物质[J]. 食品与生物技术学报, 2019, 038(009):103-110. 15. 吴文杰 邓阳 谭桂林 罗娟 陈秧 黄莺 张峰.一测多评法测定葛根药材中5种异黄酮类成分[J].中草药 2017 48(04):777-781. 16. 刘杰 何钢 刘贤桂 等. 人工栽培鸡血藤中五种黄酮类物质含量测定[J]. 分子植物育种 2017 015(009):3832-3837. 17. 靳羽慧, 刘长忠, 徐响,等. 蒸汽爆破对豆渣中大豆异黄酮的影响研究[J]. 中国粮油学报, 2017(10). 18. 唐君, 付强, 崔勐,等. 黄酮与溶菌酶相互作用的强度衰减-基质辅助激光解吸离子化-质谱研究[J]. 分析化学, 2016, 044(007):1071-1076. 19. 郭天赐, 赵石磊, 刘石生. 苦杏仁β-葡萄糖苷酶水解豆浆中大豆异黄酮的工艺研究[J]. 食品研究与开发, 2019(12). 20. 赵石磊, 何旭, 王爱珠,等. 酶法提高豆浆中大豆异黄酮苷元含量的工艺研究[J]. 食品工业, 2019, 040(001):100-104. 21. 周凯文, 陈晓默, 刘慧琳,等. 多酚黄酮物质对晚期糖基化终产物的抑制研究[J]. 食品研究与开发, 2018, v.39;No.329(04):7-13. 22. 陈佳丽,谈梦霞,邹立思,刘训红,陈舒妤,石婧婧,王程成,梅余琪.超快速液相色谱-三重四级杆/线性离子阱质谱法同时测定不同产地竹节参药材中多元成分[J].中国药学杂志,2019,54(03):226-233. 23. 黄玉军,周帆,于俊娟,李颖华,顾瑞霞.高转化大豆异黄酮乳酸菌的筛选及在豆乳中的发酵特性[J].食品研究与开发,2021,42(03):157-162. 24. 梅余琪,魏丽芳,邹立思,刘训红,陈佳丽,谈梦霞,王程成,蔡芷辰,殷圣鑫,张芙蓉.鸡血藤韧皮部环数与多指标成分的相关性分析[J].分析测试学报,2020,39(08):941-949. 25. 杜静,王琪琪,王云胜,张传博.冠突散囊菌发酵对葛根的活性物质和抗氧化活性的影响[J].食品工业科技,2021,42(01):121-125+131. 26. 曹冬英,李鸷,许文,隋利强,徐伟.4种市售黑豆及成品淡豆豉中异黄酮含量分析[J].药学研究,2020,39(10):581-584. 27. 许金国,黄紫炎,沈钱能,李林,王巧晗,王璐,陆兔林,毛春芹.经典名方竹茹汤的指纹图谱及功效关联物质预测分析[J].中国中药杂志,2020,45(23):5599-5606. 28. 常冠华,薄颖异,崔洁,徐露露,赵梓邯,王文全,侯俊玲.基于UPLC-Q-Exactive Orbitrap-MS分析甘草地上部分主要化学成分[J].中国中药杂志,2021,46(06):1449-1459. 29. 王晶,赵重博,唐家琪,卜雕雕,邹俊波,张小飞,程江雪,王昌利.高效液相色谱法同时测定复方龙脉宁中7种成分的含量[J].中南药学,2020,18(11):1903-1905. 30. 周文红,郭咪咪,毕艳红,王朝宇,段章群.酶解制备苷元型大豆异黄酮[J].中国油脂,2020,45(12):100-104. 31. 李承浩,王萌,任晓亮.磺化杯6芳烃对4类中药单体成分增溶作用及其机制研究[J].中国现代中药,2020,22(12):2032-2038. 32. 黄玉军,周帆,李颖华,于俊娟,顾瑞霞.植物乳杆菌58发酵豆乳产大豆异黄酮苷元条件的优化[J].现代食品科技,2021,37(02):183-190. 33. Yang, Yan-Fang, Lei Zhang, and Xiu-Wei Yang. "Distribution assessments of coumarins from Angelicae Pubescentis Radix in rat cerebrospinal fluid and brain by Liquid Chromatography Tandem Mass Spectrometry analysis." Molecules 23.1 (2018): 225.https://doi.or 34. Yiming Liang, Chen Qu, Ran Yang, Lingbo Qu, Jianjun Li, Molecularly imprinted electrochemical sensor for daidzein recognition and detection based on poly(sodium 4-styrenesulfonate) functionalized graphene, Sensors and Actuators B: Chemical, Volume 251, 201 35. Huang, Guocheng, Weixi Cai, and Baojun Xu. "Improvement in beta-carotene, vitamin B2, GABA, free amino acids and isoflavones in yellow and black soybeans upon germination." LWT 75 (2017): 488-496.https://doi.org/10.1016/j.lwt.2016.09.029 36. Zhang, Hongguang, et al. "Extraction of isoflavones from Puerariae lobata using subcritical water." RSC advances 8.40 (2018): 22652-22658.https://doi.org/10.1039/C8RA02653J 37. Zhang, Hongguang, et al. "Extraction of isoflavones from Puerariae lobata using subcritical water." RSC advances 8.40 (2018): 22652-22658.https://doi.org/10.1039/C8RA02653J 38. Huang, Xiya, Weixi Cai, and Baojun Xu. "Kinetic changes of nutrients and antioxidant capacities of germinated soybean (Glycine max L.) and mung bean (Vigna radiata L.) with germination time." Food chemistry 143 (2014): 268-276.https://doi.org/10.1016/j.foo 39. Zhu, Yi-Lin, et al. "Composition, distribution, and antioxidant activity of phenolic compounds in 18 soybean cultivars." Journal of AOAC International 101.2 (2018): 520-528.https://doi.org/10.5740/jaoacint.17-0156 40. Zhou, Jing, et al. "A strategy for rapid discovery of traceable chemical markers in herbal products using MZmine 2 data processing toolbox: A case of Jing Liqueur." Chinese Herbal Medicines (2021). 41. [IF=7.514] Xiya Huang et al."Kinetic changes of nutrients and antioxidant capacities of germinated soybean (Glycine max L.) and mung bean (Vigna radiata L.) with germination time."Food Chem. 2014 Jan;143:268 42. [IF=7.514] Lu Xu et al."A systematic, comparative study on the beneficial health components and antioxidant activities of commercially fermented soy products marketed in China."Food Chem. 2015 May;174:202 43. [IF=7.514] Liang Lv et al."Thermally-induced whey protein isolate-daidzein co-assemblies: Protein-based nanocomplexes as an inhibitor of precipitation/crystallization for hydrophobic drug."Food Chem. 2019 Mar;275:273 44. [IF=7.46] Yiming Liang et al."Molecularly imprinted electrochemical sensor for daidzein recognition and detection based on poly(sodium 4-styrenesulfonate) functionalized graphene."Sensor Actuat B-Chem. 2017 Nov;251:542 45. [IF=4.952] Guocheng Huang et al."Improvement in beta-carotene, vitamin B2, GABA, free amino acids and isoflavones in yellow and black soybeans upon germination."Lwt Food Sci Technol. 2017 Jan;75:488 46. [IF=4.411] Yan-Fang Yang et al."Distribution Assessments of Coumarins from Angelicae Pubescentis Radix in Rat Cerebrospinal Fluid and Brain by Liquid Chromatography Tandem Mass Spectrometry Analysis."Molecules. 2018 Jan;23(1):225 47. [IF=3.738] Selma Houchi et al."Investigation of common chemical components and inhibitory effect on GES-type β-lactamase (GES22) in methanolic extracts of Algerian seaweeds."Microb Pathogenesis. 2019 Jan;126:56 48. [IF=3.645] Wenjie Wu et al."Simple, rapid, and environmentally friendly method for the separation of isoflavones using ultra-high performance supercritical fluid chromatography."J Sep Sci. 2017 Jul;40(13):2827-2837 49. [IF=3.361] Hongguang Zhang et al."Extraction of isoflavones from Puerariae lobata using subcritical water."Rsc Adv. 2018 Jun;8(40):22652-22658 50. [IF=2.896] Bo Li et al."Preparative separation of isoflavones in plant extract of Pueraria lobata by high performance counter-current chromatography."Anal Methods-Uk. 2015 Feb;7(4):1321-1327 51. [IF=2.19] Y.J. Chen et al."Phytochemical Profiles of Edible Kudzu (Pueraria thomsonii Benth) Grown in China as Affected by Thermal Processing."J Food Process Pres. 2017 Feb;41(1):e12754 52. [IF=1.913] Zhu Yi-Lin et al."Composition, Distribution, and Antioxidant Activity of Phenolic Compounds in 18 Soybean Cultivars."J Aoac Int. 2018 Mar;101(2):520-528 53. [IF=7.514] Xiaoming Yu et al."Impact of processing technologies on isoflavones, phenolic acids, and antioxidant capacities of soymilk prepared from 15 soybean varieties."Food Chem. 2021 May;345:128612 54. [IF=7.491] Guoping Yu et al."Preparation of Daidzein microparticles through liquid antisolvent precipitation under ultrasonication."Ultrason Sonochem. 2021 Nov;79:105772 55. [IF=7.132] Li Yang et al."Supercritical extraction and antioxidant activity of major ingredients in Puerariae lobatae root, Pinus massoniana needle, Citrus reticulata peel and their mixture."J Co2 Util. 2021 Jun;48:101518 56. [IF=5.81] Han Lifeng et al."Rapid Discovery of the Potential Toxic Compounds in Polygonum multiflorum by UHPLC/Q-Orbitrap-MS-Based Metabolomics and Correlation Analysis."Front Pharmacol. 2019 Apr;0:329 57. [IF=5.64] Liang Wenou et al."Colonization Potential to Reconstitute a Microbe Community in Pseudo Germ-Free Mice After Fecal Microbe Transplant From Equol Producer."Front Microbiol. 2020 Jun;0:1221 58. [IF=4.879] Yang Liu et al."UV-B Radiation Largely Promoted the Transformation of Primary Metabolites to Phenols in Astragalus mongholicus Seedlings."Biomolecules. 2020 Apr;10(4):504 59. [IF=4.759] Wenjie Wu et al."An analytical strategy for accurate, rapid and sensitive quantitative analysis of isoflavones in traditional Chinese medicines using ultra-high performance supercritical fluid chromatography: Take Radix Puerariae as an example."J Chromato 60. [IF=4.703] Wang Qiao et al."Preparation and Pharmacokinetic Study of Daidzein Long-Circulating Liposomes."Nanoscale Res Lett. 2019 Dec;14(1):1-10 61. [IF=4.411] Yuqi Mei et al."A Method to Study the Distribution Patterns for Metabolites in Xylem and Phloem of Spatholobi Caulis."Molecules. 2020 Jan;25(1):167 62. [IF=4.411] Liqing Yin et al."Neuroprotective Potency of Tofu Bio-Processed Using Actinomucor elegans against Hypoxic Injury Induced by Cobalt Chloride in PC12 Cells."Molecules. 2021 Jan;26(10):2983 63. [IF=4.411] Liyu Luo et al."Integrated Phytochemical Analysis Based on UPLC-MS and Network Pharmacology Approaches to Explore the Quality Control Markers for the Quality Assessment of Trifolium pratense L.."Molecules. 2020 Jan;25(17):3787 64. [IF=3.935] Yanchao Xing et al."An effective strategy for distinguishing the processing degree of Polygonum multiflorum based on the analysis of substance and taste by LC-MS, ICP-OES and electronic tongue."J Pharmaceut Biomed. 2021 Oct;205:114328 65. [IF=3.935] Yuqi Mei et al."Qualitative and quantitative analysis of the major constituents in Spatholobi Caulis by UFLC-Triple TOF-MS/MS and UFLC-QTRAP-MS/MS."J Pharmaceut Biomed. 2021 Feb;194:113803 66. [IF=3.935] Zhengchao Ji et al."Global identification and quantitative analysis of representative components of Xin-Nao-Kang Capsule, a traditional Chinese medicinal formula, by UHPLC-Q-TOF-MS and UHPLC-TQ-MS."J Pharmaceut Biomed. 2021 May;198:114002 67. [IF=3.645] Hongmin Zhang et al."Simultaneous determination of five isoflavones in rat plasma by LC-MS/MS: Comparative pharmacokinetic characteristics of Puerariae lobatae radix in normal and type 2 diabetic rats."J Sep Sci. 2019 Aug;42(16):2592-2601 68. [IF=3.512] Yan Cheng et al."Comparison of the Extraction Efficiency of Isoflavone Compounds from Puerariae lobatae by Ionic Liquids with 11 Anions and 8 Imidazolium-Based Cations."Acs Omega. 2020;5(15):8962–8971 69. [IF=3.422] Wei Bin et al."Discovery of novel glycoside hydrolases from C-glycoside-degrading bacteria using sequence similarity network analysis."J Microbiol. 2021 Oct;59(10):931-940 70. [IF=3.373] Wanning Chen et al."The composition differences between small black beans and big black beans from different habitats and its effects on the processing of Polygonum multiflorum."Phytochem Analysis. 2021 Sep;32(5):767-779 71. [IF=3.361] Mengmeng Yuan et al."The interaction of dietary flavonoids with xanthine oxidase in vitro: molecular property-binding affinity relationship aspects."Rsc Adv. 2019 Apr;9(19):10781-10788 72. [IF=3] Run-Jia XU et al."3′-Methoxydaidzein exerts analgesic activity by inhibiting voltage-gated sodium channels."Chin J Nat Medicines. 2019 Jun;17:413 73. [IF=3] Qu Lala et al."Phenotypic assessment and ligand screening of ETA/ETB receptors with label-free dynamic mass redistribution assay."N-S Arch Pharmacol. 2020 Jun;393(6):937-950 74. [IF=2.984] Chenkai Wang et al."Comparative transcriptome analysis of roots, stems, and leaves of Pueraria lobata (Willd.) Ohwi: identification of genes involved in isoflavonoid biosynthesis."Peerj. 2021 Feb;9:e10885 75. [IF=2.742] Guo Yingyu et al."Isolation and identification of a human intestinal bacterium capable of daidzein conversion."Fems Microbiol Lett. 2021 May;368(8): 76. [IF=1.797] Bihui Liu et al."Effects of Lactobacillus plantarum CQPC01‐fermented soybean milk on activated carbon‐induced constipation through its antioxidant activity in mice."Food Sci Nutr. 2019 Jun;7(6):2068-2082 77. [IF=3.645] Jingbin Chen et al.Screening for potential quality markers of Callerya nitida var. hirsutissima. Z.Wei based on components profile, pharmacokinetics, and anti-inflammatory study.Journal Of Separation Science.2021 Nov 02 78. [IF=7.514] Chengwen Lu et al."Effect of pulsed electric field on soybean isoflavone glycosides hydrolysis by β-glucosidase: Investigation on enzyme characteristics and assisted reaction."Food Chem. 2022 Jun;378:132032 79. [IF=6.475] Pin Chen et al."The bioavailability of soy isoflavones in vitro and their effects on gut microbiota in the simulator of the human intestinal microbial ecosystem."Food Res Int. 2021 Dec;:110868 80. [IF=7.514] Xuefeng Chen et al."Quantitative analyses for several nutrients and volatile components during fermentation of soybean by Bacillus subtilis natto."Food Chem. 2021 Dec;:131725 81. [IF=11.614] Pengfei He et al."Structural mechanism of a dual-functional enzyme DgpA/B/C as both a C-glycoside cleaving enzyme and an O- to C-glycoside isomerase."Acta Pharmaceutica Sinica B. 2022 May;: 82. [IF=7.514] Jie Meng et al."Conduction of a chemical structure-guided metabolic phenotype analysis method targeting phenylpropane pathway via LC-MS: Ginkgo biloba and soybean as examples."FOOD CHEMISTRY. 2022 Oct;390:133155 83. [IF=6.576] Junkun Pan et al."Inhibition of Dipeptidyl Peptidase-4 by Flavonoids: Structure–Activity Relationship, Kinetics and Interaction Mechanism."Frontiers in Nutrition. 2022; 9: 892426 84. [IF=7.514] Rui Wang et al."Functionalization of soy residue (okara) by enzymatic hydrolysis and LAB fermentation for B2 bio-enrichment and improved in vitro digestion."Food Chem. 2022 Sep;387:132947 |
微信搜索化工百科或扫描下方二维码,添加化工百科小程序,随时随地查信息!