中文名 | 大黄素 |
英文名 | Emodin |
别名 | 大黄素 大黄浸膏粉 泻鼠李树皮 朱砂莲甲素 大黄素(标准品) 青蒿提取物(液) 大黄素EMODIN 双醋瑞因杂质A(大黄素) 蛋白激酶CK2抑制剂(EMODIN) |
英文别名 | Emodin C.I. 75440 C.I. Natural Yellow 14 emodin from frangula bark 6-METHYL-1,3,8-TRIHYDROXYANTHRAQUINONE 1,3,8-Trihydroxy-6-methylanthraquinone 6-METHYL-1,3,8-TRIHYDROXYANTHROQUINONE 1,3,8-TRIHYDROXY-6-METHYLANTHRAQUINONE 6-Methyl-1,3,8-trihydroxyanthraquinone 1,3,8-TRIHYDROXY-6-METHYL-9-10-ANTHRACENEDIONE 9,10-ANTHRACENEDIONE, 1,3,8-TRIHYDROXY-6-METHYL- |
CAS | 518-82-1 |
EINECS | 208-258-8 |
化学式 | C15H10O5 |
分子量 | 270.24 |
InChI | InChI=1/C15H10O5/c1-6-2-8-12(10(17)3-6)15(20)13-9(14(8)19)4-7(16)5-11(13)18/h2-5,16-18H,1H3 |
InChIKey | RHMXXJGYXNZAPX-UHFFFAOYSA-N |
密度 | 1.3280 (rough estimate) |
熔点 | 255°C (dec.)(lit.) |
沸点 | 373.35°C (rough estimate) |
水溶性 | <0.1 g/100 mL at 19 ºC |
溶解度 | DMSO: 可溶性 |
折射率 | 1.5000 (estimate) |
酸度系数 | 6.39±0.20(Predicted) |
存储条件 | 2-8°C |
敏感性 | Sensitive to light and air |
外观 | 粉末 |
颜色 | orange |
Merck | 14,3561 |
BRN | 1888141 |
物化性质 | 橙色针状结晶。熔点256-257℃(259-260℃)。溶于乙醇,略溶于乙醚、氯仿、苯,不溶于水。溶于苛性碱水溶液、碳本酸钠水溶液,氨溶液中显樱红色。 |
MDL号 | MFCD00001207 |
危险品标志 | Xi - 刺激性物品 |
风险术语 | 36/37/38 - 刺激眼睛、呼吸系统和皮肤。 |
安全术语 | S26 - 不慎与眼睛接触后,请立即用大量清水冲洗并征求医生意见。 S36 - 穿戴适当的防护服。 S37/39 - 戴适当的手套和护目镜或面具。 S36/37 - 穿戴适当的防护服和手套。 |
WGK Germany | 3 |
RTECS | CB7920600 |
FLUKA BRAND F CODES | 8-10-23 |
海关编号 | 29146990 |
上游原料 | 间甲酚 1,3-二硝基苯 2-甲基蒽醌 |
下游产品 | 原金丝桃素 Emodin 6-O-β-D-glucoside |
参考资料 展开查看 | 1. 陈帅 王慧竹 薛健飞 等. HPLC-DAD法同时测定四季三黄丸中9种成分[J]. 中成药 2016(8期):1727-1731. 2. 葛朝亮 程钢 余剑萍 许杜娟.“九蒸九晒”传统炮制对何首乌主要化学成分的影响[J].现代中药研究与实践 2017 31(03):43-47. 3. 孟雨婷, 李华, 陈志颖,等. 基于成分检测的大黄-蜇虫药对最佳配伍比例的研究[J]. 辽宁化工, 2020, v.49;No.459(01):32-36. 4. 江坤, 李璐, 李菁,等. 基于抗炎药效的中药榕须质量评价研究[J]. 中国药学杂志, 2016, 051(012):1033-1038. 5. 李灵玲, 蒲吉, LI,等. 大黄素促进结肠癌细胞自噬性凋亡的作用及其机制[J]. 华西药学杂志, 2017, 06(v.32):46-49 6. 王云龙, 郭海, 魏睦新. 大黄素对CCl4诱导小鼠肝纤维化的作用机制[J]. 中国现代中药, 2018, 20(04):402-408. 7. 郝宗艳, 李欣, 李玲. 大黄素对功能性消化不良大鼠相关指标影响的实验研究[J]. 新中医, 2017, 049(005):1-3. 8. 豆颖, 闫哲, 潘翔珍,等. 大黄素对口腔鳞癌细胞Tca8113抑制作用[J]. 医药论坛杂志, 2015(01):72-74. 9. 韦美金,黄娟,白俊其,蔡锡潮,丘小惠.大黄素对大鼠血清肝功能、肝脏转运蛋白及代谢酶UGT1A1表达的影响[J].时珍国医国药,2018,29(07):1551-1555. 10. 赵滋苗, 蔡宛如, 陆军,等. 大黄素对脓毒症大鼠血糖和胰岛素抵抗的影响[J]. 中国现代应用药学, 2016, 33(009):1115-1118. 11. 张丹参, 梅艳飞, 宋晓敏,等. 大黄结肠靶向微丸在大鼠胃肠道内的分布及释放方法学研究[J]. 神经药理学报, 2015, 5(005):20-27. 12. 张丹参, 梅艳飞, 宋晓敏,等. 大黄结肠靶向微丸的制备及处方优化[J]. 中草药, 2016, 47(008):1321-1326. 13. 李成职, 刘洋, 刘小红,等. 消痔方醇提工艺和颗粒制剂含量测定方法[J]. 青岛大学学报(工程技术版), 2018, 033(001):130-134. 14. 顾玲, 闫璟, 柯苗,等. 芦丁在聚大黄素/纳米氧化锌修饰碳糊电极上的电化学行为研究[J]. 化学研究与应用, 2017(10). 15. 张蕾, 郭晏华, 黄婷,等. 虎杖生品及不同炮制品中虎杖苷、白藜芦醇和大黄素含量[J]. 辽宁中医药大学学报, 2013, 015(011):56-59. 16. 支旭然 董占军 吴茵 等. HPLC同时测定肾康注射液中的4种成分[J]. 华西药学杂志 2017(03):297-299. 17. 李宵 吴茵 支旭然 等. UPLC-MS/MS法同时测定苦黄注射液中7种成分的含量[J]. 中国药房 2017 028(015):2108-2112. 18. 蔡芳, 任繁栋, 任达兵,等. 整合定性策略用于大黄素代谢物的高通量靶向鉴定[J]. 分析化学, 2019, 047(008):1212-1218. 19. 王亚洲, 吴洪文. 烫伤合剂质量标准研究[J]. 中国医院药学杂志, 2012, 32(021):1767-1769. 20. 林艳, 刘月新, 李春,等. 生/制何首乌HPLC指纹图谱结合模式识别与含量测定的质量控制研究[J]. 中国中医药信息杂志, 2018, 25(12):67-71. 21. 支旭然, 白万军, 王祁民,等. 肾康注射液的配伍稳定性考察[J]. 中国药师, 2016, 19(011):2155-2157. 22. 支旭然 刘洪涛 吴茵 等. UPLC-MS/MS法同时测定肾康注射液中7个有效成分[J]. 药物分析杂志 2017 037(001):37-42. 23. 杨国静 张珞琪 陈随清 等. 不同商品规格决明子的质量分析[J]. 中国现代中药 2018 v.20(08):963-967. 24. 周杨静,唐俊峰,高峰,卫培峰.基于“九蒸九晒”炮制法的何首乌主要化学成分含量变化及对大鼠肝脏的影响实验研究[J].中南药学,2020,18(04):543-548. 25. 徐艳, 张心怡, 狄留庆,等. 基于热熔挤出技术的虎杖提取物速释固体分散体制备研究[J]. 中草药, 2017(23):4865-4871. 26. 李红英 向极钎 龙澜 等. HPLC法测定大黄药材中5种游离蒽醌的含量[J]. 安徽农业科学 2013(12):5278-5279. 27. 程素盼 张敏敏 梁琰 等. HPLC-DAD-ESI-TOF/MS法分析安神补脑液中化学成分[J]. 中成药 2019 041(004):743-748. 28. 魏艳婷 张静宜 张华潭 等. HPLC法同时测定三黄滴丸中5种蒽醌类成分的含量[J]. 中国药房 2015. 29. 李晓花 郭允 李佳 袁琦 蒲晓辉 王高峰.RP-HPLC法同时测定三黄片中7种指标成分的含量[J].沈阳药科大学学报 2016 33(08):637-642. 30. 杨强 蒲晓辉 李晓花. 一清胶囊中7种指标成分的测定[J]. 华西药学杂志 2017(3). 31. 郭允, 陈永超, 李晓花,等. 牛黄解毒片中6种指标成分的含量测定[J]. 沈阳药科大学学报, 2016(6):454-458. 32. 刘全德,唐仕荣,宋慧,王营,邢洪伟.芦荟蒽醌类化合物的超声提取及其抗氧化性研究[J].食品与机械,2011,27(05):68-71. 33. 周军, 彭媚, 陈薇,等. 药用虎杖剩余物的化学组成与热解特性[J]. 环境工程学报, 2018, 12(12):229-237. 34. 陈静.pH响应的铜-大黄素脂质体的制备及其体外释放研究[J].江苏科技信息,2020,37(31):52-54. 35. 陆杰,王婷婷,梁琨,安叡,王新宏,陈颖.UPLC-LTQ-Orbitrap-MS法分析大承气汤化学成分[J].中成药,2020,42(12):3275-3280. 36. 宁一博,程龙,黄芷棋,贺润铖,孙建宁,董世芬.基于脂肪棕色化探究大黄素对老龄小鼠脂质代谢的影响[J].中南药学,2021,19(03):478-483. 37. 周桂,谢瑞芳,于天源,周昕.首乌藤指纹图谱的建立及3种成分的测定[J].中医药导报,2020,26(13):27-32. 38. 佘瑶瑶,刘自华,张颖,刘义梅,陈运中.湖北虎杖主要化学成分的含量分析及其与色差的相关性研究[J].食品安全质量检测学报,2021,12(03):960-967. 39. 李承浩,王萌,任晓亮.磺化杯6芳烃对4类中药单体成分增溶作用及其机制研究[J].中国现代中药,2020,22(12):2032-2038. 40. 王盼,储全根,轩云,蔡正银.抵当陷胸汤HPLC-MS指纹图谱研究[J].时珍国医国药,2020,31(12):2937-2940. 41. 汪颖舒,朱广灏,王冰,李杰荣,骆前飞,何修滢,赵佳逸,修彦凤.古法黑豆蒸晒与药典黑豆汁连续蒸对何首乌中12个成分含量的影响[J].中草药,2020,51(19):4972-4982. 42. 张明明. 大黄道地产区核心种质构建及优良种质筛选研究[D].北京中医药大学,2020. 43. Gao, Fangyuan, et al. "Cyclodextrin-based ultrasonic-assisted microwave extraction and HPLC-PDA-ESI-ITMSn separation and identification of hydrophilic and hydrophobic components of Polygonum cuspidatum: A green, rapid and effective process." Industrial Cro 44. Wang, Qi, et al. "Identification and characterization of the structure–activity relationships involved in UGT1A1 inhibition by anthraquinone and dianthrone constituents of Polygonum multiflorum." Scientific reports 7.1 (2017): 1-9. 45. Huang, Yongqian, et al. "The intervention mechanism of emodin on TLR3 pathway in the process of central nervous system injury caused by herpes virus infection." Neurological Research 43.4 (2021): 307-313.https://doi.org/10.1080/01616412.2020.1853989 46. Lin, Longfei, et al. "Inhibition of Mitochondrial Complex Function—The Hepatotoxicity Mechanism of Emodin Based on Quantitative Proteomic Analyses." Cells 8.3 (2019): 263.https://doi.org/10.3390/cells8030263 47. Qiu, Neng, et al. "Inclusion complex of emodin with hydroxypropyl-β-cyclodextrin: Preparation, physicochemical and biological properties." Journal of Molecular Liquids 289 (2019): 111151.https://doi.org/10.1016/j.molliq.2019.111151 48. Zhang, Ning, et al. "Emodin inhibits the proliferation of human breast cancer MCF-7 cells through activation of aryl hydrocarbon receptor." Frontiers in Pharmacology 11 (2020): 2372.https://doi.org/10.3389/fphar.2020.622046 49. LIU, Qing-Shan, et al. Novel Beta-Tubulin-Immobilized Nanoparticles Affinity Material for Screening β-Tubulin Inhibitors from a Complex Mixture. ACS applied materials & interfaces, 2017, 9.7: 5725-5732.https://doi.org/10.1021/acsami.6b13477 50. Huang, Xiya, Weixi Cai, and Baojun Xu. "Kinetic changes of nutrients and antioxidant capacities of germinated soybean (Glycine max L.) and mung bean (Vigna radiata L.) with germination time." Food chemistry 143 (2014): 268-276.https://doi.org/10.1016/j.foo 51. Zhou, Li-Hua, et al. "Label-free quantitative proteomics reveals fibrinopeptide B and heparin cofactor II as potential serum biomarkers in respiratory syncytial virus-infected mice treated with Qingfei oral liquid formula." Chin J Nat Med 16 (2018): 241-25 52. Zhou, Li-Hua, et al. "Label-free quantitative proteomics reveals fibrinopeptide B and heparin cofactor II as potential serum biomarkers in respiratory syncytial virus-infected mice treated with Qingfei oral liquid formula." Chin J Nat Med 16 (2018): 241-25 53. [IF=9.229] Qing-Shan Liu et al."Novel Beta-Tubulin-Immobilized Nanoparticles Affinity Material for Screening β-Tubulin Inhibitors from a Complex Mixture."Acs Appl Mater Inter. 2017;9(7):5725–5732 54. [IF=5.645] Fangyuan Gao et al."Cyclodextrin-based ultrasonic-assisted microwave extraction and HPLC-PDA-ESI-ITMSn separation and identification of hydrophilic and hydrophobic components of Polygonum cuspidatum: A green, rapid and effective process."Ind Crop Prod. 20 55. [IF=5.64] Wu Dousheng et al."Oleanolic Acid Induces the Type III Secretion System of Ralstonia solanacearum."Front Microbiol. 2015 Dec;0:1466 56. [IF=4.743] Hua Jun-yi et al."Emodin prevents intima thickness via Wnt4/Dvl-1/β-catenin signaling pathway mediated by miR-126 in balloon-injured carotid artery rats."Exp Mol Med. 2015 Jun;47(6):e170-e170 57. [IF=4.411] Yanling Zeng et al."Rapid Characterization of Components in Bolbostemma paniculatum by UPLC/LTQ-Orbitrap MSn Analysis and Multivariate Statistical Analysis for Herb Discrimination."Molecules. 2018 May;23(5):1155 58. [IF=4.366] Longfei Lin et al."Inhibition of Mitochondrial Complex Function—The Hepatotoxicity Mechanism of Emodin Based on Quantitative Proteomic Analyses."Cells-Basel. 2019 Mar;8(3):263 59. [IF=3.738] Selma Houchi et al."Investigation of common chemical components and inhibitory effect on GES-type β-lactamase (GES22) in methanolic extracts of Algerian seaweeds."Microb Pathogenesis. 2019 Jan;126:56 60. [IF=3.366] Wu Xingqiang et al."A Novel Selective Accelerated Solvent Extraction for Effective Separation and Rapid Simultaneous Determination of Six Anthraquinones in Tartary Buckwheat and Its Products by UPLC–DAD."Food Anal Method. 2015 May;8(5):1124-1132 61. [IF=3.361] Lailai Li et al."Development of a dual screening strategy to identify pro-angiogenic compounds from natural products: application on Tongmai Yangxin Pills."Rsc Adv. 2016 Dec;6(116):115308-115316 62. [IF=1.843] Ma Libin et al."Emodin ameliorates renal fibrosis in rats via TGF-β1/Smad signaling pathway and function study of Smurf 2."Int Urol Nephrol. 2018 Feb;50(2):373-382 63. [IF=1.773] Li-Hua ZHOU et al."Label-free quantitative proteomics reveals fibrinopeptide B and heparin cofactor II as potential serum biomarkers in respiratory syncytial virus-infected mice treated with Qingfei oral liquid formula."Chin J Nat Medicines. 2018 Apr;16:2 64. [IF=9.811] Manjie Gao et al."High-Crystallinity Covalent Organic Framework Synthesized in Deep Eutectic Solvent: Potentially Effective Adsorbents Alternative to Macroporous Resin for Flavonoids."Chem Mater. 2021;33(20):8036–8051 65. [IF=6.165] Neng Qiu et al."Inclusion complex of emodin with hydroxypropyl-β-cyclodextrin: Preparation, physicochemical and biological properties."J Mol Liq. 2019 Sep;289:111151 66. [IF=5.81] Zhang N et al."Emodin Inhibits the Proliferation of MCF-7 Human Breast Cancer Cells Through Activation of Aryl Hydrocarbon Receptor (AhR).."Front Pharmacol. 2020 Jan;11:622046-622046 67. [IF=5.81] Zhihui Yin et al."Rhein Relieves Oxidative Stress in an Aβ1-42 Oligomer-Burdened Neuron Model by Activating the SIRT1/PGC-1α-Regulated Mitochondrial Biogenesis."Front Pharmacol. 2021; 12: 746711 68. [IF=5.645] Li-Xia Dai et al."Ultrasound-assisted extraction of five anthraquinones from Rheum palmatum water extract residues and the antimicrobial activities."Ind Crop Prod. 2021 Apr;162:113288 69. [IF=4.759] Yueping Jiang et al."Application of multifold characteristic ion filtering combined with statistical analysis for comprehensive profiling of chemical constituents in anti-renal interstitial fibrosis I decoction by ultra-high performance liquid chromatogra 70. [IF=4.759] Yi Zhang et al."Screening of inhibitors against histone demethylation jumonji domain-containing protein 3 by capillary electrophoresis."J Chromatogr A. 2020 Feb;1613:460625 71. [IF=4.36] Li Lin et al."Study on the protection of water extracts of Polygoni Multiflori Radix and Polygoni Multiflori Radix Praeparata against NAFLD and its mechanism."J Ethnopharmacol. 2020 Apr;252:112577 72. [IF=4.142] Wang Chenxi et al."Systematic quality evaluation of Peiyuan Tongnao capsule by offline two-dimensional liquid chromatography/quadrupole-Orbitrap mass spectrometry and adjusted parallel reaction monitoring of quality markers."Anal Bioanal Chem. 2019 Nov;4 73. [IF=4.092] Shen Pan et al."Emodin Attenuates Acetaminophen-Induced Hepatotoxicity via the cGAS-STING Pathway."Inflammation. 2021 Aug;:1-14 74. [IF=3.943] Yuanyuan Liu et al."Emodin ameliorates ovalbumin-induced airway remodeling in mice by suppressing airway smooth muscle cells proliferation."Int Immunopharmacol. 2020 Nov;88:106855 75. [IF=3.935] Yanchao Xing et al."An effective strategy for distinguishing the processing degree of Polygonum multiflorum based on the analysis of substance and taste by LC-MS, ICP-OES and electronic tongue."J Pharmaceut Biomed. 2021 Oct;205:114328 76. [IF=3.935] Li Xie et al."Development of an UHPLC-MS/MS method for comparative pharmacokinetics of nine anthraquinones in rats and application to dosage conversion between different Semen Cassiae forms."J Pharmaceut Biomed. 2019 Sep;174:696 77. [IF=3.935] Zhengchao Ji et al."Global identification and quantitative analysis of representative components of Xin-Nao-Kang Capsule, a traditional Chinese medicinal formula, by UHPLC-Q-TOF-MS and UHPLC-TQ-MS."J Pharmaceut Biomed. 2021 May;198:114002 78. [IF=3.882] Kunpeng Yin et al."Lanthanide Metal–Organic Framework-Based Fluorescent Sensor Arrays to Discriminate and Quantify Ingredients of Natural Medicine."Langmuir. 2021;37(17):5321–5328 79. [IF=3.205] Jie Tang et al."Metabolite profiling of Shuganzhi tablets in rats and pharmacokinetics study of four bioactive compounds with liquid chromatography combined with electrospray ionization tandem mass spectrometry."J Chromatogr B. 2021 Aug;1179:122827 80. [IF=3] Qu Lala et al."Phenotypic assessment and ligand screening of ETA/ETB receptors with label-free dynamic mass redistribution assay."N-S Arch Pharmacol. 2020 Jun;393(6):937-950 81. [IF=2.401] Yongqian Huang et al."The intervention mechanism of emodin on TLR3 pathway in the process of central nervous system injury caused by herpes virus infection."Neurol Res. 2021;43(4):307-313 82. [IF=2.161] Jinjing Li et al."Enhanced hydrophilicity and antifouling performance of PES-C/emodin ultrafiltration membrane:."High Perform Polym. 0;(): 83. [IF=1.902] Chenxi Wang et al."Multiple component-pharmacokinetic studies on 10 bioactive constituents of Peiyuan Tongnao capsule using parallel reaction monitoring mode."Biomed Chromatogr. 2021 Oct;35(10):e5153 84. [IF=1.618] Tao Yi et al."Simultaneous Quantitation of Five Bioactive Ingredients in Raw and Processed Fallopia multiflora by Employing UHPLC-Q-TOF-MS."J Chromatogr Sci. 2019 Aug;57(7):618-624 85. [IF=0.986] Ji-le Lan et al."Q-marker Prediction Analysis of Rhubarb in Fengyin Decoction Based on Fingerprint and Network Pharmacology:."Nat Prod Commun. 2021;16(8): 86. [IF=6.165] Yaofen Li et al.Study on the effects of deep eutectic solvents as a reaction media on the micromorphology of hydrogen-substituted graphyne and its adsorption and electrochemical properties.J Mol Liq. 2021 Nov;:118177 87. [IF=4.432] Yanqing Wang et al.Emodin prevents renal ischemia-reperfusion injury via suppression of CAMKII/DRP1-mediated mitochondrial fission.Eur J Pharmacol. 2021 Nov;:174603 88. [IF=5.811] Kong Wei-Song et al."Beware of the Potential Risks for Polygoni Multiflori Caulis-Induced Liver Injury."Front Pharmacol. 2022 Apr;0:928 89. [IF=4.36] Zhenhui Guo et al."Study on the mechanism of Cortex Lycii on lung cancer based on network pharmacology combined with experimental validation."J Ethnopharmacol. 2022 Apr;:115280 90. [IF=3.645] Xi Zhou et al."Preparation of magnetic metal-organic framework MIL-101(Fe) and its application in the extraction of anthraquinones in rhubarb."JOURNAL OF SEPARATION SCIENCE |
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