中文名 | 尼日利亚菌素钠 |
英文名 | Nigericin sodium salt |
别名 | 尼日利亚菌素钠 尼日利亚菌素钠盐 尼日利亚霉素(钠盐) NIGERICIN(钠盐形式) 尼日利亚菌素,钠盐, 吸水链霉菌 尼日利亚菌素钠盐, 来源于吸水链霉菌 尼日利亚菌素钠盐,来源于链霉菌,吸湿性菌 尼日利亚菌素钠 NIGERICIN SODIUM SALT |
英文别名 | Nsc292567 Nigericin sodiuM sa Nigericin sodium salt Nigericin, monosodium salt Polyetherin A, Azalomycin M, Helixin C, Antibiotic K178, Antibiotic X-464 Antibiotic K178, Antibiotic X464, Azalomycin M, Helexin C, Polyetherin A Nigericin sodium salt,Antibiotic K178, Antibiotic X464, Azalomycin M, Helexin C, Polyetherin A Sodium (2R)-2-[(3S,6R)-6-[[(2S,4R,5R,7R,9R,10R)-2-[(5S)-5-[(2R,3S,5R)-5-[(2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]-3-methyloxolan-2-yl]-5-methyloxolan-2-yl]-9-methoxy-2,4,10-trimethyl-1,6-dioxaspiro[4.5]decan-7-yl]methyl]-3-methyloxan-2-yl]propanoate |
CAS | 28643-80-3 |
EINECS | 608-231-4 |
化学式 | C40H69NaO11 |
分子量 | 748.97 |
InChIKey | MOYOTUKECQMGHE-NTQCAYBPSA-M |
熔点 | approximate 255℃ |
沸点 | 779.9°Cat760mmHg |
溶解度 | 溶于氯仿、甲醇或乙醇 |
存储条件 | 2-8°C |
稳定性 | 从提供的购买之日起稳定2年。在DMSO或乙醇中的溶液可以在-20 ° 储存长达2个月。 |
外观 | 溶液 |
颜色 | White |
Merck | 13,6569 |
BRN | 3892398 |
MDL号 | MFCD00036825 |
体外研究 | Nigericin (0.1 µM) decreases inhibits proliferation and clonogenicity of H460 lung cancer cells in a dose dependent manner. Nigericin inhibits migration and invasion of H460 lung cancer cells. Nigericin (0.1-10 nM) has apparently a dual effect on cell volume, that is a shrinking effect at lower Nigericin concentrations and a swelling effect at higher concentrations. Nigericin (0.1-1 nM) significantly decreases cytosolic pH (pHi), and slightly increases the pHi at 5 and 10 nM. Nigericin exhibits higher toxicity on S18 cells than S26 cells, with IC 50 of 2.03±0.55 μM and 4.77±2.35 μM, respectively. Nigericin can selectively kill cancer stem cells in NPC in vitro. Nigericin dramatically reduces the migration ability of S18 and HONE-1 cells. Nigericin exhibits gteat toxicity for the HT29 and SW116 cell line with IC 50 of 12.92±0.25 μmol and 15.86±0.18 μmol. Nigericin also shows a decreased ability to form colonies under anchorage-independent conditions in a standard soft agar assay. |
体内研究 | Ngericin (4 mg/kg, i.p.) significantly reduces tumor growth and acts synergistically with the chemotherapeutic agent DDP, as shown by the tumor volumes. Nigericin markedly decreases Bmi-1 in vivo. Overexpression of Bmi-1 partially restores CSC content and metastatic ability of NPC cells under Nigericin treatment. The downregulation of Bmi-1 may be involved in the inhibitory effect of Nigericin on CSCs in NPC. |
危险品标志 | T - 有毒物品 |
风险术语 | R25 - 吞食有毒。 R36/37/38 - 刺激眼睛、呼吸系统和皮肤。 |
安全术语 | S26 - 不慎与眼睛接触后,请立即用大量清水冲洗并征求医生意见。 S36/37/39 - 穿戴适当的防护服、手套和护目镜或面具。 S45 - 若发生事故或感不适,立即就医(可能的话,出示其标签)。 |
危险品运输编号 | UN 3462 6.1/PG 3 |
WGK Germany | 3 |
RTECS | QT6840000 |
海关编号 | 29419090 |
Hazard Class | 6.1 |
参考资料 展开查看 | 1. [IF=4.098] Xueqin Jiang et al."A mitochondria-targeted two-photon fluorescent probe for sensing and imaging pH changes in living cells."Spectrochim Acta A. 2020 Jan;224:117435 |
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