异博定_化工百科

中文名	维拉帕米
英文名	verapamil
别名	异博定戊脉胺维拉帕米戊脉胺异博定维拉帕米杂质P 维拉帕米杂质N 5-((3,4-二甲氧基苯乙基)甲基氨基)-2-(3,4-二甲氧基苯基)-2-异丙基戊腈
英文别名	verapamil Verapamil 2-isopropyl- NSC 272306NA dl-Verapamil -2-isopropyl- 4-dimethoxy-alpha-(1-methylethyl)-l)- 5-((3,4-dimethoxyphenethyl)methylamino)-2-(3,4-dimethoxyphenyl)-2-isopropylv 2-[3,4-di(methoxy)phenyl]-5-[2-(3,4-dimethoxyphenyl)ethyl-methyl-amino]-2-isopropyl-pentanenitrile alpha-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-alpha-(1-methylethyl)benzeneacetonitrile Benzeneacetonitrile, a-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-a-(1-methylethyl)- (9CI) Benzeneacetonitrile, .alpha.-3-2-(3,4-dimethoxyphenyl)ethylmethylaminopropyl-3,4-dimethoxy-.alpha.-(1-methylethyl)-
CAS	52-53-9
EINECS	200-145-1
化学式	C27H38N2O4
分子量	454.61
InChI	InChI=1/C27H37N2O4/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6/h9-12,17-18,20H,7-8,13-16H2,1-6H3
密度	1.1267 (rough estimate)
熔点	25°C
沸点	243-246 °C (1.3 Pa)
折射率	1.5448
酸度系数	8.6(at 25℃)
存储条件	Keep in dark place,Inert atmosphere,Room temperature
物化性质	粘稠的淡黄色油状液体。沸点243-246℃（1.3Pa），折光率（nD25）1.5448。溶于苯、醚，易溶于低级醇、丙酮、乙酸乙酯、氯仿，难溶于已烷，不溶于水。其盐酸盐（[152-11-4]）为白色至类白色结晶性粉末。熔点138.5-140.5℃（分解）。易溶于甲醇、二甲基甲酰胺，溶于乙醇、异丙醇、丙酮、乙酸乙酯，不溶于氯仿。无臭，味苦。
上游原料	苯乙腈苯甲醚 2-溴丙烷溴丙烷 3,4-二甲氧基苯乙胺 3,4-二甲氧基苯乙腈
下游产品	5-氨基-2-(3,4-二甲氧基苯基)-2-异丙基戊腈 N -甲基- 4 -(3,4 -二甲氧基苯基)- 4 -氰基- 5 - 己基甲胺
参考资料展开查看	1. 李涛赵小亮聂颖兰等. CQ止痛复方中青藤碱和川芎嗪的脑通透性研究[J]. 药学学报 2019 v.54(12):186-193. 2. 陆佳璐, 邓丽娜. 姜黄素-色氨酸共无定型的制备及其在大鼠体内的药动学研究[J]. 中国药房, 2019(17):2348-2354. 3. Wang, Jinli, et al. "In vitro synergistic effect of baicalin with azithromycin against Staphylococcus saprophyticus isolated from francolins with ophthalmia." Poultry science 98.1 (2019): 373-380.https://doi.org/10.3382/ps/pey356 4. Wang, Xin, et al. "Differences of first-pass effect in the liver and intestine contribute to the stereoselective pharmacokinetics of rhynchophylline and isorhynchophylline epimers in rats." Journal of ethnopharmacology 209 (2017): 175-183.https://doi.org/1 5. [IF=4.384] Rong Huang et al."Surfactant-free solid dispersion of BCS class IV drug in an amorphous chitosan oligosaccharide matrix for concomitant dissolution in vitro - permeability increase."Eur J Pharm Sci. 2019 Mar;130:147 6. [IF=4.36] Xin Wang et al."Differences of first-pass effect in the liver and intestine contribute to the stereoselective pharmacokinetics of rhynchophylline and isorhynchophylline epimers in rats."J Ethnopharmacol. 2017 Sep;209:175 7. [IF=3.667] Huang Yuanjia et al."Molecular cloning and characterization of calmodulin-like protein CaLP from the Scleractinian coral Galaxea astreata."Cell Stress Chaperon. 2018 Nov;23(6):1329-1335 8. [IF=1.627] Yanming Xia et al."Transport mechanism of ursodeoxycholic acid in human placental BeWo cells."Biopharm Drug Dispos. 2018 Jul;39(7):335-343 9. [IF=4.384] Juanhong Zhang et al."Enhanced P-glycoprotein expression under high-altitude hypoxia contributes to increased phenytoin levels and reduced clearance in rats."Eur J Pharm Sci. 2020 Oct;153:105490 10. [IF=3.352] Jinli Wang et al."In vitro synergistic effect of baicalin with azithromycin against Staphylococcus saprophyticus isolated from francolins with ophthalmia."Poultry Sci. 2019 Jan;98:373 11. [IF=3.981] Xiao-Hang Liu et al."Comparison of the permeability between conjugated estrogens and atenolol in rat in situ single-pass intestinal perfusions model and in Caco-2 cell monolayers."J Drug Deliv Sci Tec. 2022 Feb;68:102786

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产品名: 维拉帕米去供应商网站查看询盘
CAS: 52-53-9
产地: 上海
规格: V875827
价格: 1g-1620,5g-5400,100mg-490,50mg-298,25mg-190
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产品名: 维拉帕米去供应商网站查看询盘
CAS: 52-53-9
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