普仑司特水合物

中文名	半水普仑司特
英文名	N-[4-Oxo-2-(1H-tetrazol-5-yl)-4H-1-benzopyran-8-yl]-4-(4-phenylbutoxy)benzamide hemihydrate
别名	普仑司特半水普仑司特普仑司特水合物普鲁司特水合物普鲁司特半水合物
英文别名	Onon Ultair RS-411 Ono-1078 SB-205312 Ono-RS-411 Pranlukast hydrate PRANLUKASTHEMIHYDRATE Ono-1070(monoNa salt) Pranlukast Hemihydrate N-[4-Oxo-2-(1H-tetrazol-5-yl)-4H-1-benzopyran-8-yl]-4-(4-phe... 8-[4(4-phenylbutoxy)benzoyl]amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran N-[4-oxo-2-(2H-tetrazol-5-yl)chromen-8-yl]-4-(4-phenylbutoxy)benzamide,hydrate N-[4-Oxo-2-(1H-tetrazol-5-yl)-4H-1-benzopyran-8-yl]-4-(4-phenylbutoxy)benzamide hemihydrate N-[4-Oxo-2-(1H-tetrazol-5-yl)-4H-1-benzopyran-8-yl]-4-(4-phenylbutoxy)-benzamide hemihydrate
CAS	150821-03-7
化学式	C27H25N5O5
分子量	499.53
InChI	InChI=1/2C27H23N5O4.H2O/c233-23-17-24(26-29-31-32-30-26)36-25-21(23)10-6-11-22(25)28-27(34)19-12-14-20(15-13-19)35-16-5-4-9-18-7-2-1-3-8-18;/h21-3,6-8,10-15,17H,4-5,9,16H2,(H,28,34)(H,29,30,31,32);1H2
溶解度	DMSO: ≥ 10 mg/mL
存储条件	-20°C
外观	白色固体
体外研究	In the radioligand binding assay, Pranlukast (ONO-1078) inhibits [ 3 H]LTE 4 , [ 3 H]LTD 4 , and [ 3 H]LTC 4 bindings to lung membranes with K i s of 0.63±0.11, 0.99±0.19, and 5640±680 nM, respectively. The antagonism of Pranlukast against [ 3 H]LTD 4 binding is competitive. In functional experiments, Pranlukast shows competitive antagonism against the LTC 4 - and LTD 4 -induced contractions of guinea pig trachea and lung parenchymal strips with a pA 2 range of 7.70 to 10.71. In the presence of an inhibitor of the bioconversion of LTC 4 to LTD 4 , Pranlukast also antagonizes the LTC 4 -induced contraction of guinea pig trachea (pA 2 =7.78). Pranlukast significantly reverses the LTD 4 -induced prolonged contraction without effect on the KCl- and BaCl 2 -induced contractions of guinea pig trachea. Oxygen-glucose deprivation (OGD)-induced nuclear translocation of CysLT 1 receptors is inhibited by pretreatment with the CysLT 1 receptor antagonist Pranlukast (10 μM). Pranlukast protects endothelial cells against ischemia-like injury. The effects of the CysLT 1 receptor antagonist Pranlukast and the 5-lipoxygenase inhibitor Zileuton on translocation are also assessed. The results show that Pranlukast, but not Zileuton, inhibits the translocation of the CysLT 1 receptor 6 h after OGD.
体内研究	Carrageenan (CAR, 5 mg per mouse) is injected i.p. 24 h before LPS (50 p,g per mouse) is injected i.v. Various doses of Pranlukast (ONO-1078; 40, 20, and 10 mmol/kg), AA-861 (20, 10, and 5 mmol/kg), Indomethacin (40 mmollkg), and the controls are injected s.c. into mice 30 min before they are challenged with 50 p,g of LPS. The maximum soluble doses are 0.6 mmol/mL in 10% DMSO for AA-861 and 1.2 mmol/mL in 10% ethanol for Pranlukast. These solutions are used as the maximum doses for the treatments. The mortality of mice is significantly decreased in AA-861- Pranlukast-treated mice relative to that in the control mice. Pretreatment with CAR (5 mg i.p.) renders the mice more sensitive to the effect of LPS. Although the survival rate of mice treated with each solvent is 20% at 72 h after LPS (50 p,g per mouse) administration, s.c. treatment with AA-861 (20 mmol/kg) or Pranlukast (40 mmol/kg) significantly increases the survival rate after the LPS administration (AA-861, P<0.001; Pranlukast, P<0.01).
危险品标志	Xn - 有害物品
风险术语	R22 - 吞食有害。 R36/37/38 - 刺激眼睛、呼吸系统和皮肤。
安全术语	S26 - 不慎与眼睛接触后，请立即用大量清水冲洗并征求医生意见。 S36/37 - 穿戴适当的防护服和手套。
WGK Germany	3
Hazard Class	IRRITANT

普仑司特水合物 - 配置溶液浓度参考

	1mg	5mg	10mg
1 mM	1.019 ml	5.097 ml	10.193 ml
5 mM	0.204 ml	1.019 ml	2.039 ml
10 mM	0.102 ml	0.51 ml	1.019 ml
5 mM	0.02 ml	0.102 ml	0.204 ml

最后更新：2024-01-02 23:10:35

普仑司特水合物 - 简介

半水普仑司特（H2SO4）是一种无色液体，常温下呈油状，具有强酸性。以下是关于半水普仑司特的一些性质、用途、制法和安全信息的介绍：

性质：
强酸性：半水普仑司特是一种强酸，能与碱反应并产生热量。
吸湿性：半水普仑司特具有吸湿性，容易吸收水分。

用途：
实验室应用：半水普仑司特广泛用于实验室中的化学分析、合成和处理工作，如制备其他化合物、调节pH等。
工业用途：它在工业上被用作制备多种化学品，如肥料、酸洗钢铁、炼油和制药工业等。

制法：
半水普仑司特的制备一般通过以下步骤：
将浓硫酸和适量的水混合。
在配制过程中，要小心将浓硫酸慢慢倒入水中，而不是反过来，以免产生剧烈的放热反应。

安全信息：
酸性：半水普仑司特是一种强酸，使用时必须小心，避免直接接触皮肤、眼睛和呼吸道。
腐蚀性：它对许多物质具有腐蚀性，应避免与其他化学物质或可燃物接触。
防护措施：在使用半水普仑司特时，应佩戴适当的防护眼镜、手套和防护服，同时确保使用于通风良好的实验室环境中。

最后更新：2024-04-09 21:01:54

上海吉至生化科技有限公司

现货供应

产品名: 普鲁司特半水合物去供应商网站查看询盘
CAS: 150821-03-7
产地: 中国上海
包装: 50mg
规格: 99%
价格: 598.00
库存: 现货
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产品描述: 中文名：普鲁司特半水合物英文名:Pranlukast hemihydrate CAS:150821-03-7 规格:99% 产地:中国上海

上海麦克林生化科技股份有限公司

现货供应

产品名: Pranlukast hemihydrate 去供应商网站查看询盘
CAS: 150821-03-7
产地: 上海
规格: P882129
价格: 50mg-667,100mg-1121
库存: 7天内发货
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上海源叶生物科技有限公司

产品名: Pranlukast hemihydrate 去供应商网站查看询盘
CAS: 150821-03-7
产地: 上海
规格: 99%
价格: 50mg 600,100mg 1000
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