木兰花碱盐酸盐
木兰花碱((6aS)-1,11-dihydroxy-2,10-dimethoxy-6,6-dimethyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolinium chloride)
CAS: 6681-18-1
化学式: C20H24NO4.Cl
| 中文名 | 木兰花碱 |
| 英文名 | (6aS)-1,11-dihydroxy-2,10-dimethoxy-6,6-dimethyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolinium chloride |
| 别名 | 木兰碱 木兰花碱 氯化木兰碱 氯化木兰花碱 木兰花碱盐酸盐 木兰花碱(氯化物) 氯化木兰花碱对照品, 氯化木兰花碱(标准品) |
| 英文别名 | Nsc150443 Escholine chloride Magnoflorine chlori Thalictrine chloride Magnoflorine, chloride (+)-Magnoflorine chloride Corytuberine methochloride (6aS)-1,11-dihydroxy-2,10-dimethoxy-6,6-dimethyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolinium chloride (6aS)-5,6,6a,7-Tetrahydro-1,11-dihydroxy-2,10-dimethoxy-6,6-dimethyl-4H-dibenzo[de,g]quinolinium chloride |
| CAS | 6681-18-1 |
| 化学式 | C20H24NO4.Cl |
| 分子量 | 377.866 |
| InChI | InChI=1/C20H23NO4.ClH/c1-21(2)8-7-12-10-15(25-4)20(23)18-16(12)13(21)9-11-5-6-14(24-3)19(22)17(11)18;/h5-6,10,13H,7-9H2,1-4H3,(H-,22,23);1H/t13-;/m0./s1 |
| 熔点 | 236-237℃ |
| 比旋光度 | +220.1°（methanol） |
| 溶解度 | 可溶于甲醇、乙醇、DMSO等有机溶剂 |
| 存储条件 | 2-8°C |
| 外观 | 大多数生物碱是结晶形固体；有些是非结晶形粉末；还有少数在常温时为液体 |
| 物化性质 | 白色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于辛夷，木兰科植物望春花Magnolia biondii Pamp.、玉兰Magnolia denudata Desv.或武当玉兰Magnolia sprengeri Pamp.的干燥花蕾。 |
| MDL号 | MFCD09031380 |
| 参考资料 展开查看 | 1. 闫琦 李莉 刁娟娟 等. HPLC法同时测定黑果小檗根中7种成分的含量[J]. 中药材 2019年42卷7期 1584-1588页 MEDLINE ISTIC PKU 2020. 2. 白荣. HPLC法测定三才封髓丸中地黄苷A 地黄苷D 黄柏碱和木兰花碱[J]. 现代药物与临床 2015 11(11):1324-1327. 3. 金锋, 任玉珍, 陈彦琳,等. 巴豆生物碱部位HPLC特征指纹图谱研究[J]. 中国实验方剂学杂志, 2013, 19(002):90-93. 4. 张朝辉,谷陟欣,刘婧靖,陈应庄,陈波,马铭.直喷离子化质谱简单快速鉴别关木通[J].分析化学,2017,45(08):1143-1148. 5. 刘洋, 隗丽, 李雪莲,等. 离体法及在体法对黄连水煎液中肠吸收多成分的初步研究[J]. 中国中药杂志, 2017(8). 6. 刘越滇, 蔡欣廷, 倪文颖,等. 黄连提取物的中药生物药剂学分类系统探讨[J]. 中国处方药, 2019, 017(011):22-23. 7. 丁影.厚朴炮制前后指纹图谱及主要成分含量变化的研究[J].中国药师,2020,23(09):1745-1750. 8. 唐明,高霞,耿婷,王佳佳,陈夏霖,曹亮,王振中,肖伟.基于HPLC-Q-TOF-MS/MS技术的七味通痹口服液化学成分分析[J].中草药,2021,52(08):2226-2236. 9. Guo, Shuai, et al. "Magnoflorine ameliorates lipopolysaccharide-induced acute lung injury via suppressing NF-κB and MAPK activation." Frontiers in pharmacology 9 (2018): 982.https://doi.org/10.3389/fphar.2018.00982 10. Li, Qiao-Qiao, et al. "Evaluation of the interactions between platelets and alkaloids by frontal analysis capillary electrophoresis using polyvinyl alcohol-coated capillary." Chromatographia 81.3 (2018): 509-516.https://doi.org/10.1007/s10337-018-3476-6 11. Xu, Jun. "Improved approaches and strategies for analyzing decoctions of medicinal herbs." (2016). 12. [IF=4.759] Guang Yang et al."A modification on the vector cosine algorithm of Similarity Analysis for improved discriminative capacity and its application to the quality control of Magnoliae Flos."J Chromatogr A. 2017 Oct;1518:34 13. [IF=4.411] Jinjun Shan et al."Liquid Chromatography Coupled with Linear Ion Trap Hybrid OrbitrapMass Spectrometry for Determination of Alkaloids in Sinomeniumacutum."Molecules. 2018 Jul;23(7):1634 14. [IF=4.147] Zhe Cai et al."Magnoflorine with hyaluronic acid gel promotes subchondral bone regeneration and attenuates cartilage degeneration in early osteoarthritis."Bone. 2018 Nov;116:266 15. [IF=3.935] Ka-Yan Kwok et al."Quality evaluation of commercial Huang-Lian-Jie-Du-Tang based on simultaneous determination of fourteen major chemical constituents using high performance liquid chromatography."J Pharmaceut Biomed. 2013 Nov;85:239 16. [IF=2.896] Qi Yun et al."UPLC-Q-TOF/MS characterization, HPLC fingerprint analysis and species differentiation for quality control of Nigella glandulifera Freyn et Sint seeds and Nigella sativa L. seeds."Anal Methods-Uk. 2014 Jun;6(13):4845-4852 17. [IF=2.044] Li Qiao-Qiao et al."Evaluation of the Interactions Between Platelets and Alkaloids by Frontal Analysis Capillary Electrophoresis Using Polyvinyl Alcohol-Coated Capillary."Chromatographia. 2018 Mar;81(3):509-516 18. [IF=6.023] Maiquan Li et al."Discovery of Keap1−Nrf2 small−molecule inhibitors from phytochemicals based on molecular docking."Food Chem Toxicol. 2019 Nov;133:110758 19. [IF=5.645] Xiaojin Peng et al."Development of a novel functionality for a highly efficient imidazole-based ionic liquid non-aqueous solvent system for the complete extraction of target alkaloids from Phellodendron amurense Rupr. under ultrasound-assisted conditions. 20. [IF=4.759] Rong Wang et al."Integration of micro-fractionation, high-performance liquid chromatography-ultraviolet detector-charged aerosol detector-mass spectrometry analysis and cellular dynamic mass redistribution assay to accelerate alkaloid drug discovery."J Ch 21. [IF=3] Qu Lala et al."Phenotypic assessment and ligand screening of ETA/ETB receptors with label-free dynamic mass redistribution assay."N-S Arch Pharmacol. 2020 Jun;393(6):937-950 22. [IF=1.902] Ting Zhang et al."The influence of essential oils from ZhaLi NuSi Prescription on the pharmacokinetics of its non-volatile components in normal rats."Biomedical Chromatography. 2021 Oct 21 23. [IF=3.373] Kewei Zhang et al."Discrimination between raw and ginger juice processed Magnoliae officinalis cortex based on HPLC and Heracles NEO ultra-fast gas phase electronic nose."Phytochemical Analysis. 2022 Mar 22 24. [IF=1.902] Mengyu Qian et al."Metabolic characteristics and pharmacokinetic differences of Qiwei Tongbi oral liquid in rheumatoid arthritis rats."BIOMEDICAL CHROMATOGRAPHY. 2022 Apr 13 |
木兰花碱盐酸盐 - 简介
木兰花碱是一种天然产物，化学上属于酮类碱。它主要存在于木兰科植物的根皮和根茎中。
木兰花碱也可以用于中药配方中，具有抗菌、抗炎、镇痛、止咳等药理作用。
木兰花碱的制法主要包括提取和纯化过程。通常使用溶剂抽提法或蒸馏法提取木兰花中的碱类物质，并通过进一步的纯化步骤来得到纯度较高的木兰花碱。其中的提取溶剂应根据具体的实验条件选择合适的溶剂，如乙醇、丙酮等。
木兰花碱可能对皮肤和眼睛有刺激性，在接触时应注意避免直接暴露，使用时应佩戴防护手套、护目镜等个人防护装备。另外，在制备过程中应注意配比和实验条件，遵守实验室安全操作规范，确保操作环境安全。
木兰花碱也可以用于中药配方中，具有抗菌、抗炎、镇痛、止咳等药理作用。
木兰花碱的制法主要包括提取和纯化过程。通常使用溶剂抽提法或蒸馏法提取木兰花中的碱类物质，并通过进一步的纯化步骤来得到纯度较高的木兰花碱。其中的提取溶剂应根据具体的实验条件选择合适的溶剂，如乙醇、丙酮等。
木兰花碱可能对皮肤和眼睛有刺激性，在接触时应注意避免直接暴露，使用时应佩戴防护手套、护目镜等个人防护装备。另外，在制备过程中应注意配比和实验条件，遵守实验室安全操作规范，确保操作环境安全。
最后更新：2024-04-09 20:52:54
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