中文名 | 棕榈酰-L-左旋肉碱 |
英文名 | Palmitoyl-L-carnitine |
别名 | 棕榈酰-L-左旋肉碱 |
英文别名 | C02990 Palmitylcarnitine Palmitoyl-L-carnitine Palmitoyl L-carnitine Hexadecanoylcarnitine O-palmitoyl-L-carnitine (-)-[(R)-3-Carboxylato-2-(palmitoyloxy)propyl]trimethylaminium (2R)-3-Carboxylato-N,N,N-trimethyl-2-[(1-oxohexadecyl)oxy]-1-propanaminium 1-PropanaMiniuM, 3-carboxy-N,N,N-triMethyl-2-[(1-oxohexadecyl)oxy]-, inner salt, (2R)- |
CAS | 2364-67-2 |
化学式 | C23H45NO4 |
分子量 | 399.61 |
存储条件 | 2-8°C |
BRN | 4152034 |
体外研究 | L-Palmitoylcarnitine (1 µM) inhibits K ATP channel activity, without affecting the single channel conductance, through interaction with Kir6.2. L-Palmitoylcarnitine simultaneously enhances the ATP sensitivity of the channel (IC 50 fell from 62 to 30 µM). Modulation of the membrane lipid environment caused by L-Palmitoylcarnitine alters the K ATP channel function mainly through the interaction with endogenous PI cascade, especially PIP2. |
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