毛兰素
毛兰素(Erianin)
CAS: 95041-90-0
化学式: C18H22O5
| 中文名 | 毛兰素 |
| 英文名 | Erianin |
| 别名 | 毛兰素 毛兰素对照品 ERIANIN 毛兰素 2-甲氧基-5-(3,4,5-三甲氧基苯乙基)苯酚 2-甲氧基-5-[2-(3,4,5-三甲氧基苯基)乙基]苯酚 |
| 英文别名 | Erianin Erianin 95041-90-0 3'-Hydroxy-3,4,4',5-tetraMethoxybibenzyl 2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)ethyl]phenol 2-Methoxy-5-[2-(3,4,5-trimethoxyphenyl)ethyl]benzolol PHENOL, 2-METHOXY-5-[2-(3,4,5-TRIMETHOXYPHENYL)ETHYL]- |
| CAS | 95041-90-0 |
| EINECS | 1312995-182-4 |
| 化学式 | C18H22O5 |
| 分子量 | 318.36 |
| InChI | InChI=1/C18H22O5/c1-20-15-8-7-12(9-14(15)19)5-6-13-10-16(21-2)18(23-4)17(11-13)22-3/h7-11,19H,5-6H2,1-4H3 |
| 密度 | 1.147 |
| 沸点 | 439.1±40.0 °C(Predicted) |
| 闪点 | 219.4°C |
| 蒸汽压 | 2.54E-08mmHg at 25°C |
| 溶解度 | 溶于氯仿等脂溶性溶剂，难溶于水 |
| 折射率 | 1.553 |
| 酸度系数 | 9.99±0.10(Predicted) |
| 存储条件 | 2-8°C |
| 外观 | 白色粉末或结晶 |
| 物化性质 | 溶于氯仿等脂溶性溶剂，难溶于水 来源于鼓槌石斛 |
| MDL号 | MFCD06795132 |
| 体外研究 | Erianin is often used as antipyretic and analgesic agent. Erianin belongs to bibenzyl derivatives in structure, with the activity of anti-virus, anti-bacterial, as well as anti-benign prostatic hyperplasia. Erianin has obvious damage on 2LL-IDO cells, Erianin basically has no cytotoxicity on human normal liver cell line L02, and cell viability is maintained at around 85%. Erianin inhibits the growth of HeLa cells and induces apoptosis in a dose‑ and time‑dependent manner, inducing cell cycle arrest at the G2/M stage. Erianin treatment also increases the expression of Bax and caspase‑3, but decreases levels of Bcl‑2 and phosphorylated‑ERK1/2. |
| 海关编号 | 29089990 |
| 上游原料 | 3,4,5-三甲氧基苯甲醛 |
| 参考资料 展开查看 | 1. 林涛, 耿慧春, 李茂萱,等. 毛兰素纯度标准样品的研制[J]. 农产品质量与安全, 2018(6). 2. 赵群,范伶林,刘迎香,毕云,郭健,潘龙瑞,谭艳,余贤军.毛兰素通过活化JNK通路诱导乳腺癌细胞凋亡的实验研究[J].湖北医药学院学报,2020,39(05):419-426+431. 3. Dou, Bo, et al. "Anti-inflammation of Erianin in dextran sulphate sodium-induced ulcerative colitis mice model via collaborative regulation of TLR4 and STAT3." Chemico-biological interactions 324 (2020): 109089.https://doi.org/10.1016/j.cbi.2020.109089 4. Zhenghui Wan, Qingjun Huang，Study on chemical constituents of different species of Dendrobium，E3S Web Conf. 165 05026 (2020). DOI: 10.1051/e3sconf/202016505026 5. Yu, Zengyang, et al. "Erianin inhibits high glucose-induced retinal angiogenesis via blocking ERK1/2-regulated HIF-1α-VEGF/VEGFR2 signaling pathway." Scientific reports 6.1 (2016): 1-15.https://doi.org/10.1038/srep34306 6. Yu, Zengyang, et al. "Erianin inhibits high glucose-induced retinal angiogenesis via blocking ERK1/2-regulated HIF-1α-VEGF/VEGFR2 signaling pathway." Scientific reports 6.1 (2016): 1-15.https://doi.org/10.1038/srep34306 7. [IF=3.998] Yu Zengyang et al."Erianin inhibits high glucose-induced retinal angiogenesis via blocking ERK1/2-regulated HIF-1α-VEGF/VEGFR2 signaling pathway."Sci Rep-Uk. 2016 Sep;6(1):1-15 8. [IF=3.266] Jing Sun et al."Erianin inhibits the proliferation of T47D cells by inhibiting cell cycles, inducing apoptosis and suppressing migration."Am J Transl Res. 2016; 8(7): 3077–3086 9. [IF=13.493] Chen Peng et al."Erianin, a novel dibenzyl compound in Dendrobium extract, inhibits lung cancer cell growth and migration via calcium/calmodulin-dependent ferroptosis."Signal Transduct Tar. 2020 May;5(1):1-11 10. [IF=10.435] Mo Canlong et al."Development of erianin-loaded dendritic mesoporous silica nanospheres with pro-apoptotic effects and enhanced topical delivery."J Nanobiotechnol. 2020 Dec;18(1):1-14 11. [IF=6.023] Hualing Xie et al."Synergistic cytotoxicity of erianin, a bisbenzyl in the dietetic Chinese herb Dendrobium against breast cancer cells."Food Chem Toxicol. 2021 Mar;149:111960 12. [IF=5.81] Yu Xiang et al."Natural Product Erianin Inhibits Bladder Cancer Cell Growth by Inducing Ferroptosis via NRF2 Inactivation."Front Pharmacol. 2021; 12: 775506 13. [IF=4.162] Yihan Sun et al."Dual Targeting of Cell Growth and Phagocytosis by Erianin for Human Colorectal Cancer."Drug Des Dev Ther. 2020; 14: 3301–3313 14. [IF=3.723] Bo Dou et al."Anti-inflammation of Erianin in dextran sulphate sodium-induced ulcerative colitis mice model via collaborative regulation of TLR4 and STAT3."Chem-Biol Interact. 2020 Jun;324:109089 15. [IF=2.926] Zhang Peng et al."Exploration of the Tolerance Ability of a Cell-Free Biosynthesis System to Toxic Substances."Appl Biochem Biotech. 2019 Dec;189(4):1096-1107 16. [IF=4.799] Xueke Li et al."Erianin Controls Collagen-Mediated Retinal Angiogenesis via the RhoA/ROCK1 Signaling Pathway Induced by the alpha2/beta1 Integrin-Collagen Interaction."Invest Ophth Vis Sci. 2022 Jan;63(1):27-27 17. [IF=2.01] Pang Xuecheng et al."Erianin Suppresses Endometrial Cancer Progression by Regulating the miR-661/BOK Axis."Rev Bras Farmacogn. 2021 Dec;:1-9 |
供应商列表
提供多种规格现货供应
产品名: 毛兰素(10mM in DMSO,无菌) 去供应商网站查看 询盘CAS: IE05801
产地: 北京
包装: 1ml/瓶
规格: IE05801-1ml
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库存: 现询
电话: 010-50973130
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产品描述: 产品覆盖：小分子化合物、分析对照品、染色试剂、生化试剂盒、细胞生物学、分子生物学、抗体、蛋白、多肽、ELISA试剂盒、微生物培养、化学合成、仪器耗材、CRO技术 更多
提供多种规格现货供应
产品名: 毛兰素(10mM in DMSO,无菌) 去供应商网站查看 询盘CAS: IE05801
产地: 北京
包装: 1ml/瓶
规格: IE05801-1ml
价格: 电话、微信、QQ、邮件
库存: 现询
电话: 010-50973130
手机: 17801761073(微信同号)
电子邮件: 3193328036@qq.com
QQ: 3193328036
微信: 17801761073
产品描述: 产品覆盖：小分子化合物、分析对照品、染色试剂、生化试剂盒、细胞生物学、分子生物学、抗体、蛋白、多肽、ELISA试剂盒、微生物培养、化学合成、仪器耗材、CRO技术 更多
毛兰素的上游原料
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毛兰素 2-Ethoxybenzimidohydrazide 副肾素 11-Dehydroxyisomogroside V 乙基α-D-葡萄糖苷 L-1-CHLORO-3-PHENYL-3-(P-TOLUOLSULFONAMIDO)-2-BUTANONE GADOLINIUM(III) 17963-32-5 4-ANISIDINE-2,5-DISULFONIC ACID 2-METHYLNAPHTHOL[1,2-D]THIAZOLE
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