Tebipenem exhibits slow tight-binding inhibition at low micromolar concentrations versus the chromogenic substrate nitrocefin, and apparent K m and k cat values of 0.8 μM and 0.03 min -1 , respectively. Tebipenem shows potent activity against B. pseudomallei , with MIC 50 and MIC 90 values of both 2 mg/L. Tebipenem shows good activity against S. pneumoniae , with the MIC range of ≤0.25 μg/mL in all of the S. pneumoniae isolates.