中文名 | Lodoxamide |
英文名 | Lodoxamide |
别名 | 洛草氨酸 |
英文别名 | Lodoxamide Lodoxamida Lodoxamidum Unii-spu695od73 Lodoxamidum [inn-latin] Lodoxamida [inn-spanish] N,N'-(2-Chlor-5-cyan-3-phenylen)dioxamsaeure 2,2'-[(2-Chloro-5-cyano-1,3-phenylene)diimino]bis[2-oxoacetic acid] Acetic acid, 2,2'-((2-chloro-5-cyano-1,3-phenylene)diimino)bis(2-oxo- |
CAS | 53882-12-5 |
化学式 | C11H6ClN3O6 |
分子量 | 311.63 |
密度 | 1.78±0.1 g/cm3(Predicted) |
熔点 | 212° (dec) |
酸度系数 | 2.07±0.50(Predicted) |
存储条件 | 2-8℃ |
体外研究 | Lodoxamide inhibits compound 48/80-induced histamine release and ionophore-induced 45 Ca influx with associated histamine release in purified rat peritoneal mast cells. The chemotactic response of eosinophils to fMLP as well as to IL-5 is significant and dose-dependent inhibited by Lodoxamide. Lodoxamide is also able to strongly inhibit the release of eosinophil peroxidase after IgA-dependent activation and, to a lesser extent, the release of eosinophil cationic protein and eosinophil-derived neurotoxin. |
体内研究 | Lodoxamide has been demonstrated to have cromolyn-like activity when studied in the rat peritoneal mast cell assay (PCA) model3 and in Ascaris antigen-sensitized rhesus monkeys. When given intravenously, orally, or intrabronchially by aerosol, lodoxamide significantly inhibits the increased respiratory frequency and decreased tidal volume induced by antigen challenge in Ascaris-sensitized. anesthetized rhesus monkeys. Addition of lodoxamide tromethamine to Euro-Collins or University of Wisconsin solution results in a marked decrease in lung reperfusion injury as demonstrated by increased oxygenation, decreased microvascular permeability, and increased compliance. Patients treated with lodoxamide tromethamine demonstrate an improvement in daytime breathing difficulty, cough, sputum production, and sleep. |
上游原料 | 4-氯-3,5-二硝基苯甲酸 草酰氯单乙酯 4-氯-3,5-二硝基苯甲腈 |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 3.209 ml | 16.044 ml | 32.088 ml |
5 mM | 0.642 ml | 3.209 ml | 6.418 ml |
10 mM | 0.321 ml | 1.604 ml | 3.209 ml |
5 mM | 0.064 ml | 0.321 ml | 0.642 ml |
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