中文名 | 西那卡塞 |
英文名 | Cinacalcet |
别名 | 西纳卡塞 西那卡塞 西那卡塞盐酸 西拉卡塞杂质 甲状旁腺激素杂质 西那卡塞(晶型II) 甲状旁腺激素(西那卡塞) 西那卡塞-D3(R-对映体) N-((1R)-1-(1-萘基)乙基)-3-(3-(三氟甲基)苯基)丙-1-胺 |
英文别名 | AMG073 AMG 073 AMG-073 Sinakasse Cinacalcel CINACALCET Cinacalcet N-((1R)-1-(1-Naphthyl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine (aR)-a-Methyl-N-[3-[3-(trifluoromethyl)phenyl)propyl]-1-napthalenemethanamine (aR)-α-Methyl-N-[3-[3-(trifluoromethyl)phenyl)propyl]-1-napthalenemethanamine N-[(1R)-1-(naphthalen-1-yl)ethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine |
CAS | 226256-56-0 |
EINECS | 682-701-7 |
化学式 | C22H22F3N |
分子量 | 357.42 |
InChI | InChI=1/C22H22F3N/c1-16(20-13-5-10-18-9-2-3-12-21(18)20)26-14-6-8-17-7-4-11-19(15-17)22(23,24)25/h2-5,7,9-13,15-16,26H,6,8,14H2,1H3/t16-/m1/s1 |
密度 | 1.154±0.06 g/cm3(Predicted) |
沸点 | 440.9±45.0 °C(Predicted) |
闪点 | 220.5°C |
蒸汽压 | 5.67E-08mmHg at 25°C |
溶解度 | 氯仿 (微溶) 、甲醇 (微溶) |
折射率 | 1.563 |
酸度系数 | 9.19±0.29(Predicted) |
存储条件 | Keep in dark place,Sealed in dry,2-8°C |
外观 | 滑油 |
颜色 | Yellow |
体内研究 | Cinacalcet HCl (5 and 10 mg/kg) results in a significant reduction in parathyroid gland weight in 5/6 nephrectomy animals. In sham animals, Cinacalcet HCl has no effect on parathyroid gland cell proliferation or parathyroid weight compared with vehicle treatment. There are no differences in serum phosphorus levels in Cinacalcet HCl (10, 5, or 1 mg/kg) treated 5/6 nephrectomized animals compared with vehicle-treated 5/6 nephrectomized animals. Cinacalcet HCl treatment significantly reduces blood ionized calcium levels in sham animals. Cinacalcet (30 mg/kg/24 h) leads to a marked reduction in circulating parathyroid hormone and a modest reduction in serum Ca. Cinacalcet does not alter UCa when the GHS rats are fed the normal Ca diet but lowers UCa when they are fed the low Ca diet. Cinacalcet does not alter U supersaturation with respect to either CaOx or CaHPO4 on either diet. |
下游产品 | 西那卡塞杂质 |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.798 ml | 13.99 ml | 27.979 ml |
5 mM | 0.56 ml | 2.798 ml | 5.596 ml |
10 mM | 0.28 ml | 1.399 ml | 2.798 ml |
5 mM | 0.056 ml | 0.28 ml | 0.56 ml |
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