中文名 | lucanthone |
英文名 | lucanthone |
别名 | 硫坎酮 硫蒽酮 甲硫蒽酮 甲硫恩酮 APE-1抑制剂(LUCANTHONE) 1-((2-(二乙基氨基)乙基)氨基)-4-甲基硫杂蒽-9-酮 1-((2-(二乙氨基)乙基)氨基)-4-甲基-9H-硫杂蒽-9-酮 |
英文别名 | Lucantona lucanthone Lycanthone Lucanthonum 1-(2-diethylaminoethylamino)-4-(methyl)thioxanthen-9-one 1-[[2-(Diethylamino)ethyl]amino]-4-methyl-9H-thioxanthen-9-one 9H-Thioxanthen-9-one, 1-[[2-(diethylamino)ethyl]amino]-4-methyl- |
CAS | 479-50-5 |
EINECS | 207-532-4 |
化学式 | C20H24N2OS |
分子量 | 340.48 |
密度 | 1.0915 (rough estimate) |
熔点 | 64.5°C |
沸点 | 512.4±50.0 °C(Predicted) |
折射率 | 1.5950 (estimate) |
酸度系数 | 10.00±0.25(Predicted) |
存储条件 | 2-8℃ |
体外研究 | Lucanthone is a novel inhibitor of autophagy that induces cathepsin D-mediated apoptosis. To investigate the anticancer activity of Lucanthone, cell viability is measured by MTT assay. Lucanthone reduces cell viability to a similar extent in a panel of seven breast cancer cell lines. In addition, a direct comparison reveals that Lucanthone is significantly more potent than Chloroquine (CQ) at reducing breast cancer cell viability with a mean IC 50 of 7.2 μM versus 66 μM for CQ. Measurement of cell viability in two representative cell lines (MDA-MB-231 and BT-20) by ATPlite assay and trypan blue exclusion reveals comparable results. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.937 ml | 14.685 ml | 29.37 ml |
5 mM | 0.587 ml | 2.937 ml | 5.874 ml |
10 mM | 0.294 ml | 1.469 ml | 2.937 ml |
5 mM | 0.059 ml | 0.294 ml | 0.587 ml |
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