硫酸多粘菌素
硫酸多粘菌素(polymyxin B standard solution)
CAS: 1405-20-5
化学式: C56H100N16O17S
| 中文名 | 硫酸多粘菌素 |
| 英文名 | polymyxin B standard solution |
| 别名 | 硫酸阿罗多粘 硫酸多粘菌素 硫酸多粘菌素B 多粘菌素B硫酸酯 多粘菌素B硫酸盐 多粘菌素 B 硫酸盐 托吡卡胺硫酸多粘菌素B 硫酸多粘菌素B细胞培养级 硫酸多粘菌素 B1405-20-5 |
| 英文别名 | POLYMYXIN B Polymyxin B (PMB) POLYMYXIN B (PMB) Polymyxin B sulfate POLYMYXIN B SULFATE POLYMIXIN B SULFATE Polymyxin B Sulphate Polymyxin B solution POLYMYXIN B SULPHATE POLYMYXIN-B 2,5-SULFATE Polymyxin B 2,5-SULFATE polymyxin B sulfate usp Polymyxin B sulfate salt POLYMYXIN B SULFATE SALT polymyxin B standard solution POLYMYXIN B SULFATE, BACILLUS POLYMYXA N~2~-[4-amino-2-(formylamino)butanoyl]-N-(3-amino-1-{[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(2-hydroxyethyl)-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl]carbamoyl}propyl)homoserinamide sulfate (salt) N-[3-amino-1-[[1-[[3-amino-1-[[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-isobutyl-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]carbamoyl]propyl]carbamoyl]-2-hydroxy-propyl]carbamoyl]propyl]-6-methyl-octanamide,sulfuric acid |
| CAS | 1405-20-5 |
| EINECS | 215-774-7 |
| 化学式 | C56H100N16O17S |
| 分子量 | 1301.56 |
| InChI | InChI=1/C48H82N16O13.H2O4S/c1-27(2)24-37-47(76)59-32(11-19-52)41(70)56-31(10-18-51)43(72)61-35(14-22-65)39(68)54-21-13-34(45(74)57-33(12-20-53)44(73)64-38(48(77)63-37)25-28-6-4-3-5-7-28)60-42(71)30(9-17-50)58-46(75)36(15-23-66)62-40(69)29(8-16-49)55-26-67;1-5(2,3)4/h3-7,26-27,29-38,65-66H,8-25,49-53H2,1-2H3,(H,54,68)(H,55,67)(H,56,70)(H,57,74)(H,58,75)(H,59,76)(H,60,71)(H,61,72)(H,62,69)(H,63,77)(H,64,73);(H2,1,2,3,4) |
| 熔点 | 217-220°C (dec.) |
| 沸点 | 1611°C at 760 mmHg |
| 闪点 | 928.1°C |
| 水溶性 | Soluble in water at 50mg/ml/n |
| 蒸汽压 | 0mmHg at 25°C |
| 溶解度 | H2O: 50 mg/mL |
| 酸度系数 | pKa 8.9 (Uncertain) |
| PH值 | pH (10g/L, 25℃) : 4.5～7.0 |
| 存储条件 | 2-8°C |
| 稳定性 | 吸湿性 |
| 敏感性 | Sensitive to light |
| 外观 | 粉末 |
| 颜色 | colorless or slightly yellow |
| Merck | 14,7573 |
| MDL号 | MFCD00131991 |
| 危险品标志 | Xn - 有害物品 |
| 风险术语 | 22 - 吞食有害。 |
| 安全术语 | S22 - 切勿吸入粉尘。 S24/25 - 避免与皮肤和眼睛接触。 |
| 危险品运输编号 | 3249 |
| WGK Germany | 3 |
| RTECS | TR1150000 |
| FLUKA BRAND F CODES | 3-8-10 |
| 海关编号 | 2941 90 00 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
| 参考资料 展开查看 | 1. 周晴. 副溶血弧菌类脂A结构分析及相关基因研究[D].江南大学,2020. 2. [IF=10.588] Fangchao Yin et al."A portable digital optical kanamycin sensor developed by surface-anchored liquid crystal droplets."J Hazard Mater. 2021 Oct;420:126601 3. [IF=7.086] Juan Liu et al."Differential regulation and the underlying mechanisms of clay minerals to Escherichia coli under the stress of polymyxin B: Comparing halloysite with kaolinite."Chemosphere. 2021 Feb;265:129095 4. [IF=6.953] QingChi Wang et al."Structural characteristics and immune-enhancing activity of an extracellular polysaccharide produced by marine Halomonas sp. 2E1."Int J Biol Macromol. 2021 Jul;183:1660 5. [IF=2.281] Zhiqiang Zhang et al."Contribution of the colicin receptor CirA to biofilm formation, antibotic resistance, and pathogenicity of Salmonella Enteritidis."J Basic Microb. 2020 Jan;60(1):72-81 |
硫酸多粘菌素 - 介绍
多粘菌素系由多粘芽胞杆菌（bacilluspolymyxa）产生的一组多肽类抗生素。多粘菌素B和E供药用，常用其硫酸盐。硫酸多粘菌素B其抗菌谱及临床应用与多粘菌素E相似，对革兰阴性杆菌，如大肠杆菌、绿脓杆菌、副大肠杆菌、肺炎克雷白杆菌、嗜酸杆菌、百日咳杆菌及痢疾杆菌等有抑制或杀菌作用。
最后更新：2022-10-16 17:13:51
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