索非那新
索非那新(Solifenacin)
CAS: 242478-37-1
化学式: C23H26N2O2
| 中文名 | 索非那新 |
| 英文名 | Solifenacin |
| 别名 | 索非那新 索利那新-D5 索非那新及其中间体 4R-羟基索利那新 4R-羟基SOLIFENACIN N-氧化物 1-氮杂双环[2.2.2]辛烷-8-基-(1S)-1-苯基-3,4-二氢-1H-异喹啉-2-甲酸酯 (8R)-1-氮杂双环(2.2.2)辛烷-8-基-(1S)-1-苯基-3,4-二氢-1H-异喹啉-2-甲酸酯 (8R)-1-氮杂双环(2.2.2)辛烷-8-基-(1S)-1-苯基-3,4-二氢-1H-异喹啉-2-甲酸酯 (索非那新) (R)-(S)-奎宁环素-3-基-1-苯基-3,4-二氢异喹啉-2(1H)-羧酸盐(索利那新杂质) |
| 英文别名 | YM 905 Solif·Nacin Solifenacin Unii-A8910sqj1u 4R-Hydroxy Solifenacin Solifenacin intermediate 4R-Hydroxy Solifenacin N-Oxide (1S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylate (3R)-1-azabicyclo[2.2.2]oct-3-yl (1S)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate [(8R)-1-azabicyclo[2.2.2]octan-8-yl] (1S)-1-phenyl-3,4-dihydro-1H-isoquinoline-2-carboxylate 3,4-dihydro-1-phenyl-(1S)-2(1H)-Isoquinolinecarboxylic acid (3R)-1-azabicyclo[2.2.2]oct-3-yl ester 2(1H)-Isoquinolinecarboxylicacid, 3,4-dihydro-1-phenyl-, (3R)-1-azabicyclo[2.2.2]oct-3-yl ester, (1S)- |
| CAS | 242478-37-1 |
| 化学式 | C23H26N2O2 |
| 分子量 | 362.47 |
| InChI | InChI=1/C23H26N2O2/c26-23(27-21-16-24-13-10-18(21)11-14-24)25-15-12-17-6-4-5-9-20(17)22(25)19-7-2-1-3-8-19/h1-9,18,21-22H,10-16H2/t21-,22-/m0/s1 |
| 密度 | 1.24±0.1 g/cm3(Predicted) |
| 沸点 | 505.5±50.0 °C(Predicted) |
| 闪点 | 259.5°C |
| 蒸汽压 | 2.41E-10mmHg at 25°C |
| 折射率 | 1.648 |
| 酸度系数 | 9.03±0.33(Predicted) |
| 存储条件 | 2-8℃ |
| 体外研究 | Solifenacin is a novel muscarinic receptor antagonist with pK i s of 7.6±0.056, 6.9±0.034 and 8.0±0.021 for M1, M2 and M3 receptors, respectively. In murine submandibular gland cells, the antagonistic effects of 100 nM Solifenacin and oxybutynin on Ca 2+ mobilization evoked by varying doses of carbachol (CCh) are examined. Solifenacin does not shift the CCh dose-activation curve in a parallel manner whereas oxybutynin shows insurmountable antagonism. The pK b values are obtained as 7.4±0.17 for Solifenacin and 8.8±0.21 for oxybutynin. |
| 体内研究 | Solifenacin reduces bladder responses by 40% at a dose of 210 nmol/kg (0.1 mg/kg) and abolishes them at 2100 nmol/kg (1 mg/kg). In contrast, its inhibitory effects on salivary and cardiac responses are only slight at 630 nmol/kg (0.3 mg/kg), and reach 66% and 49%, respectively, at 2100 nmol/kg (1 mg/kg). At doses of 63 and 210 nmol/kg (0.03 and 0.1 mg/kg), Solifenacin slightly increases saliva secretion. Solifenacin (0.01 to 0.3 mg/kg i.v.) dose-dependently increases bladder capacity and voided volume at doses of 0.03 mg/kg i.v. or more, but does not affect residual volume or micturition pressure at any dose tested. |
| 下游产品 | 索利那新N-氧化物 |
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产品名: (S)-(R)-氮杂双环(2.2.2)辛烷-8-基-1-苯基-3,4-二氢-1H-异喹啉-2-甲酸酯 去供应商网站查看 询盘CAS: 242478-37-1
产地: 北京
包装: 瓶
规格: YS105852-5g,YS105852-1g,YS105852-25g
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库存: 一周左右
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QQ: 3193328036
微信: 17801761073
产品描述: 索莱宝直销，欢迎来询
提供多种规格现货供应
产品名: (S)-(R)-氮杂双环(2.2.2)辛烷-8-基-1-苯基-3,4-二氢-1H-异喹啉-2-甲酸酯 去供应商网站查看 询盘CAS: 242478-37-1
产地: 北京
包装: 瓶
规格: YS105852-5g,YS105852-1g,YS105852-25g
价格: 电话、微信、QQ、邮件
库存: 一周左右
电话: 010-50973130
手机: 17801761073(微信同号)
电子邮件: 3193328036@qq.com
QQ: 3193328036
微信: 17801761073
产品描述: 索莱宝直销，欢迎来询
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