羟甲硫蒽酮_化工百科

中文名	海恩酮
英文名	hycanthone
别名	海恩酮羟甲硫蒽酮 1-((2-(二乙基氨基)乙基)氨基)-4-(羟甲基)-9H-噻吨-9-酮
英文别名	ETRENOL Win 249-33 hycanthone Etrenol(mesylate) 1-(2-diethylaminoethylamino)-4-methylol-thioxanthen-9-one 1-((2-(diethylamino)ethyl)amino)-4-(hydroxymethyl)thioxanthen-9-one 1-((2-(diethylamino)ethyl)amino)-4-(hydroxymethyl)-9h-thioxanthen-9-on 1-{[2-(diethylamino)ethyl]amino}-4-(hydroxymethyl)-9H-thioxanthen-9-one 1-[(2-[DIETHYLAMINO]ETHYL)AMINO]-4-[HYDROXYMETHYL]-9H-THIOXANTHEN-9-ONE 9H-Thioxanthen-9-one, 1-[[2-(diethylaMino)ethyl]aMino]-4-(hydroxyMethyl)-
CAS	3105-97-3
EINECS	221-463-7
化学式	C20H24N2O2S
分子量	356.48
InChI	InChI=1/C20H24N2O2S/c1-3-22(4-2)12-11-21-16-10-9-14(13-23)20-18(16)19(24)15-7-5-6-8-17(15)25-20/h5-10,21,23H,3-4,11-13H2,1-2H3
密度	1.1269 (rough estimate)
熔点	100.6-102.8°
沸点	570.5±50.0 °C(Predicted)
闪点	298.9°C
蒸汽压	7.42E-14mmHg at 25°C
折射率	1.6000 (estimate)
酸度系数	pKa 3.40 (Uncertain)
存储条件	Keep in dark place,Sealed in dry,2-8°C
体外研究	Hycanthone has an IC 50 of 80 nM for inhibition of APE1 incision of depurinated plasmid DNA. Hycanthone (0.05-100 µM; for 2 h) promotes APE1 cleavage in presence of Cycloheximide (CHX) and this cleavage is inhibited by 1% DMSO. Hycanthone at 20 mg/mL or more is progressively more detrimental to cell viability. Results reveal that increased concentrations of Hycanthone, ranging from 0.1 to 10 μg/mL, progressively reduces viral interferon yields as much as 73% compare to that of controls.
体内研究	Results show that the incorporation of tritiated thymidine into TCA-precipitable material of adult sensitive worms undergo a progressive decrease after treatment with Hycanthone. Immature worms are totally unaffected by Hycanthone at all times tested. Male worms treated with Hycanthone show signs of a possible partial recovery from the initial low levels of incorporation. The incorporation of tritiated leucine by drug-sensitive worms treated with Hycanthone is inhibited by 40 to 50% in the first four days after treatment. Results show that, 7 days after Hycanthone treatment, both ribosomal RNA species are reduced by at least 80% with respect to untreated worms, with some indication of a possible accumulation of heavier precursor molecules.
危险品标志	T - 有毒物品
风险术语	R45 - 可能致癌。 R46 - 可能引起遗传性基因损害。 R20/21/22 - 吸入、皮肤接触及吞食有害。
安全术语	S53 - 避免接触，使用前须获得特别指示说明。 S36/37/39 - 穿戴适当的防护服、手套和护目镜或面具。 S45 - 若发生事故或感不适，立即就医(可能的话，出示其标签)。
WGK Germany	3
RTECS	XO1590000

羟甲硫蒽酮 - 配置溶液浓度参考

	1mg	5mg	10mg
1 mM	2.805 ml	14.026 ml	28.052 ml
5 mM	0.561 ml	2.805 ml	5.61 ml
10 mM	0.281 ml	1.403 ml	2.805 ml
5 mM	0.056 ml	0.281 ml	0.561 ml

最后更新：2024-01-02 23:10:35

羟甲硫蒽酮 - 简介

海恩酮（又称为4-羟基-4-甲基戊酮或HMK）是一种有机化合物。

海恩酮是一种无色到浅黄色间的油状液体，具有类似溶于水的水溶液、醇和醚的溶解性。它在空气中不稳定，在高温下可能会分解。
其次，海恩酮在制造尼古丁酸胺、梯巴韦林和多种递质的前体中起到重要作用。

制备海恩酮的常见方法是通过甲基戊醇和乙醛的硫酸催化缩合反应。具体步骤为：将甲基戊醇和乙醛在硫酸存在下加热反应，生成海恩酮。

海恩酮的安全信息：它有轻微的刺激性和伴随的可燃性。避免与皮肤和眼睛接触，并远离火源和明火。如意外接触或摄入，应立即就医。

最后更新：2024-04-09 21:54:55

北京索莱宝科技有限公司

提供多种规格现货供应

产品名: 1-((2-(二乙基氨基)乙基)氨基)-4-(羟甲基)-9H-噻吨-9-酮去供应商网站查看询盘
CAS: 3105-97-3
产地: 北京
包装: 瓶
规格: YS108348-25mg,YS108348-250mg,YS108348-50mg,YS108348-100mg,YS108348-1g
价格: 电话、微信、QQ、邮件
库存: 一周左右
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上海吉至生化科技有限公司

现货供应

产品名: 1-((2-(二乙基氨基)乙基)氨基)-4-(羟甲基)-9H-噻吨-9-酮去供应商网站查看询盘
CAS: 3105-97-3
产地: 中国上海
包装: 1g
规格: 95%
价格: 8890.00
库存: 现货
电话: 400-900-4166
手机: 18017137653
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产品描述: 中文名：1-((2-(二乙基氨基)乙基)氨基)-4-(羟甲基)-9H-噻吨-9-酮英文名:1-((2-(Diethylamino)ethyl)amino)-4 更多

上海麦克林生化科技股份有限公司

现货供应

产品名: Hycanthone 去供应商网站查看询盘
CAS: 3105-97-3
产地: 上海
规格: H879668
价格: 10mg-396
库存: 7天内发货
电话: 13816333479/17821173903
手机: 13816333479/17821173903
电子邮件: wangrui@macklin.cn
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