中文名 | 老鼠胰脏多肽 |
英文名 | Pancreatic Polypeptide rat |
别名 | 胰脏多肽 老鼠胰脏多肽 神经肽(NPY)受体激动剂 |
英文别名 | PP, RAT Pancreatic Polypeptide rat Rat pancreatic polypeptide PANCREATIC POLYPEPTIDE, RAT APLEPMYPGDYATHEQRAQYETQLRRYINTLTRPRY-NH2 ALA-PRO-LEU-GLU-PRO-MET-TYR-PRO-GLY-ASP-TYR-ALA-THR-HIS-GLU-GLN-ARG-ALA-GLN-TYR ALA-PRO-LEU-GLU-PRO-MET-TYR-PRO-GLY-ASP-TYR-ALA-THR-HIS-GLU-GLN-ARG-ALA-GLN-TYR-GLU-THR-GLN-LEU-ARG-ARG-TYR-ILE-ASN-THR-LEU-THR-ARG-PRO-ARG-TYR-NH2 H-ALA-PRO-LEU-GLU-PRO-MET-TYR-PRO-GLY-ASP-TYR-ALA-THR-HIS-GLU-GLN-ARG-ALA-GLN-TYR-GLU-THR-GLN-LEU-ARG-ARG-TYR-ILE-ASN-THR-LEU-THR-ARG-PRO-ARG-TYR-NH2 |
CAS | 90419-12-8 |
化学式 | C195H298N58O57S1 |
分子量 | 4398.87 |
存储条件 | −20°C |
MDL号 | MFCD00081813 |
体外研究 | Pancreatic Polypeptide, rat is an agonist of NPY receptor, with high affinity at NPYR4. Pancreatic Polypeptide (1 μM) does not alter proliferation in BRIN BD11 or 1.1B4 beta-cells, but reverses the decreased cell viability in BRIN BD11 cells induced by streptozotocin. Pancreatic Polypeptide (0.1 nM-1 μM) shows no effect on insulin secretion from isolated mouse islets, and does not affect the membrane potential and (Ca 2+ ) i levels in BRIN BD11 cells at 1 μM. |
体内研究 | Pancreatic Polypeptide (25 nmol/kg bw, i.p.) reduces glucose-stimulated insulin concentrations but shows no effect on acute feeding behaviour in overnight fasted mice. |
WGK Germany | 3 |
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