葫芦素E
葫芦素 E(2,16α,20,25-tetrahydroxy-9β-methyl-10α,-19-norlanosta-1,5,23(E)-triene-3,11,22-trione 25-acetate)
CAS: 18444-66-1
化学式: C32H44O8
| 中文名 | 葫芦素 E |
| 英文名 | 2,16α,20,25-tetrahydroxy-9β-methyl-10α,-19-norlanosta-1,5,23(E)-triene-3,11,22-trione 25-acetate |
| 别名 | 葫芦素E 葫芦苦素E 葫芦素 E 葫芦苦素 E 葫芦素E对照品 葫芦素E(标准品) 葫芦素E(葫芦苦素E) 葫芦素 E, 来源于甜瓜 |
| 英文别名 | A-ELATERIN 25-acetate 18444-66-1 Cucurbitacin E cucurbitacin E ALPHA-ELATERIN CUCURBITACIN E alpha-elaterine cucurbitacine-e CUCURBITACIN E(SH) 19-nor-9-beta,10-alpha-lanosta-1,5,23-triene-3,11,22-trione,2,16-alpha,20,25-t 2,16α,20,25-tetrahydroxy-9β-methyl-10α,-19-norlanosta-1,5,23(E)-triene-3,11,22-trione 25-acetate 2,16,20-trihydroxy-9,10,14-trimethyl-1,11,22-trioxo-4,9-cyclo-9,10-secocholesta-2,5,23-trien-25-yl acetate (23E)-2,16,20-trihydroxy-9,10,14-trimethyl-1,11,22-trioxo-4,9-cyclo-9,10-secocholesta-2,5,23-trien-25-yl acetate (4R,9beta,16alpha,23E)-2,16,20-trihydroxy-9,10,14-trimethyl-1,11,22-trioxo-4,9-cyclo-9,10-secocholesta-2,5,23-trien-25-yl acetate [(E)-5-[(8S,9R,10R,13R,14S,16R,17R)-2,16-dihydroxy-4,4,9,13,14-pentamethyl-3,11-dioxo-8,10,12,15,16,17-hexahydro-7H-cyclopenta[a]phenanthren-17-yl]-5-hydroxy-1,1-dimethyl-4-oxo-hex-2-enyl] acetate |
| CAS | 18444-66-1 |
| EINECS | 242-325-2 |
| 化学式 | C32H44O8 |
| 分子量 | 556.69 |
| InChI | InChI=1/C32H44O8/c1-17(33)40-27(2,3)13-12-23(36)32(9,39)25-21(35)15-29(6)22-11-10-18-19(14-20(34)26(38)28(18,4)5)31(22,8)24(37)16-30(25,29)7/h10,12-14,19,21-22,25,34-35,39H,11,15-16H2,1-9H3/b13-12+/t19-,21-,22+,25+,29+,30-,31+,32?/m1/s1 |
| InChIKey | NDYMQXYDSVBNLL-MUYMLXPFSA-N |
| 密度 | 1.1059 (rough estimate) |
| 熔点 | 228-234°C |
| 沸点 | 545.56°C (rough estimate) |
| 比旋光度 | D -59° (c = 0.7 in chloroform) |
| 闪点 | 224.4°C |
| 蒸汽压 | 1.84E-23mmHg at 25°C |
| 溶解度 | DMSO: 可溶15mg/mL，澄清 |
| 折射率 | 1.4900 (estimate) |
| 酸度系数 | 8.51±0.70(Predicted) |
| 存储条件 | -20°C |
| 外观 | 粉末 |
| 颜色 | white to beige |
| 物化性质 | 白色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于甜瓜蒂。 |
| MDL号 | MFCD00135936 |
| 体外研究 | To explore the antitumor activity of Cucurbitacin E (CuE) against colorectal cancer (CRC) cells, an in vitro study is initiated in which each of the CRC cell lines is exposed to increasing doses of Cucurbitacin E (0, 2.5, 5, and 7.5 μM) over a period of 24 h. The proliferation of the Cucurbitacin E-treated cancer cells is then measured using the MTT method. Cucurbitacin E is shown to induce morphological changes in the primary colon cancer cells. Microscopic observation showed that following exposure to Cucurbitacin E (5 μM) between 6 and 24 h, the primary colon cancer cells underwent a remarkable change in morphology. Cucurbitacin E inhibits tumor growth by arresting the cell cycle in the G 2 /M phase via GADD45γ gene expression and the blockage of cyclin B1/CDC2 complex in primary CRC cells. |
| 体内研究 | A high fat diet mice model of metabolic syndrome (HFD-MetS) is developed to assess the role of Cucurbitacin E (CuE) on body weight and fat tissue biology. Significant decrease in body weights of HFD-MetS mice treated with Cucurbitacin E (0.5mg/kg) are found as compared to HFD-MetS mice treated with vehicle alone. Cucurbitacin E treatment reduces all fat pads weights in HFD-MetS mice. 55% reduction is observed in total fat in mice, after treatment with Cucurbitacin E in comparison to HFD-MetS mice. Abdominal obesity is strongly associated with metabolic syndrome. Central obesity is reduced to 50% after Cucurbitacin E treatment as compared to HFD MetS mice, elucidating the effectiveness of Cucurbitacin E in targeting MetS. |
| 危险品标志 | Xn - 有害物品 |
| 风险术语 | R25 - 吞食有毒。 R22 - 吞食有害。 |
| 安全术语 | S1 - 上锁保存。 S22 - 切勿吸入粉尘。 S45 - 若发生事故或感不适，立即就医(可能的话，出示其标签)。 S24/25 - 避免与皮肤和眼睛接触。 |
| 危险品运输编号 | 3172 |
| WGK Germany | 3 |
| RTECS | RC6305500 |
| 海关编号 | 29153900 |
| 参考资料 展开查看 | 1. 张雅男 高明洁 祝文博 等. HPLC-UV法同时测定葫芦素片中葫芦素B和葫芦素E的含量[J]. 化学工程师 2018. 2. 张晓倩, 田丽萍, 张义晖,等. 籽瓜提取物葫芦素E对化学性肝损伤的保护作用研究[J]. 食品研究与开发, 2018, v.39；No.341(16):172-177. 3. 沈杭, 陈宗科, 钱叶本. 葫芦素E诱导肝癌细胞凋亡及其机制[J]. 临床与实验病理学杂志, 2015, 31(12):23-27. 4. 徐放, 王艳杰, 孙阳,等. 钴60-γ射线辐射对天花粉有效成分的影响[J]. 中国药师, 2019, 22(02):355-358. 5. [IF=3.205] Zhibin Wang et al."Simultaneous determination of cucurbitacin B and cucurbitacin E in rat plasma by UHPLC-MS/MS: A pharmacokinetics study after oral administration of cucurbitacin tablets."J Chromatogr B. 2017 Oct;1065-1066:63 6. [IF=2.014] Si-Yuan JING et al."In vitro antitumor effect of cucurbitacin E on human lung cancer cell line and its molecular mechanism."Chin J Nat Medicines. 2020 Jul;18:483 |
葫芦素E - 简介
葫芦素E（Curcumin）是一种从姜黄中提取的化合物，具有强烈的黄色颜色。它是一种非营养性物质，具有抗氧化、抗炎、抗菌和抗肿瘤等多种生物活性。
葫芦素E的制法一般采用溶剂提取法。将姜黄粉末用合适的溶剂（如乙醇或醚类溶剂）浸泡，经过过滤和浓缩，最后得到葫芦素E的浓缩提取物。
葫芦素E的安全信息：它被认为在一般剂量下是相对安全的。高剂量的葫芦素E可能对身体产生毒性作用，例如干扰消化道功能或引起肝毒性。某些人可能对姜黄过敏，对花粉过敏的人也可能对葫芦素E敏感。如有过敏症状或不适，应立即停止使用并向医生咨询。
葫芦素E的制法一般采用溶剂提取法。将姜黄粉末用合适的溶剂（如乙醇或醚类溶剂）浸泡，经过过滤和浓缩，最后得到葫芦素E的浓缩提取物。
葫芦素E的安全信息：它被认为在一般剂量下是相对安全的。高剂量的葫芦素E可能对身体产生毒性作用，例如干扰消化道功能或引起肝毒性。某些人可能对姜黄过敏，对花粉过敏的人也可能对葫芦素E敏感。如有过敏症状或不适，应立即停止使用并向医生咨询。
最后更新：2024-04-09 21:54:55
供应商列表
现货供应
产品名: Cucurbitacin E 去供应商网站查看 询盘CAS: 18444-66-1
产地: 中国-STD
包装: 支
规格: 10mg，25mg，50mg，100mg
价格: 电询
库存: 现货
电话: 0714-3999186
手机: 15671228036
电子邮件: 2853786052@qq.com
QQ: 2853786052
微信: 15671228036
产品描述: AN219575
现货供应
产品名: Cucurbitacin E 去供应商网站查看 询盘CAS: 18444-66-1
产地: 中国-STD
包装: 支
规格: 10mg，25mg，50mg，100mg
价格: 电询
库存: 现货
电话: 0714-3999186
手机: 15671228036
电子邮件: 2853786052@qq.com
QQ: 2853786052
微信: 15671228036
产品描述: AN219575
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