中文名 | SER-LEU-ILE-GLY-ARG-LEU-NH2 |
英文名 | H-SER-LEU-ILE-GLY-ARG-LEU-NH2 |
别名 | 蛋白酶激活的受体-2激活肽 激动剂肽-PAR-2 (1-6) AMIDE (MOUSE, RAT) |
英文别名 | H2N-SLIGRL-AMIDE PAR2-AP, SLIGRL-NH2 SER-LEU-ILE-GLY-ARG-LEU-NH2 Ser-Leu-Ile-Gly-Arg-Leu-NH2 H-SER-LEU-ILE-GLY-ARG-LEU-NH2 Ser-Leu-Ile-Gly-Arg-Leu-amide trifluoroacetate salt SLIGRL-NH2 Protease-Activated Receptor 2 (PAR2) Agonist COAGULATION FACTOR II RECEPTOR-LIKE 1 (1-6) AMIDE (MOUSE, RAT) ThroMbin Receptor-Like 1 (1-6) aMide (Mouse, rat), SLIGRLaMide, Proteinase Activated Receptor 2 (1-6) aMide (Mouse, rat), Coagulation Factor II Receptor-Like 1 (1-6) aMide (Mouse, rat) |
CAS | 171436-38-7 |
化学式 | C29H56N10O7 |
分子量 | 656.82 |
密度 | 1.34±0.1 g/cm3(Predicted) |
酸度系数 | 12.04±0.10(Predicted) |
存储条件 | -20°C |
外观 | 固体 |
体外研究 | SLIGRL-NH2 is an agonist of PAR-2 and MrgprC11. SLIGRL-NH2 causes an L-NAME-inhibited relaxation. Based on SLIGRL-NH 2 causing a concentration-dependent relaxation with an EC 50 of 10 µM in endothelium-free preparations in the presence of perivascular adipose tissue (PVAT) , 20 µM is used as a suitable ‘test’ concentration of peptide in subsequent experiments designed to evaluate the effects of potential inhibitors of ADRF release/action. In the endothelium-free aorta preparations, SLIGRL-NH2 causes a concentration-dependent relaxation in preparations only in the presence of PVAT [+PVAT, -ENDO (endothelium)]. |
安全术语 | S22 - 切勿吸入粉尘。 S24/25 - 避免与皮肤和眼睛接触。 |
WGK Germany | 3 |
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