血管紧张素II
血管紧张素II(angiotensin II)
CAS: 4474-91-3
化学式: C50H71N13O12
| 中文名 | 血管紧张素II |
| 英文名 | angiotensin II |
| 别名 | 增加压素 血管紧张素2 血管紧张素II 血管紧张肽酰胺 血管紧张肽II 血管紧张素II(人) 血管紧张素 II乙酸盐 增血压素,HYPERTENSIN ANGIOTENSIN II 血管紧张素Ⅱ 血管紧张素II|ANGIOTENSIN II|ANGIOTENSIN II,HUMAN |
| 英文别名 | DRVYIHPF angiotensin II [ILE5]-ANGIOTENSIN 2 Angiotensin Ii, Human ANGIOTENSIN II, HUMAN HYPERTENSION II HUMAN L-ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE H-ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-OH ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-OH 2CH3CHOOH H2O FLUORESCEIN-NHCS-NH-ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-OH |
| CAS | 4474-91-3 |
| EINECS | 2017-001-1 |
| 化学式 | C50H71N13O12 |
| 分子量 | 1046.2 |
| InChI | InChI=1/C50H71N13O12/c1-5-28(4)41(47(72)59-36(23-31-25-54-26-56-31)48(73)63-20-10-14-38(63)45(70)60-37(49(74)75)22-29-11-7-6-8-12-29)62-44(69)35(21-30-15-17-32(64)18-16-30)58-46(71)40(27(2)3)61-43(68)34(13-9-19-55-50(52)53)57-42(67)33(51)24-39(65)66/h6-8,11-12,15-18,25-28,33-38,40-41,64H,5,9-10,13-14,19-24,51H2,1-4H3,(H,54,56)(H,57,67)(H,58,71)(H,59,72)(H,60,70)(H,61,68)(H,62,69)(H,65,66)(H,74,75)(H4,52,53,55)/t28-,33-,34-,35-,36-,37-,38-,40-,41-/m0/s1 |
| InChIKey | CZGUSIXMZVURDU-JZXHSEFVSA-N |
| 密度 | 1.1257 (rough estimate) |
| 沸点 | 809.08°C (rough estimate) |
| 水溶性 | Soluble in Water (25 mg/ml), and 5% Acetic Acid (1 mg/ml). |
| 溶解度 | 溶于水 (25 mg/ml)，和5% 乙酸 (1 mg/ml)。 |
| 折射率 | 1.6700 (estimate) |
| 酸度系数 | pK1: 10.37 (25°C) |
| 存储条件 | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| 敏感性 | Thermal sensitivity |
| 外观 | 粉末 |
| 颜色 | orange |
| 物化性质 | 白色冷冻干燥粉末；易溶于水，溶于甲醇、乙醇和丙二醇，不溶于乙醚和氯仿；水溶液中pH值为5-8；在中性溶液中稳定，遇强酸、强碱时易水解；氨基酸顺序为：天冬氨酰、精氨酰、缬氨酰、酪氨酰、异白氨酰、组氨酰、脯氨酰、苯丙氨酸。 |
| 体外研究 | Most of the known actions of Angiotensin II (Ang II) are mediated by AT 1 receptors, the AT 2 receptor contributes to the regulation of blood pressure and renal function. Angiotensin II raises blood pressure (BP) by a number of actions, the most important ones being vasoconstriction, sympathetic nervous stimulation, increased aldosterone biosynthesis and renal actions. Other Angiotensin II actions include induction of growth, cell migration, and mitosis of vascular smooth muscle cells, increased synthesis of collagen type I and III in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. These actions are mediated by type 1 Ang II receptors (AT 1 ). At the cellular level, responsiveness to Angiotensin II is conferred by the expression of the two classes of angiotensin receptors (AT 1 and AT 2 ). The effects of Angiotensin II to increase blood pressure are mediated by AT1 receptors. |
| 体内研究 | To distinguish the AT 1 receptor population that is critical for the pathogenesis of hypertension, osmotic minipumps are implanted s.c. into each animal to infuse Angiotensin II (1,000 ng/kg/min) continuously for 4 weeks. Angiotensin II causes hypertension by activating AT 1 receptors in the kidney promoting sodium reabsorption. |
| WGK Germany | 3 |
| RTECS | BW2165000 |
| 上游原料 | 碳酸氢钠 N,N'-二环己基碳二亚胺 L-组氨酸 苯丙氨酯 Boc-L-天冬氨酸 4-环己酯 N-Fmoc-N'-三苯甲基-L-组氨酸 L-组氨酰-L-亮氨酸 人血管紧张素 I N-叔丁氧羰基-O-(2-溴苄氧羰基)-L-酪氨酸 |
| 参考资料 展开查看 | 1. 郑伟 常虎林 海军 宋晓雪 杜立学.Ang Ⅱ通过激活Notch1/Sox2通路对肝星状细胞LX2的活化和增殖的作用[J].中华细胞与干细胞杂志(电子版) 2018 8(03):156-160. 2. 阮旭 杨晔 徐仲儒 等. 丹参注射液对AngⅡ诱导NRK-52E细胞损伤的保护作用[J]. 中成药 2018 040(005):1170-1173. 3. 刘晓瑜,程赛博,徐煜凌,何培坤,顾民华,周凤华,贾钰华.基于ACE2-Ang(1-7)-Mas轴探讨定心方三号方改善人脐静脉内皮细胞功能的机制研究[J].中药新药与临床药理,2019,30(03):301-307. 4. 匡聪, 贾俊强, 吴琼英,等. 超声-离子液体处理对乳清蛋白酶解动力学及其产物抗氧化活性的影响[J]. 食品科学, 2017(23):32-38. 5. 聂佩,孟凡静,张金国,尉希清.黄芪甲苷抑制血管紧张素Ⅱ诱导的心肌H9c2细胞凋亡[J].中国病理生理杂志,2019,35(11):1942-1950. 6. Nie, Pei, et al. "Astragaloside IV exerts a myocardial protective effect against cardiac hypertrophy in rats, partially via activating the Nrf2/HO-1 signaling pathway." Oxidative medicine and cellular longevity 2019 (2019).https://doi.org/10.1155/2019/4625 7. [IF=4.868] Nie Pei et al."Astragaloside IV Exerts a Myocardial Protective Effect against Cardiac Hypertrophy in Rats, Partially via Activating the Nrf2/HO-1 Signaling Pathway."Oxid Med Cell Longev. 2019;2019:4625912 8. [IF=3.943] Kaiyong Yang et al."Angiotensin II contributes to intratumoral immunosuppression via induction of PD-L1 expression in non-small cell lung carcinoma."Int Immunopharmacol. 2020 Jul;84:106507 9. [IF=2.629] Mo Jiajia et al."Liquiritin Attenuates Angiotensin II-Induced Cardiomyocyte Hypertrophy via ATE1/TAK1-JNK1/2 Pathway."Evid-Based Compl Alt. 2022;2022:7861338 |
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产品名: 血管紧张素II/三氟乙酸盐 去供应商网站查看 询盘CAS: 4474-91-3
产地: 北京
包装: 瓶
规格: A9290-10mg,10mg,SA5820-10mg,10mg,IA0380-W-1ml,10mM*1ml( in Water),IA0380-10mg,10mg,IA0380-50mg,50mg
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库存: 现询
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现货供应
产品名: 血管紧张素II/三氟乙酸盐 去供应商网站查看 询盘CAS: 4474-91-3
产地: 北京
包装: 瓶
规格: A9290-10mg,10mg,SA5820-10mg,10mg,IA0380-W-1ml,10mM*1ml( in Water),IA0380-10mg,10mg,IA0380-50mg,50mg
价格: 电话、微信、QQ、邮件
库存: 现询
电话: 010-50973130
手机: 17801761073(微信同号)
电子邮件: 3193328036@qq.com
QQ: 3193328036
微信: 17801761073
产品描述: 索莱宝直销，欢迎来询
血管紧张素II的上游原料
一水柠檬酸 叔丁酯 辛酰肼 N-叔丁氧羰基-N(咪唑)-(4-甲基苯磺酰基)-L-组氨酸 N-Fmoc-N'-三苯甲基-L-组氨酸 N-BOC-1-(P-甲苯磺酰基)-L-组氨酸 二环己基铵盐 Boc-L-缬氨酸 L-组氨酰-L-亮氨酸 N-叔丁氧羰基-O-(2-溴苄氧羰基)-L-酪氨酸
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