黄羽扇豆魏特酮

中文名	Lupiwighteone
英文名	Lupiwighteone
别名	黄羽扇豆魏特酮
英文别名	Lupiwighteone 8-PRENYLGENISTEIN 8-Isopentenylgenistein 4',5,7-Trihydroxy-8-prenylisoflavone 4',5,7-Trihydroxy-8-isopentenylisoflavone 5,7-Dihydroxy-3-(4-hydroxyphenyl)-8-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one 3-(4-Hydroxyphenyl)-5,7-dihydroxy-8-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one 4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(4-hydroxyphenyl)-8-(3-methyl-2-buten-1-yl)-
CAS	104691-86-3
化学式	C20H18O5
分子量	338.35
熔点	133-135℃
存储条件	2-8℃
外观	粉末
MDL号	MFCD06796683
体外研究	Lupiwighteone (2-100 μM; 72 hours) shows cytotoxicity towards various cell lines, especially on DU-145 cells and SGC-7901 cells with IC 50 s of 23.7 μM and 21 μM, respectively. Lupiwighteone (20-60 μM; 48 hours) induces (cell cycle arrest in DU-145 cells. Lupiwighteone (20-60 μM; 48 hours) induces cells apoptosis. Lupiwighteone (20-60 μM; 48 hours) decreases the cell cycle-related protein expressions in a dose-dependent manner in DU-145 cells. Lupiwighteone (20-60 μM; 48 hours) induces a dose-dependent increase in ROS production. Lupiwighteone up-regulates of cytochrome c and caspase-3, and subsequent cleavage of PARP-1 and down-regulates of the p-Akt/Akt ratio and VEGF expression, suggests the activation of mitochondria-based intrinsic apoptosis in DU-145 cells. Cell Viability Assay Cell Line: DU-145 cells, C4-2 cells, SGC-7901 cells, Hela cells, HUVEC, MCF-7 cells, CNE cells, Vero Concentration: 2 μM, 5 μM, 25 μM, 50 μM, 100 μM Incubation Time: 72 hours Result: Had inhibition on the survival of many cancer cell lines and HUVEC. Cell Cycle Analysis Cell Line: DU-145 cells Concentration: 20 μM, 40 μM, 60 μM Incubation Time: 48 hours Result: Induced cell cycle arrest. Apoptosis Analysis Cell Line: DU-145 cells Concentration: 20 μM, 40 μM, 60 μM Incubation Time: 48 hours Result: Induced apoptosis. Western Blot Analysis Cell Line: DU-145 cells Concentration: 20 μM, 40 μM, 60 μM Incubation Time: 48 hours Result: Decreased CDK1, 2, 4, 6, cyclinD1, and cyclinB1 protein expression in a dose-dependent manner.

湖北扬信医药科技有限公司

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产品名: Lupiwighteone 去供应商网站查看询盘
CAS: 104691-86-3
产地: 中国-STD
包装: 支
规格: 10mg，25mg，50mg，100mg
价格: 电询
库存: 现货
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北京索莱宝科技有限公司

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产品名: Lupiwighteone 去供应商网站查看询盘
CAS: 104691-86-3
产地: 北京
包装: 1mg(瓶)
规格: IL4420-1mg
价格: 电话、微信、QQ、邮件
库存: 现询
电话: 010-50973130
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上海吉至生化科技有限公司

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产品名: Lupiwighteone 去供应商网站查看询盘
CAS: 104691-86-3
产地: 中国上海
包装: 5mg
规格: 分析对照品,HPLC≥95%
价格: 4800.00
库存: 现货
电话: 400-900-4166
手机: 18017137653
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产品描述: 中文名：Lupiwighteone 英文名:Lupiwighteone CAS:104691-86-3 规格:分析对照品,HPLC≥95% 产地:中国上海

上海源叶生物科技有限公司

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产品名: Lupiwighteone 去供应商网站查看询盘
CAS: 104691-86-3
产地: 上海
规格: HPLC≥95%
价格: 5mg 2700
库存: 现货
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