中文名 | 盐酸大观霉素五水合物 |
英文名 | Spectinomycin dihydrochloride pentahydrate |
别名 | 盐酸大观霉素,五水 壮观霉素(标准品) 盐酸大观霉素五水合物 大观霉素盐酸盐水合物 盐酸壮观霉素五水合物 壮观霉素盐酸盐水合物 壮观霉素,盐酸大观霉素 盐酸壮观霉素(大观霉素) 壮观霉素 二盐酸盐 五水合物 |
英文别名 | M 141 Spectam Trobicin U-18409AE Spectogard U 18,400AE UNII-HWT06H303Z SPECTINOMYCIN HCL SPECTINOMYCIN 2HCL SPECTINOMYCIN HYDROCHLORIDE Togamycin dihydrochloride pentahydrate Spectinomycin dihydrochloride pentahydrate SPECTINOMYCIN PENTAHYDRATE DIHYDROCHLORIDE SPECTINOMYCIN DIHYDROCHLORIDE PENTAHYDRATE Spectinomycin, dihydrochloride, pentahydrate Espectinomicina dihydrochloride pentahydrate Actinospectacin dihydrochloride pentahydrate SPECTINOMYCIN, DIHYDROCHLORIDE, PENTAHYDRATE, STREPTOMYCES SPECIES Decahydro-4a,7,9-trihydroxy-2-methyl-6,8-bis(methylamino)-4H-pyrano(2,3-b)(1,4)benzodioxin-4-one dihydrochloride pentahydrate 4H-Pyrano(2,3-b)(1,4)benzodioxin-4-one, decahydro-4a,7,9-trihydroxy-2-methyl-6,8-bis(methylamino)-, dihydrochloride, pentahydrate (2R,4aR,5aR,6S,7S,8R,9S,9aR,10aS)-4a,7,9-trihydroxy-2-methyl-6,8-bis(methylamino)decahydro-4H-pyrano[2,3-b][1,4]benzodioxin-4-one dihydrochloride pentahydrate |
CAS | 22189-32-8 |
EINECS | 606-950-8 |
化学式 | C14H24N2O7.2HCl.5H2O |
分子量 | 495.35 |
InChI | InChI=1/C14H24N2O7.2ClH.5H2O/c1-5-4-6(17)14(20)13(21-5)22-12-10(19)7(15-2)9(18)8(16-3)11(12)23-14;;;;;;;/h5,7-13,15-16,18-20H,4H2,1-3H3;2*1H;5*1H2/t5-,7-,8+,9+,10+,11-,12-,13+,14+;;;;;;;/m1......./s1 |
InChIKey | DCHJOVNPPSBWHK-UXXUFHFZSA-N |
熔点 | 205-207° (dec) |
沸点 | 583.1°C at 760 mmHg |
比旋光度 | D +14.8° (c = 0.42 in water) |
闪点 | 306.4°C |
水溶性 | Soluble in water.Soluble in water, methanol, dimethyl sulfoxide, ethanol and dimethyl formamide. |
蒸汽压 | 5.05E-16mmHg at 25°C |
溶解度 | H2O: 50毫克/毫升,透明,淡黄 |
存储条件 | 2-8°C |
外观 | 粉末 |
颜色 | white to off-white |
Merck | 14,8739 |
BRN | 5684150 |
MDL号 | MFCD00150886 |
体外研究 | Spectinomycin selectively inhibits protein synthesis in cells and in extracts of Escherichia coli . When added to an exponentially growing culture, spectinomycin (50 μg/mL) rapidly and reversibly inhibits growth of Escherichia coli . Amino acid incorporation is slowed immediately but RNA synthesis continued. In extracts of Escherichia coli B, spectinomycin inhibits polypeptide synthesis directed either by endogenous messenger RNA or by MS-2 bacteriophage RNA. Maximum inhibition (70 to 80%) is achieved at 1 μg/mL (3 μM). . Spectinomycin blocks the translocation of peptidyl-tRNAs from the A-site to the P-site by inhibiting the binding of elongation factor G to the ribosome. Spectinomycin interacts specifically with the residues G1064 and 01192 in 16S rRNA and potentially change this molecule into an inactive conformation. Spectinomycin acts as a mixed noncompetitive inhibitor for the td intron RNA with a K i of 7.2 mM. The splicing inhibition by spectinomycin is dependent on pH changes and Mg 2+ concentration, indicating electrostatic interactions with the intron RNA. |
体内研究 | Renal excretion is a major elimination pathway for spectinomycin. Following IV administration, approximately 55% of the drug is excreted into the urine in unchanged form. After IV administration of 10 mg/kg spectinomycin shows a peak plasma concentration of 37.8 μg/mL and a systemic exposure (area-under the curve AUC 0-∞ ) of 15.7 μg/mL. Following single dose intramuscular administration, the overall elimination half-life of spectinomycin is 1.2 h in cattle, 1.0 h in sheep, 1.0 h in pigs, 1.65 h in chicken and 1.85 h in humans. |
安全术语 | 24/25 - 避免与皮肤和眼睛接触。 |
WGK Germany | 2 |
RTECS | WG7400000 |
FLUKA BRAND F CODES | 10 |
海关编号 | 29419090 |
参考资料 展开查看 | 1. 张济培, 韦庆兰, 谭华龙,等. 广东水禽源大肠埃希菌耐药性及氨基糖苷类耐药基因研究[J]. 动物医学进展, 2016, 37(005):42-46. |
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