(2S,3R)-2-(3,4,5-三羟基苯基)-3,4-二氢-1(2H)-苯并-3,5,7-三醇3-(3,4,5-三羟基苯甲酸)

中文名	没食子儿茶素没食子酸酯
英文名	(-)-Gallocatechin gallate
别名	没食子儿茶素没食子酸没食子儿茶素没食子酸酯 (-)-没食子酸儿茶酸没食子酸儿茶素没食子酸酯 (-)-倍儿茶素没食子酸盐 (-)-没食子儿茶素没食子酸酯 (2S,3R)-2-(3,4,5-三羟基苯基)-3,4-二氢-1(2H)-苯并-3,5,7-三醇3-(3,4,5-三羟基苯甲酸)
英文别名	GCG CCRIS 9286 Gallocatechin gallat (-)-gallocatecholgallate (-)-Gallocatechin gallate (-)-Gallocatechol gallate Glicentin-related polypeptide Gallic acid, catechin gallate Gallocatechol, 3-gallate, (-)- (8CI) (2s-trans)-henyl)-2h-1-benzopyran-3-yleste (2S,3R)-2-(3,4,5-Trihydroxyphenyl)-3,4-dihydro-1 (2H)-benzopyran-3,5,7-triol 3-(3,4,5-trihydroxybenzoate) (2S,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate Benzoic acid, 3,4,5-trihydroxy-, 3,4-dihydro-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-2H-1-benzopyran-3-yl ester, (2S-trans)-
CAS	4233-96-9
EINECS	636-979-1
化学式	C22H18O11
分子量	458.37
InChI	InChI=1/C22H18O11/c23-10-5-12(24)11-7-18(33-22(31)9-3-15(27)20(30)16(28)4-9)21(32-17(11)6-10)8-1-13(25)19(29)14(26)2-8/h1-6,18,21,23-30H,7H2/t18-,21+/m1/s1
密度	1.90±0.1 g/cm3(Predicted)
熔点	>179oC (dec.)
沸点	909.1±65.0 °C(Predicted)
闪点	320°C
蒸汽压	3.71E-35mmHg at 25°C
溶解度	DMSO (微溶) 、甲醇 (微溶)
折射率	1.857
酸度系数	7.75±0.25(Predicted)
存储条件	2-8°C
外观	整洁
颜色	Off-White to Pale Brown
物化性质	白色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于茶叶。
MDL号	MFCD00214298
体外研究	The amount of (-)-Gallocatechin gallate does not differ in leaves of different stages, and the content is relatively low. (−)-gallocatechin gallate in combination with active catechins ((−)-epigallocatechin gallate) has synergistic effects on the induction of apoptosis and inhibition of cell growth for PC-9 cells. (−)-gallocatechin gallate shows inhibitory effect on α-Glucosidase and DPPH, with IC 50 s of 30.2 μM and 12.2 μg/mL.
危险品标志	Xi - 刺激性物品
风险术语	36/37/38 - 刺激眼睛、呼吸系统和皮肤。
安全术语	S26 - 不慎与眼睛接触后，请立即用大量清水冲洗并征求医生意见。 S36 - 穿戴适当的防护服。 S26/36 -
WGK Germany	3
RTECS	DH9000000
海关编号	29329990
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(2S,3R)-2-(3,4,5-三羟基苯基)-3,4-二氢-1(2H)-苯并-3,5,7-三醇3-(3,4,5-三羟基苯甲酸) - 简介

没食子儿茶素（Epigallocatechin）是一种天然存在于茶叶中的化合物，属于儿茶素类化合物。没食子酸酯（Epigallocatechin gallate，简称EGCG）是没食子儿茶素的酯化衍生物。

没食子儿茶素和没食子酸酯具有以下性质：
- 外观：没食子儿茶素是无色结晶粉末，而没食子酸酯是黄绿色结晶固体。
- 溶解性：没食子儿茶素和没食子酸酯都能溶解于水和一些有机溶剂中。
- 抗氧化性：没食子儿茶素和没食子酸酯都具有很强的抗氧化活性，能够清除体内的自由基，有助于预防氧化应激引起的损伤。
- 抗菌性：没食子酸酯具有抗菌作用，对多种细菌和病毒具有一定的抑制作用。

没食子儿茶素和没食子酸酯的用途主要有以下几方面：

没食子儿茶素和没食子酸酯的制法一般包括提取和纯化过程。提取通常采用乙酸乙酯、甲醇或水作为溶剂，使用溶剂提取或萃取制备出没食子儿茶素。而没食子酸酯则需要将没食子儿茶素与没食子酸反应，生成没食子酸酯。纯化多采用柱层析、高效液相色谱、凝胶电泳等技术手段。

安全信息：没食子儿茶素和没食子酸酯属于天然产物，一般使用时不会引起明显的副作用。但过量摄入可能会导致一些不适症状，如胃痛、头晕、恶心等。在使用过程中应遵循适量原则。另外，个别人群如孕妇、婴幼儿及对茶叶过敏的人群，应避免或谨慎使用。

最后更新：2024-04-09 20:48:19

(2S,3R)-2-(3,4,5-三羟基苯基)-3,4-二氢-1(2H)-苯并-3,5,7-三醇3-(3,4,5-三羟基苯甲酸)

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