中文名 | 二苯甲酰甲烷 |
英文名 | Dibenzoylmethane |
别名 | 二苯甲酰甲烷 二苯甲醯甲烷 二苯甲酰基甲烷 ω-苯甲酰基苯乙酮 1,3-二苯基丙二酮 二苯甲酰基甲烷(DBM) 二苯甲酰基甲烷(DMB) 1,3-二苯基丙二酮 DBM 1,3-二苯基-1,3-丙二酮 |
英文别名 | DBM Dppd-H rhodiastab83 Dibenzoylmethane phenylphenacylketone 1,3-Diphenylpropanedione Phenyl-hydroxystyrylketone 1,3-diphenyl-3-propanedione 1,3-Diphenyl-1,3-propanedione ,3-Diphenyl-propane-1,3-dione 1,3-Diphenylpropane-1,3-dione 1,3-Diphenyl-1,3-propanediamine (2Z)-3-hydroxy-1,3-diphenylprop-2-en-1-one |
CAS | 120-46-7 |
EINECS | 204-398-9 |
化学式 | C15H12O2 |
分子量 | 224.25 |
InChI | InChI=1/C15H12O2/c16-14(12-7-3-1-4-8-12)11-15(17)13-9-5-2-6-10-13/h1-11,16H/b14-11- |
InChIKey | NZZIMKJIVMHWJC-UHFFFAOYSA-N |
密度 | 0.800 g/cm3 |
熔点 | 77-79°C(lit.) |
沸点 | 219-221°C18mm Hg(lit.) |
闪点 | 219-221°C/18mm |
水溶性 | It is Soluble in ether, chloroform, and aqueous sodium hydroxide. Insoluble in water. |
蒸汽压 | 0.01Pa at 20℃ |
溶解度 | 氯仿 (微溶) 、甲醇 (微溶,超声处理) |
折射率 | 1.6600 (estimate) |
酸度系数 | 8.95±0.10(Predicted) |
存储条件 | Store below +30°C. |
稳定性 | 稳定。与强氧化剂不相容。 |
外观 | 晶体 |
颜色 | Light yellow to yellow |
Merck | 14,3009 |
BRN | 514910 |
物化性质 | 无色斜方形片状结晶。熔点81℃,沸点219℃(2.4kPa)。易溶于氯醇、氯仿,能溶于氢氧化钠溶液,不溶于碳酸钠溶液,极微溶于水。 |
MDL号 | MFCD00003085 |
体外研究 | Dibenzoylmethane (10, 20, 30, 40, 50 μM; 6 hours) treatment concentration-dependently increases the mRNA level of HO-1 but has no effect on the mRNA level of Nrf2 in HepG2 cells. Dibenzoylmethane induces HO-1 and Nrf2 protein expression, and the induction diminishes after 12 h. Dibenzoylmethane (10, 20, 30, 40, 50 μM; 2 hours) concentration-dependently increases the phosphorylated protein levels of Erk1/2, p38MAPK, JNK, AMPK, and Akt in HepG2 cells. Dibenzoylmethane does not show significant cytotoxicity. |
体内研究 | Dibenzoylmethane (200, 500 mg/kg/day; ip; for three consecutive days) pretreatment significantly reduces both the area and the severity of necrosis, as well as the leukocyte infiltration, at a dose of 200 mg/kg in wild-type and Nrf2 knockout mice. Dibenzoylmethane protectes against CCl4-induced (1:49,v/v, 10 ml/kg) liver damage in wild-type mice. |
危险品标志 | Xi - 刺激性物品 |
风险术语 | 36/37/38 - 刺激眼睛、呼吸系统和皮肤。 |
安全术语 | S22 - 切勿吸入粉尘。 S24/25 - 避免与皮肤和眼睛接触。 |
WGK Germany | 3 |
RTECS | TZ1930000 |
TSCA | Yes |
海关编号 | 29143900 |
Hazard Note | Irritant |
下游产品 | 1,2-双(对甲苯基磺酰基)肼 |
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