148411-57-8
壳寡糖(Chitosan oligosaccharide)
CAS: 148411-57-8
化学式: C12H24N2O9
| 中文名 | 壳寡糖 |
| 英文名 | Chitosan oligosaccharide |
| 别名 | 壳寡糖 壳寡糖价格 壳寡糖作用 食品级壳寡糖 壳聚糖寡糖乳酸 壳聚糖寡糖HCL 壳聚糖低聚乳酸酯 |
| 英文别名 | Chitosan lactate (ester) Chitosan oligosaccharide Chitosan Olibosaccharide Chitosan oligosaccharide HCl Chitosan oligosaccharide (COS) CHITOSAN OLIGOSACCHARIDE LACTATE Chitosan 2-hydroxypropanoate (ester) Chitosan oligosaccharide,chito-oligosaccharide Chitosan oligosaccharide lactate average Mn 5,000 |
| CAS | 148411-57-8 |
| 化学式 | C12H24N2O9 |
| 分子量 | 340.32696 |
| 溶解度 | 溶于水 |
| 存储条件 | 2-8℃ |
| 敏感性 | Easily absorbing moisture |
| 外观 | 粉末 |
| 体外研究 | Chitosan oligosaccharide (COS) represents a class of natural polymers that holds therapeutic promise in several diseases due to not only its physiochemical properties including water-solubility and low viscosity but also its favorable pharmacological properties including good pharmacokinetics and safety profiles and diverse beneficial biological activities. Activation of AMPK and inhibition of inflammatory signaling pathways including NF-κB and MAPK pathways are recognized as major mechanisms responsible for several effects of Chitosan oligosaccharide (COS) including anti-inflammation, anti-cancer, and anti-diabetes. COS can interrupt cancer progression at multiple stages by modulating several signaling proteins/pathways including NF-κB, AMPK, mTOR, caspase-3, CD147, MMP-2, MMP-9, and VEGF. In vitro experiments have demonstrated that Chitosan oligosaccharide (COS) induced the death of several cancer cell types including ascites, bladder cancer, prostate cancer, lung cancer, liver cancer, leukemia, cervical cancer and colorectal cancer. The values of IC 50 of Chitosan oligosaccharide (COS) in inducing cytotoxicity are 25 μg/mL-50 μg/mL depending on types of cancer cells. |
| 体内研究 | The oral administration of Chitosan oligosaccharide (16 mg/kg/day) suppresses the production of the proinflammatory cytokines involved in allergic reactions, i.e., IL-4, IL-13 and TNF-α, in the lung tissues and bronchoalveolar lavage fluid of the mice. Last, an anti-inflammatory effect of Chitosan oligosaccharide (COS) on lymphocyte activation has been documented in a rat model of autoimmune anterior uveitis induced by immunization with bovine melanin-associated antigen. Chitosan oligosaccharide (COS) inhibits UV-induced macroscopic appearance in mice skin. Compared with healthy dorsal skin with smoothness and some shallow wrinkles of hairless mice in normal control group, UV exposure for 10 weeks triggers skin erythema, dry, thickening, sagging and coarse wrinkles, and even leathery appearance and slight flesh-colored lesion in the model mice, the visual score of which is markedly higher than that of the normal control group (p<0.05), indicating that UV induces photoaging in skin surface. |
| WGK Germany | 3 |
| 参考资料 展开查看 | 1. 吴倩, 罗建泉, 李苏爽,等. 基于聚多巴胺涂层的吸附膜在黄曲霉毒素去除中的应用[J]. 膜科学与技术, 2019, v.39;No.196(03):91-101. 2. 杨强剑, 罗建泉, 郭世伟,等. 聚醚砜超滤膜处理糖蜜中的膜污染控制[J]. 膜科学与技术, 2019. 3. 周伟, 胡熠, 张进杰,等. 杨梅素和糖基化协同改性鱼鳞明胶可食膜[J]. 食品与发酵工业, 2018, 44(006):58-66. 4. 许值铭. 壳寡糖基原位掺N多孔碳材料的合成与表征[D].贵州大学,2020. 5. Jinfeng Mei, Hui Zhang, Zhongyu Li, Hongxiang Ou,A novel tetraethylenepentamine crosslinked chitosan oligosaccharide hydrogel for total adsorption of Cr(VI),Carbohydrate Polymers,Volume 224,2019,115154,ISSN 0144-8617,https://doi.org/10.1016/j.carbpo 6. [IF=9.381] Jinfeng Mei et al."Prominent adsorption of Cr(VI) with graphene oxide aerogel twined with creeper-like polymer based on chitosan oligosaccharide."Carbohyd Polym. 2020 Nov;247:116733 7. [IF=9.381] Jinfeng Mei et al."A novel tetraethylenepentamine crosslinked chitosan oligosaccharide hydrogel for total adsorption of Cr(VI)."Carbohyd Polym. 2019 Nov;224:115154 8. [IF=5.268] Yabo Fu et al."Preparation and performance of a BTDA-modified polyurea microcapsule for encapsulating avermectin."Colloid Surface B. 2019 Nov;183:110400 9. [IF=3.693] Mei Qixiang et al."Porous COS@SiO2 Nanocomposites Ameliorate Severe Acute Pancreatitis and Associated Lung Injury by Regulating the Nrf2 Signaling Pathway in Mice."Front Chem. 2020 Oct;0:720 10. [IF=3.298] Guangben Wei et al."Immune effect of Vibrio harveyi formalin-killed cells vaccine combined with chitosan oligosaccharide and astragalus polysaccharides in ♀Epinephelus fuscoguttatus×♂Epinephelus lanceolatus."Fish Shellfish Immun. 2020 Mar;98:186 11. [IF=3.196] Zhongxin Yang et al."Fabrication of KDF-loaded chitosan-oligosaccharide-encapsulated konjac glucomannan/sodium alginate/zeolite P microspheres with sustained-release antimicrobial activity."J Mol Struct. 2022 Feb;1250:131682 12. [IF=1.748] Yilin Zhang et al."The effect of chitosan oligosaccharide as an immune enhancer against Vibrio harveyi in pearl gentian grouper (♀Epinephelus fuscoguttatus × ♂Epinephelus lanceolatus)."Aquac Res. 2021 Feb;52(2):541-546 13. [IF=4.35] Peilong Liao et al."The Layered Encapsulation of Vitamin B2 and β-Carotene in Multilayer Alginate/Chitosan Gel Microspheres: Improving the Bioaccessibility of Vitamin B2 and β-Carotene."Foods. 2022 Jan;11(1):20 14. [IF=4.598] ZhongXin Yang et al."Construction of sodium alginate/konjac glucomannan/chitosan oligosaccharide/Zeolite P hydrogel microspheres loaded with potassium diformate for sustained intestinal bacterial inhibition."EUROPEAN POLYMER JOURNAL. 2022 Jun;172:111233 |
148411-57-8 - 简介
壳寡糖是一类由葡萄糖分子组成的多糖化合物。它具有以下性质：
结构稳定：壳寡糖是由多个葡萄糖分子通过特定的连接方式组成，具有较高的结构稳定性。
溶解性：壳寡糖在水中具有较好的溶解性，可以形成透明溶液。
生物活性：壳寡糖具有多种生物活性，包括抗菌、抗病毒、抗氧化、抗肿瘤和免疫调节等作用。
壳寡糖的制备方法：
微生物发酵法：通过采用适当的微生物（如真菌或海洋细菌）利用废弃物或天然聚糖产生壳寡糖。
酶法：利用特定酶催化废弃物或天然聚糖，生成壳寡糖。
化学合成法：通过化学反应合成壳寡糖，该方法成本较高，用途较少。
壳寡糖的安全信息：一般来说，壳寡糖是一种天然产物，较为安全。每种具体的壳寡糖可能存在差异，在使用时需要参考具体产品的说明书，并遵守相关安全操作规范。对于过敏体质的人群，可能会引发过敏反应，应谨慎使用。
结构稳定：壳寡糖是由多个葡萄糖分子通过特定的连接方式组成，具有较高的结构稳定性。
溶解性：壳寡糖在水中具有较好的溶解性，可以形成透明溶液。
生物活性：壳寡糖具有多种生物活性，包括抗菌、抗病毒、抗氧化、抗肿瘤和免疫调节等作用。
壳寡糖的制备方法：
微生物发酵法：通过采用适当的微生物（如真菌或海洋细菌）利用废弃物或天然聚糖产生壳寡糖。
酶法：利用特定酶催化废弃物或天然聚糖，生成壳寡糖。
化学合成法：通过化学反应合成壳寡糖，该方法成本较高，用途较少。
壳寡糖的安全信息：一般来说，壳寡糖是一种天然产物，较为安全。每种具体的壳寡糖可能存在差异，在使用时需要参考具体产品的说明书，并遵守相关安全操作规范。对于过敏体质的人群，可能会引发过敏反应，应谨慎使用。
最后更新：2024-04-09 21:54:55
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