2-溴-2-(2-氟苯基)-1-环丙乙酮

中文名	Indibulin
英文名	Indibulin
别名	化合物INDIBULIN 2-溴-2-(2-氟苯基)-1-环丙乙酮 2-(1-(4-氯苄基)-1H-吲哚-3-基)-2-氧代-N-(吡啶-4-基)乙酰胺
英文别名	ZIO 301 Nascapine lindiblin Indibulin 2-[1-(4-Chlorobenzyl)-1H-indol-3-yl]-2-oxo-N-pyridin-4-ylacetamide 2-[1-(4-chlorobenzyl)-1H-indol-3-yl]-2-oxo-N-(pyridin-4-yl)acetamide 1H-Indole-3-acetamide, 1-[(4-chlorophenyl)methyl]-α-oxo-N-4-pyridinyl- 2-[1-[(4-chlorophenyl)methyl]indol-3-yl]-2-oxo-N-pyridin-4-ylacetamide 2-(1-(4-Chlorophenylmethyl)-1H-indol-3-yl)-2-oxo-N-(pyridin-4-yl)acetamide
CAS	204205-90-3
化学式	C22H16ClN3O2
分子量	389.83
InChI	InChI=1/C22H16ClN3O2/c23-16-7-5-15(6-8-16)13-26-14-19(18-3-1-2-4-20(18)26)21(27)22(28)25-17-9-11-24-12-10-17/h1-12,14H,13H2,(H,24,25,28)
密度	1.31±0.1 g/cm3(Predicted)
折射率	1.664
酸度系数	9.38±0.70(Predicted)
存储条件	Sealed in dry,Store in freezer, under -20°C
体外研究	Indibulin (300-2100 nM; 48 hours) inhibits the proliferation of MCF-7 cells with an IC50 of 150 nM. Indibulin (300, 600 nM; 48 hours) blockes the cells in the G2/M phase indicating that indibulin blockes the progression of the cell cycle at mitosis. Indibulin (150-600 nM; 24 hours) induces apoptosis in MCF-7 cells. Indibulin (150-600 nM; 48 hours) with 300 and 600 nM generates cleaved fragments of PARP protein the treatment of MCF-7 cells. Cell Proliferation Assay Cell Line: MCF-7 cells Concentration: 300, 600, 900, 1200, 1500, 1800, 2100 nM Incubation Time: 48 hours Result: Inhibited the proliferation of MCF-7 cells with an IC 50 of 150 nM. Cell Cycle Analysis Cell Line: MCF-7 cells Concentration: 300, 600 nM Incubation Time: 48 hours Result: Blocked the cells in the G2/M phase of the cell cycle. Apoptosis Analysis Cell Line: MCF-7 cells Concentration: 150, 300 and 600 nM Incubation Time: 24 hours Result: Induced apoptosis in MCF-7 cells. Western Blot Analysis Cell Line: MCF-7 cells Concentration: 150, 300 and 600 nM Incubation Time: 48 hours Result: Generated cleaved fragments of PARP protein in 300 and 600 nM.

2-溴-2-(2-氟苯基)-1-环丙乙酮 - 配置溶液浓度参考

	1mg	5mg	10mg
1 mM	2.565 ml	12.826 ml	25.652 ml
5 mM	0.513 ml	2.565 ml	5.13 ml
10 mM	0.257 ml	1.283 ml	2.565 ml
5 mM	0.051 ml	0.257 ml	0.513 ml

最后更新：2024-01-02 23:10:35

北京索莱宝科技有限公司

现货供应

产品名: Indibulin 去供应商网站查看询盘
CAS: 204205-90-3
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规格: II2850-1mg,1mg
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上海吉至生化科技有限公司

现货供应

产品名: 2-(1-(4-氯苄基)-1H-吲哚-3-基)-2-氧代-N-(吡啶-4-基)乙酰胺去供应商网站查看询盘
CAS: 204205-90-3
产地: 中国上海
包装: 10mg
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产品描述: 中文名：2-(1-(4-氯苄基)-1H-吲哚-3-基)-2-氧代-N-(吡啶-4-基)乙酰胺英文名:Indibulin CAS:204205-90-3 规格: 更多

上海麦克林生化科技股份有限公司

现货供应

产品名: Indibulin (ZIO 301) 去供应商网站查看询盘
CAS: 204205-90-3
产地: 上海
规格: I911172
价格: 250mg-1089,100mg-640,1ml-205
库存: 7天内发货
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上海源叶生物科技有限公司

产品名: Indibulin (ZIO 301) 去供应商网站查看询盘
CAS: 204205-90-3
产地: 上海
规格: 98%
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