2-Propen-1-one, 1-(2,4-dihydroxyphenyl)-3-(4-(beta-D-glucopyranosyloxy)phenyl)-, (2E)-
异甘草苷(4-[(1E)-3-(2,4-dihydroxyphenyl)-3-oxoprop-1-en-1-yl]phenyl beta-D-glucopyranoside)
CAS: 5041-81-6
化学式: C21H22O9
| 中文名 | 异甘草苷 |
| 英文名 | 4-[(1E)-3-(2,4-dihydroxyphenyl)-3-oxoprop-1-en-1-yl]phenyl beta-D-glucopyranoside |
| 别名 | 异甘草 异甘草甙 异甘草苷 异甘草苷对照品, 异甘草苷(标准品) 异甘草苷(异甘草甙) ISOLIQUIRITIN 异甘草苷 异甘草苷 ISOLIQUIRITIN 标准品 |
| 英文别名 | Aids004475 Aids-004475 ISOLIQUIRITIN isoliquiritin neoisoliquritin 2',4,4'-Trihydroxychalcone 4-(beta-D-glucopyranoside) [(E)-2',4'-Dihydroxychalcone-4-yl]β-D-glucopyranoside (E)-1-(2,4-Dihydroxyphenyl)-3-[4-(β-D-glucopyranosyloxy)phenyl]-2-propen-1-one 4-[(1E)-3-(2,4-dihydroxyphenyl)-3-oxoprop-1-en-1-yl]phenyl beta-D-glucopyranoside 2-Propen-1-one, 1-(2,4-dihydroxyphenyl)-3-(4-(beta-D-glucopyranosyloxy)phenyl)-, (2E)- 2-Propen-1-one, 1-(2,4-dihydroxyphenyl)-3-[4-(.beta.-D-glucopyranosyloxy)phenyl]-, (2E)- |
| CAS | 5041-81-6 |
| EINECS | 1308068-626-2 |
| 化学式 | C21H22O9 |
| 分子量 | 418.39 |
| InChI | InChI=1/C21H22O9/c22-10-17-18(26)19(27)20(28)21(30-17)29-13-5-1-11(2-6-13)3-8-15(24)14-7-4-12(23)9-16(14)25/h1-9,17-23,25-28H,10H2/b8-3+/t17-,18-,19+,20-,21-/m1/s1 |
| 密度 | 1.528 |
| 熔点 | 185-186℃ |
| 沸点 | 743.5±60.0 °C(Predicted) |
| 比旋光度 | -60.8 |
| 闪点 | 263.2°C |
| 蒸汽压 | 3.26E-23mmHg at 25°C |
| 溶解度 | 溶于甲醇和DMSO |
| 折射率 | 1.706 |
| 酸度系数 | 7.46±0.35(Predicted) |
| 存储条件 | 2-8℃ |
| 外观 | 黄色针状结晶 |
| 物化性质 | 黄色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于甘草。 |
| MDL号 | MFCD00272145 |
| 参考资料 展开查看 | 1. 刘秀琨, 陈颖, 冉棋,等. 芍药-甘草不同配伍比例提取物中有效成分溶出规律的研究[J]. 天津中医药大学学报, 2019. 2. 周越美, 冯超, 史煜华,等. 甘草浸膏HPLC指纹图谱及多指标成分含量测定研究[J]. 中国现代应用药学, 2020, v.37(09):26-31. 3. 刘效栓,肖正国,罗燕燕,李喜香,李季文,毕映燕,刘军刚.基于指纹图谱与一测多评技术分析化学转化法富集甘草药渣总黄酮的研究[J].中国中医药信息杂志,2018,25(01):69-73. 4. 程丽娜, 曹世杰, 曲明,等. 甘草主要成分改善L6大鼠成肌细胞胰岛素抵抗的机制[J]. 中国实验方剂学杂志, 2020(4). 5. 李淑娟,李红俊,吕晓东,姚彩红,周莎.两种黄酮小分子与人血清白蛋白相互作用的研究[J].广州化工,2020,48(19):40-42. 6. 蔡淑慧,赵华聪,贾萌,赵晓莉,池玉梅,张雯,王洪兰,狄留庆.基于HPLC指纹图谱和多成分定量分析的炒甘草饮片质量评价研究[J].中国中药杂志,2021,46(01):118-124. 7. 纪万里,周泽华,王婷婷,安叡,梁琨,王新宏.基于UPLC-LTQ-Orbitrap-MS方法分析半夏泻心汤化学成分[J].药物分析杂志,2020,40(10):1736-1750. 8. Yang, Ruocong, et al. "Chemical composition and pharmacological mechanism of Qingfei Paidu Decoction and Ma Xing Shi Gan Decoction against Coronavirus Disease 2019 (COVID-19): in silico and experimental study." Pharmacological research 157 (2020): 104820.h 9. Li-Mei Feng, Yan-Yan Chen, Ding-Qiao Xu, Rui-Jia Fu, Shi-Jun Yue, Qi Zhao, Yu-Xi Huang, Xue Bai, Mei Wang, Li-Ming Xing, Yu-Ping Tang, Jin-Ao Duan,An integrated strategy for discovering effective components of Shaoyao Gancao decoction for treating neuropa 10. Li-Mei Feng, Yan-Yan Chen, Ding-Qiao Xu, Rui-Jia Fu, Shi-Jun Yue, Qi Zhao, Yu-Xi Huang, Xue Bai, Mei Wang, Li-Ming Xing, Yu-Ping Tang, Jin-Ao Duan,An integrated strategy for discovering effective components of Shaoyao Gancao decoction for treating neuropa 11. Han, C. H. E. N., et al. "Chemical profile of the active fraction of Yi-Gan San by HPLC-DAD-Q-TOF-MS and its neuroprotective effect against glutamate-induced cytotoxicity." Chinese journal of natural medicines 12.11 (2014): 869-880.https://doi.org/10.1016/ 12. Zhang, Jing, et al. "Application of “spider-web” mode in discovery and identification of Q-markers from Xuefu Zhuyu capsule." Phytomedicine 77 (2020): 153273.https://doi.org/10.1016/j.phymed.2020.153273 13. Valkó, Klára. "Application of high-performance liquid chromatography based measurements of lipophilicity to model biological distribution." Journal of chromatography A 1037.1-2 (2004): 299-310.https://doi.org/10.1016/j.chroma.2003.10.084 14. Valkó, Klára. "Application of high-performance liquid chromatography based measurements of lipophilicity to model biological distribution." Journal of chromatography A 1037.1-2 (2004): 299-310.https://doi.org/10.1016/j.chroma.2003.10.084 15. [IF=6.057] Zhihong Li et al."New MS network analysis pattern for the rapid identification of constituents from traditional Chinese medicine prescription Lishukang capsules in vitro and in vivo based on UHPLC/Q-TOF-MS."Talanta. 2018 Nov;189:606 16. [IF=4.411] Jifeng Gu et al."Application of High-Performance Liquid Chromatography Coupled with Linear Ion Trap Quadrupole Orbitrap Mass Spectrometry for Qualitative and Quantitative Assessment of Shejin-Liyan Granule Supplements."Molecules. 2018 Apr;23(4):884 17. [IF=3.361] Huanyu Guan et al."Comparative intestinal bacteria-associated pharmacokinetics of 16 components of Shengjiang Xiexin decoction between normal rats and rats with irinotecan hydrochloride (CPT-11)-induced gastrointestinal toxicity in vitro using salting-out 18. [IF=3.205] Zhuangzhuang Li et al."Simultaneous quantification of fifteen compounds in rat plasma by LC-MS/MS and its application to a pharmacokinetic study of Chaihu-Guizhi decoction."J Chromatogr B. 2019 Jan;1105:15 19. [IF=3] Han CHEN et al."Chemical profile of the active fraction of Yi-Gan San by HPLC-DAD-Q-TOF-MS and its neuroprotective effect against glutamate-induced cytotoxicity."Chin J Nat Medicines. 2014 Nov;12:869 20. [IF=11.413] Yan Yin et al."De novo biosynthesis of liquiritin in Saccharomyces cerevisiae."Acta Pharm Sin B. 2020 Apr;10:711 21. [IF=6.953] Dan Jiang et al."Molecular cloning and functional characterization of UGTs from Glycyrrhiza uralensis flavonoid pathway."Int J Biol Macromol. 2021 Dec;192:1108 22. [IF=5.893] Ruocong Yang et al."Chemical composition and pharmacological mechanism of Qingfei Paidu Decoction and Ma Xing Shi Gan Decoction against Coronavirus Disease 2019 (COVID-19): In silico and experimental study."Pharmacol Res. 2020 Jul;157:104820 23. [IF=5.34] Jing Zhang et al."Application of “spider-web” mode in discovery and identification of Q-markers from Xuefu Zhuyu capsule."Phytomedicine. 2020 Oct;77:153273 24. [IF=4.769] Zhenzhong Yang et al."Deciphering bioactive compounds of complex natural products by tandem mass spectral molecular networking combined with an aggregation-induced emission based probe."J Pharm Anal. 2020 Nov;: 25. [IF=4.36] Li-Mei Feng et al."An integrated strategy for discovering effective components of Shaoyao Gancao decoction for treating neuropathic pain by the combination of partial least-squares regression and multi-index comprehensive method."J Ethnopharmacol. 2020 Oc 26. [IF=3.361] Yuhao Zhang et al."An integrated approach for structural characterization of Gui Ling Ji by traveling wave ion mobility mass spectrometry and molecular network."Rsc Adv. 2021 Apr;11(26):15546-15556 27. [IF=2.629] Li Tingting et al."Quality Assessment of Licorice Based on Quantitative Analysis of Multicomponents by Single Marker Combined with HPLC Fingerprint."Evid-Based Compl Alt. 2021;2021:8834826 28. [IF=1.885] Xia Wenxin et al."Study on the Spectrum-Effect Relationship of the Traditional Effect of Saponins in Glycyrrhiza uralensis Fisch."Int J Anal Chem. 2021;2021:6617033 29. [IF=5.545] Yuxuan Han et al."Multi-dimensional "projection" - the impact of abiotic stresses on the content of seven active compounds and expression of related genes in Glycyrrhiza uralensis Fisch."Environ Exp Bot. 2022 May;197:104846 30. [IF=4.36] Shasha Kong et al."Synergistic mechanism for the bioactivity fortification of licorice by honey."J Ethnopharmacol. 2022 May;289:115048 31. [IF=4.412] Haifan Liu et al."Pharmacokinetics, Prostate Distribution and Metabolic Characteristics of Four Representative Flavones after Oral Administration of the Aerial Part of Glycyrrhiza uralensis in Rats."MOLECULES. 2022 Jan;27(10):3245 32. [IF=2.63] Zhou Peng et al."Exploring the Mechanism of Ling-Gui-Zhu-Gan Decoction in Ventricular Remodeling after Acute Myocardial Infarction Based on UPLC and In Vivo Experiments."Evidence-based Complementary and Alternative Medicine. 2022;2022:8593176 |
2-Propen-1-one, 1-(2,4-dihydroxyphenyl)-3-(4-(beta-D-glucopyranosyloxy)phenyl)-, (2E)- - 简介
异甘草苷是一种天然产物，也被称为甘草次苷或甘草次苷A。以下是关于异甘草苷的性质、用途、制法和安全信息的介绍：
性质：
- 异甘草苷是一种白色结晶性粉末，可溶于水和醇，但不溶于乙醚和苯。其化学结构为β-D-葡萄糖苷结合的酸性三萜类似物。
用途：
- 异甘草苷在中药方剂中常被用作清热解毒、镇咳止嗽的成分。
制法：
- 异甘草苷常通过甘草提取物进行分离、纯化得到。主要的提取方法包括水提、醇提和超声波提取等。
- 提取得到的甘草提取物经过酶法、纯化、脱色和结晶等步骤，可以得到纯度较高的异甘草苷。
安全信息：
- 异甘草苷属于自然产物，通常被认为是安全的。高剂量长期使用可能会引起一些副作用，如水钠潴留、钾丢失等。在使用异甘草苷时应注意剂量和使用时间，尤其是患有高血压、心脏病、肝功能不全等疾病的人需遵医嘱使用。
- 对于孕妇、哺乳期妇女和儿童，以及对异甘草苷过敏的人，不宜使用该物质。
性质：
- 异甘草苷是一种白色结晶性粉末，可溶于水和醇，但不溶于乙醚和苯。其化学结构为β-D-葡萄糖苷结合的酸性三萜类似物。
用途：
- 异甘草苷在中药方剂中常被用作清热解毒、镇咳止嗽的成分。
制法：
- 异甘草苷常通过甘草提取物进行分离、纯化得到。主要的提取方法包括水提、醇提和超声波提取等。
- 提取得到的甘草提取物经过酶法、纯化、脱色和结晶等步骤，可以得到纯度较高的异甘草苷。
安全信息：
- 异甘草苷属于自然产物，通常被认为是安全的。高剂量长期使用可能会引起一些副作用，如水钠潴留、钾丢失等。在使用异甘草苷时应注意剂量和使用时间，尤其是患有高血压、心脏病、肝功能不全等疾病的人需遵医嘱使用。
- 对于孕妇、哺乳期妇女和儿童，以及对异甘草苷过敏的人，不宜使用该物质。
最后更新：2024-04-09 20:48:19
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产品名: 异甘草苷Isoliquiritin 标准品 去供应商网站查看 询盘CAS: 5041-81-6
产地: 北京
包装: 瓶
规格: SI8230-20mg,20mg,II0390-5mg,5mg,II0390-10mg,10mg,II0390-20mg,20mg
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库存: 现询
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QQ: 3193328036
微信: 17801761073
产品描述: 产品覆盖：小分子化合物、分析对照品、染色试剂、生化试剂盒、细胞生物学、分子生物学、抗体、蛋白、多肽、ELISA试剂盒、微生物培养、化学合成、仪器耗材、CRO技术 更多
提供多种规格现货供应
产品名: Isoliquiritin 去供应商网站查看 询盘CAS: 5041-81-6
产地: 美国
包装: 10 mM * 1 mL;1 mg;5 mg;10 mg;25 mg
规格: HY-N0765
库存: 现货，货期：1-2天
电话: 021-38924433; 021-58955995
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提供多种规格现货供应
产品名: 异甘草苷Isoliquiritin 标准品 去供应商网站查看 询盘CAS: 5041-81-6
产地: 北京
包装: 瓶
规格: SI8230-20mg,20mg,II0390-5mg,5mg,II0390-10mg,10mg,II0390-20mg,20mg
价格: 电话、微信、QQ、邮件
库存: 现询
电话: 010-50973130
手机: 17801761073(微信同号)
电子邮件: 3193328036@qq.com
QQ: 3193328036
微信: 17801761073
产品描述: 产品覆盖：小分子化合物、分析对照品、染色试剂、生化试剂盒、细胞生物学、分子生物学、抗体、蛋白、多肽、ELISA试剂盒、微生物培养、化学合成、仪器耗材、CRO技术 更多
提供多种规格现货供应
产品名: Isoliquiritin 去供应商网站查看 询盘CAS: 5041-81-6
产地: 美国
包装: 10 mM * 1 mL;1 mg;5 mg;10 mg;25 mg
规格: HY-N0765
库存: 现货，货期：1-2天
电话: 021-38924433; 021-58955995
手机: 18019480960
电子邮件: sales@medchemexpress.cn
产品描述: 产品覆盖：8万多种抑制剂，11000+靶点蛋白，数百款试剂盒，200+生物活性化合物库，天然产物，抗体等. 纯度: 99.49%
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