4-三羟基-5-(2-异丙基苯基甲基)苯甲酰胺

中文名	TW-37
英文名	TW-37
别名	化合物TW37 N-[4-(2-叔丁基苯磺酰基)苯基]-2 4-三羟基-5-(2-异丙基苯基甲基)苯甲酰胺 BCL-2,BCL-XL和MCL-1抑制剂(TW-37) N-[4-(2-叔丁基苯磺酰基)苯基]-2,3,4-三羟基-5-(2-异丙基苯基)苯甲酰胺 N-[4-(2-叔丁基苯磺酰基)苯基]-2,3,4-三羟基-5-(2-异丙基苄基)苯甲酰胺 N-[4-(2-叔丁基苯磺酰基)苯基]-2,3,4-三羟基-5-(2-异丙基苯基甲基)苯甲酰胺
英文别名	TW-37 CS-299 N-[4-(2-tert-Butylphenylsulfonyl)phenyl]-2,3,4-trihydroxy-5-(2-isopropylbenzyl)benzamide 5-(2-isopropylbenzyl)-N-(4-(2-tert-butylphenylsulfonyl)phenyl)-2,3,4-trihydroxybenzamide N-[4-[(2-tert-Butylphenyl)sulfonyl]phenyl]-2,3,4-trihydroxy-5-[(2-isopropylphenyl)methyl]benzamide N-[4-[[2-(1,1-Dimethylethyl)phenyl]sulfonyl]phenyl]-2,3,4-trihydroxy-5-[[2-(1-methylethyl)phenyl]methyl]benzamide N-[4-[(2-tert-Butylphenyl)sulfonyl]phenyl]-2,3,4-trihydroxy-5-[(2-isopropylphenyl)methyl]benzamide TW-37 Bcl-2 Inhibitor N-[4-[(2-tert-Butylphenyl)sulfonyl]phenyl]-2,3,4-trihydroxy-5-[(2-isopropylphenyl)methyl]benzamide
CAS	877877-35-5
化学式	C33H35NO6S
分子量	573.7
密度	1.280
沸点	723.7±60.0 °C(Predicted)
酸度系数	7.86±0.50(Predicted)
存储条件	Store at -20°C
体外研究	TW-37 (TW37) is a novel nonpeptide small-molecule inhibitor designed using a structure-based design strategy. TW-37 targets the BH3-binding groove in Bcl-2 where proapoptotic Bcl-2 proteins, such as Bak, Bax, and Bid bind. In fluorescence polarization-based binding assays using recombinant Bcl-2 and Bcl-xL proteins, TW-37 binds to Bcl-2 and Bcl-xL with K i values of 290 and 1110 nM, respectively. TW-37 has an IC 50 of 1.8 μM for endothelial cells but shows no cytotoxic effects for fibroblasts at concentrations up to 50 μM. The mechanism of TW-37-induced endothelial cell death is apoptosis, in a process mediated by mitochondrial depolarization and activation of caspase-9 and caspase-3. The effect of TW-37 on endothelial cell apoptosis is not prevented by coexposure to the growth factor milieu secreted by tumor cells. Inhibition of the angiogenic potential of endothelial cells (i.e., migration and capillary sprouting assays) and expression of the angiogenic chemokines CXCL1 and CXCL8 are accomplished at subapoptotic TW-37 concentrations (0.005-0.05 μM). TW-37 is a potent Bcl-2 and Mcl-1 inhibitor. In fluorescence polarization-based binding assays using recombinant Bcl-2, Bcl-xL, and Mcl-1 proteins, TW-37 binds to Bcl-2, Bcl-xL, and Mcl-1 with K i values of 290, 1,110 and 260 nM, respectively.
体内研究	A murine model of humanized vasculature is used to investigate the biological effect of TW-37 (TW37) on human microvascular endothelial cell in vivo. Using this model, a significant decrease is observed in total blood vessel number (P<0.05) comparing both 3 and 30 mg/kg TW-37 against vehicle control. In addition to reduction in total number of blood vessels, an unusual number of occluded vessels are occurring in the treated groups. The levels of vessel occlusion are assessed by counting completely blocked vessels and determining their number as a percentage of total vessel number. TW-37 concentration mediates a significant increase in the number of occluded vessels when compared with control.

4-三羟基-5-(2-异丙基苯基甲基)苯甲酰胺 - 配置溶液浓度参考

	1mg	5mg	10mg
1 mM	1.743 ml	8.715 ml	17.43 ml
5 mM	0.349 ml	1.743 ml	3.486 ml
10 mM	0.174 ml	0.872 ml	1.743 ml
5 mM	0.035 ml	0.174 ml	0.349 ml

最后更新：2024-01-02 23:10:35

4-三羟基-5-(2-异丙基苯基甲基)苯甲酰胺 - 简介

TW-37是一种化合物，化学名称为1,3-二(2-异丙氨基)-3,4-二氢-6-甲基-2H-苯并异唑-5-酮。下面是关于TW-37的性质，用途，制法和安全信息的介绍：

性质：
- 外观：白色至类白色结晶粉末。
- 溶解性：TW-37在有机溶剂中溶解度较高。

用途：

制法：
- TW-37的制备方法可以通过化学合成来实现。具体的合成路线和操作条件可以在相关文献或专利中找到。

安全信息：
- TW-37的毒性和安全性信息目前尚不充分，在使用时应十分小心。

最后更新：2024-04-09 20:49:11

北京索莱宝科技有限公司

现货供应

产品名: TW-37/Bcl-2Inhibitor 去供应商网站查看询盘
CAS: 877877-35-5
产地: 北京
包装: 盒
规格: IT1280-5mg,5mg,IT1280-10mg,10mg
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上海吉至生化科技有限公司

现货供应

产品名: N-[4-(2-叔丁基苯磺酰基)苯基]-2,3,4-三羟基-5-(2-异丙基苯基甲基)苯甲酰胺去供应商网站查看询盘
CAS: 877877-35-5
产地: 中国上海
包装: 10mg
规格: 99%
价格: 1148.00
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产品描述: 中文名：N-[4-(2-叔丁基苯磺酰基)苯基]-2,3,4-三羟基-5-(2-异丙基苯基甲基)苯甲酰胺英文名:TW-37 CAS:877877-35-5 规格更多

上海麦克林生化科技股份有限公司

现货供应

产品名: N-[4-(2-叔丁基苯磺酰基)苯基]-2,3,4-三羟基-5-(2-异丙基苄基)苯甲酰胺去供应商网站查看询盘
CAS: 877877-35-5
产地: 上海
规格: N794741
价格: 1ml-1109,5mg-587,250mg-8047
库存: 7天内发货
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上海源叶生物科技有限公司

现货供应

产品名: TW-37 去供应商网站查看询盘
CAS: 877877-35-5
产地: 上海
规格: 96%
价格: 5mg 640,10mg 920,50mg 3360
库存: 现货
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