4-氨基-1-((2S,4S)-2-(羟甲基)-1,3-二氧戊环-4-基)嘧啶-2(1H)-酮

中文名	4-氨基-1-[(2S)-2-(羟甲基)-1,3-二氧杂环戊-4-基]嘧啶-2-酮
英文名	TROXACITABINE
别名	曲沙他滨拉米夫定杂质I 拉米夫定杂质09 拉米夫定EP杂质I 拉夫米定EP杂质I 拉米夫定杂质I(EP) 4-氨基-1-[(2S)-2-(羟甲基)-1,3-二氧杂环戊-4-基]嘧啶-2-酮 4-氨基-1-((2S,4S)-2-(羟甲基)-1,3-二氧戊环-4-基)嘧啶-2(1H)-酮
英文别名	CS-150 (-)-Occc (-)-Bch 204 TROXACITABINE Lamivudine Impurity I (Troxacitabine) 4-Amino-1-[(2S)-2-(hydroxymethyl)-1,3-dioxolan-4-yl]pyrimidin-2-one 4-amino-1-[(2S,4S)-2-(hydroxymethyl)-1,3-dioxolan-4-yl]-1,2-dihydropyrimidin-2-one TROXACITABINE,2(1H)-PYRIMIDINONE, 4-AMINO-1-(2-(HYDROXYMETHYL)-1,3-DIOXOLAN-4-YL)-, (2S-CIS)-
CAS	145918-75-8
EINECS	200-258-5
化学式	C8H11N3O4
分子量	213.19
密度	1.71±0.1 g/cm3(Predicted)
熔点	176-177°
沸点	422.5±55.0 °C(Predicted)
比旋光度	D25 -38.33° (c = 0.43 in MeOH).
溶解度	DMSO (微溶) 、甲醇 (微溶)
酸度系数	14.83±0.10(Predicted)
存储条件	2-8°C(protect from light)
稳定性	吸湿性
外观	固体
颜色	White to Off-White
体外研究	Troxacitabine has shown cutotoxicity in cancer cell lines of hepatocellular (HepG2), prostate (PC3, DUI45), non-small cell lung (NCI-H460, NCr-322M) colon (HT29), renal (CAK-l, A498, RXF-393, SNI2-C) and pancreatic origin (Pnac-Ol, MiaPa Ca) with IC 50 s range from 15-35 μM.
体内研究	Troxacitabine is highly active against the Panc-01 model, with TGI levels of 88.5% and 84.3% at the 10 and 25 mg/kg doses, respectively. The mean final tumor weights for animals given troxacitabine are also significantly smaller compared with vehicle controls. Troxacitabine has less activity against the MiaPaCa model. Troxacitabine is very effective in human RCC tumor xenograft models, including CAM-i, A498, RXF-393, and SN12C carcinomas. Very good responses are ob served in animals bearing CAM-i, A498, and RXF-393 RCC tumors given i.p. doses of 10, 25, and 50 mg/kg twice a day for 5 days.

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CAS: 145918-75-8
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产品名: 4-氨基-1-((2S,4S)-2-(羟甲基)-1,3-二氧戊环-4-基)嘧啶-2(1H)-酮去供应商网站查看询盘
CAS: 145918-75-8
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