53109-32-3
Cyclo(his-pro)(Cyclo(his-pro),Cyclo(histidyl-proline),Histidylproline diketopiperazine)
CAS: 53109-32-3
化学式: C11H14N4O2
| 中文名 | Cyclo(his-pro) |
| 英文名 | Cyclo(his-pro),Cyclo(histidyl-proline),Histidylproline diketopiperazine |
| 别名 | 环(组氨酰-脯氨酰) 化合物CYCLO(HIS-PRO) (3S,8AS)-六氢-3-(1H-咪唑-4-基甲基)吡咯并[1,2-A]吡嗪-1,4-二酮 |
| 英文别名 | Cyclo(his-pro) CYCLO(-HIS-PRO) HIS-PRO, CYCLIC Cyclo-Pro-His-HO Cyclo(histidyl-proline) CYCLO(HISTIDYL-PROLINE) histidylproline dioxopiperazine Histidylproline diketopiperazine HISTIDYLPROLINE DIKETOPIPERAZINE Cyclo(his-pro),Cyclo(histidyl-proline),Histidylproline diketopiperazine (3S,6S)-3-(3H-imidazol-4-ylmethyl)-1,4-diazabicyclo[4.4.0]decane-2,5-dione |
| CAS | 53109-32-3 |
| 化学式 | C11H14N4O2 |
| 分子量 | 234.25 |
| 密度 | 1.41±0.1 g/cm3(Predicted) |
| 熔点 | 162-164 °C |
| 沸点 | 659.3±48.0 °C(Predicted) |
| 酸度系数 | 12.73±0.40(Predicted) |
| 存储条件 | 2-8°C |
| 体外研究 | cyclo(his-pro) (Cyclo(histidyl-proline); 50 μM; 1-48 hours) increases the nuclear level of Nrf2 and inhibits NF-κB nuclear translocation. Cyclo(His-Pro) alone has no effect on nuclear translocation of these transcription factors. cyclo(his-pro) (50 μM; prior to PQ exposure for 48 hours) abolishes protein nitration that followed paraquat (PQ) exposure and lessenes its functional consequences, as shown by decrease in cell apoptosis, detected by caspase 3 activity and by cytochrome c release. Cyclo(his-pro) inhibits NF-κB nuclear accumulation induced by paraquat in rat pheochromocytoma PC12 cells via the Nrf2/heme oxygenase-1 pathway. Western Blot Analysis Cell Line: PC12 cells Concentration: 50 μM Incubation Time: 1, 2, 4, 8, 24, 48 hours Result: Increased the nuclear level of Nrf2 and inhibited NF-κB nuclear translocation. |
| 体内研究 | Cyclo(his-pro) (Cyclo(histidyl-proline); 1.8 mg/ear; topical application on the right ear; 30 min prior to TPA) reduces TPA-induced ear oedema confirming that it can exert anti-inflammatory effect. Cyclo(his-pro) exerts in vivo anti-inflammatory effects in the central nervous system by down-regulating hepatic and cerebral TNFα expression thereby counteracting LPS-induced gliosis. Moreover, by up-regulating Bip, Cyclo(his-pro) increases the ER stress sensitivity andtriggers the unfolded protein response to alleviate the ER stress. Animal Model: Sixty two/three month-old male C57BL/6 mice (25-30 g) Dosage: 1.8 mg/ear Administration: Topical application on the right ear; 30 min prior to TPA Result: Reduced TPA-induced ear oedema. |
| WGK Germany | 3 |
供应商列表
现货供应
产品名: 普罗瑞林杂质5 (普罗瑞林 EP 杂质 E) 去供应商网站查看 询盘CAS: 53109-32-3
产地: 中国-STD
包装: 支
规格: 10mg，25mg，50mg，100mg
价格: 电询
库存: 现货
电话: 0714-3999186
手机: 15671228036
电子邮件: 2853786052@qq.com
QQ: 2853786052
微信: 15671228036
产品描述: 10025P
现货供应
产品名: Cyclo(his-pro) 去供应商网站查看 询盘CAS: 53109-32-3
产地: 中国上海
包装: 25mg
规格: 98%
价格: 2898.00
库存: 现货
电话: 400-900-4166
手机: 18017137653
电子邮件: 3007523013@qq.com
QQ: 3007523013
微信: 18017137653
产品描述: 中文名：Cyclo(his-pro) 英文名:Cyclo(his-pro) CAS:53109-32-3 规格:98% 产地:中国上海
现货供应
产品名: 普罗瑞林杂质5 (普罗瑞林 EP 杂质 E) 去供应商网站查看 询盘CAS: 53109-32-3
产地: 中国-STD
包装: 支
规格: 10mg，25mg，50mg，100mg
价格: 电询
库存: 现货
电话: 0714-3999186
手机: 15671228036
电子邮件: 2853786052@qq.com
QQ: 2853786052
微信: 15671228036
产品描述: 10025P
现货供应
产品名: Cyclo(his-pro) 去供应商网站查看 询盘CAS: 53109-32-3
产地: 中国上海
包装: 25mg
规格: 98%
价格: 2898.00
库存: 现货
电话: 400-900-4166
手机: 18017137653
电子邮件: 3007523013@qq.com
QQ: 3007523013
微信: 18017137653
产品描述: 中文名：Cyclo(his-pro) 英文名:Cyclo(his-pro) CAS:53109-32-3 规格:98% 产地:中国上海
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