87233-61-2
依美司丁(Emedastine)
CAS: 87233-61-2
化学式: C17H26N4O
| 中文名 | 依美司丁 |
| 英文名 | Emedastine |
| 别名 | 依美司丁 依美斯汀 依美斯汀杂质D 依美斯汀杂质E 依美斯汀杂质F 依美斯汀杂质B 依美斯汀杂质C 1-(2-乙氧基乙基)-2-(4-甲基-1,4-二氮杂庚烷-1-基)苯并咪唑 |
| 英文别名 | Rapimine Emedastine EMEDASTINE 87233-61-2 Emedastine impurity F 1-(2-Ethoxyethyl)-2-(4-methyl-1,4-diazepan-1-yl)benzimidazole 1-[2-(Ethoxy)ethyl]-2-(4-methyl-1-homopiperazinyl)benzimidazole 1-(2-Ethoxyethyl)-2-(4-methyl-1,4-diazepan-1-yl)-1H-benzimidazole 1-(2-ethoxyethyl)-2-(4-Methyl-1,4-diazepan-1-yl)-1H-1,3-benzodiazole 1-(2-ethoxyethyl)-2-(4-methyl-1,4-diazepan-1-yl)-1H-benzo[d]imidazole 1-(2-Ethoxyethyl)-2-(4-methylhexahydro-1H-1,4-diazepine-1-yl)-1H-benzimidazole 1-(2-Ethoxyethyl)-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-1H-benzimidazole 1H-benzimidazole, 1-(2-ethoxyethyl)-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)- 1-(2-Ethoxyethyl)-2-[(hexahydro-4-methyl-1H-1,4-diazepin)-1-yl]-1H-benzimidazole |
| CAS | 87233-61-2 |
| EINECS | 200-258-5 |
| 化学式 | C17H26N4O |
| 分子量 | 302.41 |
| InChI | InChI=1/C17H26N4O/c1-3-22-14-13-21-16-8-5-4-7-15(16)18-17(21)20-10-6-9-19(2)11-12-20/h4-5,7-8H,3,6,9-14H2,1-2H3 |
| 密度 | 1.15±0.1 g/cm3(Predicted) |
| 沸点 | 446.6±55.0 °C(Predicted) |
| 闪点 | 223.9°C |
| 蒸汽压 | 3.59E-08mmHg at 25°C |
| 折射率 | 1.594 |
| 酸度系数 | 8.86±0.10(Predicted) |
| 存储条件 | 2-8°C |
| 体外研究 | Emedastine inhibits histamine H 2 receptor (K i =49067 nM) and histamine H 3 receptor (K i =12430 nM). High concentrations of Emedastine (1 and 10 ng/ml) significantly inhibits type 1 collagen production in normal human dermal fibroblasts. Emedastine (1, 10, 100, 1000 nM) at concentrations of ≥ 10 nM inhibits CC chemokine-elicited eosinophil migration. |
| 体内研究 | Emedastine (0.03, 0.1, 0.3 mg/kg; orally; pretreatment of 30 min) significantly suppresses histamine-induced scratching with 0.1 and 0.3 mg/kg but not 0.03 mg/kg. Pretreatment with Emedastine (0.03, 0.1, 0.3 mg/kg; orally) significantly inhibits the scratching induced by substance P and leukotriene B. Emedastine (0.3 mg/kg, p.o.) produces significant inhibition of passive peritoneal anaphylaxis in guinea-pigs. Emedastine inhibits histamine-induced contractions of isolated ileum (IC 50 =6.1 nM). Animal Model: Male ICR mice 5-6 weeks of age Dosage: 0.03, 0.1, 0.3 mg/kg Administration: Orally; 30 min before pruritogen injection Result: Significantly suppressed histamine-induced scratching with pretreatment of 0.1 and 0.3 mg/kg. |
| 上游原料 | N1-(2-乙氧基乙基)苯-1,2-二胺 依美司汀 EP 杂质 E 1,4-二氮杂环庚烷-1-甲酸叔丁酯 N-甲基高哌嗪 2-氯苯并咪唑 苯胺 |
87233-61-2 - 配置溶液浓度参考
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.307 ml | 16.534 ml | 33.068 ml |
| 5 mM | 0.661 ml | 3.307 ml | 6.614 ml |
| 10 mM | 0.331 ml | 1.653 ml | 3.307 ml |
| 5 mM | 0.066 ml | 0.331 ml | 0.661 ml |
最后更新：2024-01-02 23:10:35
供应商列表
现货供应
产品名: Emedastine 去供应商网站查看 询盘CAS: 87233-61-2
产地: 上海
规格: 98%
价格: 5mg 480,10mg 720,25mg 1280,50mg 2400,100mg 4480
库存: 现货
电话: 18301782025
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产品描述: Emedastine 98% MedMol 货号：S88203
现货供应
产品名: Emedastine 去供应商网站查看 询盘CAS: 87233-61-2
产地: 上海
规格: 98%
价格: 5mg 480,10mg 720,25mg 1280,50mg 2400,100mg 4480
库存: 现货
电话: 18301782025
手机: 18301782025
电子邮件: 3008007403@qq.com
QQ: 3008007403
微信: 18301782025
产品描述: Emedastine 98% MedMol 货号：S88203
87233-61-2的上游原料
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