中文名 | D-蛋氨酸 |
英文名 | D-Methionine |
别名 | D-蛋氨酸 D-甲硫基丁氨酸 D-甲硫氨酸(D-蛋氨酸) D-2-氨基-4-甲硫基丁酸 D-METHIONINE D-蛋氨酸 D-甲硫氨酸,D-2-氨基-4-甲硫基丁酸 |
英文别名 | H-D-Met-OH D-LOBAMINE H-D-MET-OH D-Methionine D-METHIONINE D-BANTHIONINE d-2-amino-4-(methylthio)butyric acid D-2-AMINO-4-[METHYLTHIO]BUTANOIC ACID (R)-2-AMINO-4-(METHYLMERCAPTO)BUTYRIC ACID (r)-2-amino-4-(methylmercapto)butyric acid (2R)-2-Amino-4-methylsulfanylbutanoic acid |
CAS | 348-67-4 |
EINECS | 206-483-6 |
化学式 | C5H11NO2S |
分子量 | 149.21 |
InChI | InChI=1/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m1/s1 |
密度 | 1.113 (estimate) |
熔点 | 273-275 °C |
沸点 | 306.9±37.0 °C(Predicted) |
比旋光度 | -24 º (c=8, 6N HCl) |
闪点 | 139.4°C |
水溶性 | 53 g/L (20 ºC) |
蒸汽压 | 0.00017mmHg at 25°C |
溶解度 | 53g/L (20 °C) |
折射率 | 1.5216 (estimate) |
酸度系数 | 2.23±0.10(Predicted) |
存储条件 | Sealed in dry,Room Temperature |
稳定性 | 稳定。与强氧化剂不相容。 |
外观 | 粉末 |
颜色 | White to off-white |
Merck | 14,5975 |
BRN | 1722293 |
物化性质 | D-蛋氨酸为白色结晶。溶于水、稀酸及碱,极微溶于醇,不溶于醚。 |
MDL号 | MFCD00002622 |
体外研究 | The incubation of human plasma with Methionine (D-methionine) and CP leads to the formation of a Pt-D-methionine complex independent of the order of addition. In plasma, an early CP hydrolysis product reacts with Methionine to form a 1:1 complex that is followed by the formation of a 2:1 compound at a later time point. The formation of these Pt-D-methionine species plays an important role in the processes by which Methionine protects mammalian organisms against CP-induced toxicities. |
体内研究 | When Methionine (D-methionine) is administered along with cisplatin the cell density is 0.8±0.070 (SEM), significantly larger than in rats treated with only cisplatin (P<0.01) while not significantly different from controls or from animals treated only with D-methionine (P>0.05). When Methionine is administered alone the average cell density is 0.95±0.099 (SEM) and not significantly different from controls (P>0.05). |
危险品标志 | Xi - 刺激性物品 |
风险术语 | R33 - 有累积效应的危险品。 R36/37/38 - 刺激眼睛、呼吸系统和皮肤。 |
安全术语 | S22 - 切勿吸入粉尘。 S24/25 - 避免与皮肤和眼睛接触。 S36 - 穿戴适当的防护服。 S26 - 不慎与眼睛接触后,请立即用大量清水冲洗并征求医生意见。 |
WGK Germany | 3 |
RTECS | PD0455000 |
TSCA | Yes |
海关编号 | 29304090 |
上游原料 | DL-蛋氨酸 N-甲酰基-DL-蛋氨酸 N-甲酰-D-蛋氨酸 N,N-二甲基甘氨酸 甲醛 肌氨酸 |
下游产品 | 甲基硫代乙酸 |
参考资料 展开查看 | 1. [IF=3.935] Min Zhang et al."Chemical profile and miscarriage prevention evaluation of Jiao-ai decoction, a classical traditional Chinese formula."JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS. 2022 May;:114832 |
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