Digeranyl bisphosphonate

中文名	Digeranyl bisphophonate (DGBP)
英文名	Digeranyl bisphophonate (DGBP)
别名	化合物 T12452
英文别名	DGBP 878143-03-4 Digeranyl bisphophonate Digeranyl bisphosphonate Digeranyl bisphophonate (DGBP) Phosphonic acid, [(3E)-1-[(2E)-3,7-dimethyl-2,6-octadienyl]-4,8-dimethyl-3,7-nonadienylidene]bis-, tetrasodium salt
CAS	878143-03-4
化学式	C21H34Na4O6P2
分子量	536.397662
存储条件	-20°C，密闭，干燥
体外研究	Digeranyl bisphosphonate (DGBP) impairs geranylgeranylation. To examine if Digeranyl bisphosphonate modulates Rac1 activity, cells are exposed to vehicle or Digeranyl bisphosphonate. Rac1 activation increases significantly after chrysotile exposure, whereas the activity in Digeranyl bisphosphonate -treated cells is reduced to control levels. Digeranyl bisphosphonate also decreases H 2 O 2 generation in chrysotile-exposed macrophages.
体内研究	To further evaluate the effect of Digeranyl bisphosphonate (DGBP; 0.2 mg/kg/day) in protecting mice from chrysotile-induced pulmonary fibrosis, the mice are administered vehicle or Digeranyl bisphosphonate subcutaneously in osmotic pumps, and exposed to saline or chrysotile the following day. Mice exposed to saline have normal lung architecture with vehicle and Digeranyl bisphosphonate treatment. Chrysotile-exposed mice that receive vehicle have significant architectural changes in their lung parenchyma and large amounts of collagen deposition, whereas the lungs of the Digeranyl bisphosphonate -treated mice are essentially normal. To investigate the effect of Digeranyl bisphosphonate in Bleomycin-induced fibrosis, osmotic pumps containing either vehicle or Digeranyl bisphosphonate are implanted subcutaneously in WT mice. Mice are exposed to saline or Bleomycin the following day. Digeranyl bisphophonate (0.2 mg/kg/day)-treated mice show significantly less hydroxyproline compared to vehicle-treated mice exposed to Bleomycin.

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产品名: Digeranyl bisphosphonate 去供应商网站查看询盘
CAS: 878143-03-4
产地: 中国上海
包装: 10mg
规格: 95%
价格: 12238.00
库存: 现货
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产品描述: 中文名：Digeranyl bisphosphonate 英文名:Digeranyl bisphosphonate CAS:878143-03-4 规格:95% 更多

上海麦克林生化科技股份有限公司

现货供应

产品名: Digeranyl bisphophonate (DGBP) 去供应商网站查看询盘
CAS: 878143-03-4
产地: 上海
规格: D911577
价格: 1mg-3421
库存: 7天内发货
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