GYY 4137 MORPHOLINE SALT

中文名	GYY 4137 MORPHOLINE SALT
英文名	GYY 4137 Morpholine salt
别名	4-甲氧基苯基硫代磷酸酯(吗啉)吗啉盐 (4-甲氧基苯基)吗啉基-二硫代膦酸与吗啉的化合物化合物GYY 4137 MORPHOLINE SALT 4-甲氧基苯基硫代磷酸酯(吗啉)吗啉盐 4-METHOXYPHENYL(MORPHOLINO)PHOSPHINODITHIOATE MORPHOLINIUM SALT
英文别名	GYY4137 GYY 4137 GYY-4137 GYY 4137 MORPHOLINE SALT GYY 4137 Morpholine salt morpholin-4-ium (4-methoxyphenyl)(morpholino)phosphinodithioate 4-Methoxyphenyl(morpholino)phosphinodithioate morpholinium salt P-(4-Methoxyphenyl)-P-4-morpholinylphosphinodithioic acid morpholine salt (4-Methoxyphenyl)morpholino-phosphinodithioic acid compound with morpholine (4-methoxyphenyl)-morpholin-4-yl-sulfanylidene-sulfido-λ5-phosphane,morpholin-4-ium
CAS	106740-09-4
化学式	C15H25N2O3PS2
分子量	376.474361
熔点	164-166℃
存储条件	2-8℃
外观	白色固体。
体外研究	GYY4137 (400-800 µM) causes concentration-dependent killing of seven different human cancer cell lines (HeLa, HCT-116, Hep G2, HL-60, MCF-7, MV4-11 and U2OS) but did not affect survival of normal human lung fibroblasts (IMR90, WI-38). GYY4137 (0.1-0.5 mM) decreases LPS-induced production of nitrite (NO2−), PGE2, TNF-α and IL-6 from human synoviocytes (HFLS) and articular chondrocytes (HAC), reduces the levels and catalytic activity of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) and reduced LPS-induced NF-κB activation. Cell Viability Assay Cell Line: HeLa, HCT-116, Hep G2, HL-60, MCF-7, MV4-11 and U2OS Concentration: 400 or 800 µM Incubation Time: 5 days Result: Significantly affected cancer cell survivability.
体内研究	GYY4137 (100-300 mg/kg; i.p.; daily for 14 days) significantly reduces the tumor volume in both animal models, in a dose-dependent manner. In the complete Freund's adjuvant (CFA)-treated mouse, GYY4137 (50 mg/kg, i.p.) injected 1 hr prior to CFA increased knee joint swelling while an anti-inflammatory effect, as demonstrated by reduced synovial fluid myeloperoxidase (MPO) and N-acetyl-β-D-glucosaminidase (NAG) activity and decreased TNF-α, IL-1β, IL-6 and IL-8 concentration, was apparent when GYY4137 was injected 6 hrs after CFA. GYY4137 significantly inhibited tumor growth in the subcutaneous HepG2 xenograft model by inhibiting STAT3 activation and its target gene expression. GYY4137 prevents nitrative stress and α-synuclein nitration in an MPTP mouse model of parkinson’s disease. Animal Model: Female, severe combined immunodeficiency (SCID) mice (bearing HL-60 or MV4-11 cells) Dosage: 100, 200 and 300 mg/kg Administration: I.p.; daily for 14 days Result: Reduced tumor volume by 52.5±9.2% and 55.3±5.7% in HL-60 and MV4–11 injected animals.

北京索莱宝科技有限公司

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产品名: GYY4137 去供应商网站查看询盘
CAS: 106740-09-4
产地: 北京
包装: 5mg/瓶;
规格: IG4530-5mg
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上海吉至生化科技有限公司

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产品名: GYY4137 去供应商网站查看询盘
CAS: 106740-09-4
产地: 中国上海
包装: 10mg
规格: 98%
价格: 1998.00
库存: 现货
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产品描述: 中文名：GYY4137 英文名:GYY4137 CAS:106740-09-4 规格:98% 产地:中国上海

上海麦克林生化科技股份有限公司

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产品名: GYY4137 morpholine salt 去供应商网站查看询盘
CAS: 106740-09-4
产地: 上海
规格: G795739
价格: 1ml-688,10mg-988,100mg-4488
库存: 现货
电话: 13816333479/17821173903
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上海源叶生物科技有限公司

产品名: GYY 4137 MORPHOLINE SALT 去供应商网站查看询盘
CAS: 106740-09-4
产地: 上海
规格: 98%
价格: 10mg 3370
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