KHS101 hydrochloride
KHS101 hydrochloride(KHS101 hydrochloride)
CAS: 1784282-12-7
化学式: C18H22ClN5S
| 中文名 | KHS101 hydrochloride |
| 英文名 | KHS101 hydrochloride |
| 别名 | 盐酸KHS101 |
| 英文别名 | KHS101 hydrochloride |
| CAS | 1784282-12-7 |
| 化学式 | C18H22ClN5S |
| 分子量 | 375.92 |
| 溶解度 | 溶于DMSO |
| 存储条件 | -20℃ |
| 靶点 | TACC3 |
| 体外研究 | KHS101 increases neuronal differentiation of adherently cultured rat NPCs in a dose-dependent fashion (EC 50 ~1 μM). KHS101-induced neuron formation (40-60% TuJ1+ cells at 1.5–5 μM KHS101) is also observed under neurosphere-forming conditions in secondary neurospheres derived from both the hippocampus and the subventricular zone (SVZ) of adult rats. Moreover, hippocampal NPCs treated with KHS101 and cultured adherently on microelectrode arrays for 12 d exhibit neuronal morphologies as well as spontaneous spiking activity, hence indicating the presence of functional, maturing neurons. KHS101 markedly attenuates tumor cell growth as compared to the cells treated with the vehicle [dimethyl sulfoxide (DMSO)]. TACC3 is a known target of KHS101 in rodent neural progenitor cells. KHS101 has been shown to cause cellular destabilization of TACC3, hence reducing endogenous TACC3 protein levels over time . |
| 体内研究 | Tumor cell proliferation is markedly reduced in KHS101-treated tumors (about twofold). KHS101-treated tumors show signs of elevated cell death (reduced cellularity/increased pyknosis) compared with tumors treated with vehicle control. KHS101 treatment markedly reduces both frontal-to-caudal tumor expansion and corpus callosum invasion of vimentin-positive GBM1 cells. It is also found that the survival of animals carrying GBMX1 tumors (established 2 or 6 weeks before treatment) is markedly increased by the KHS101 treatment regimen for 10 weeks. None of the mice have to be removed from the study because of adverse side effects of the treatment. An additional experiment using a continuous KHS101 treatment regimen until the experimental endpoints also shows a marked increase in the survival of GBMX1-bearing animals. Histological endpoint analysis of KHS101- and vehicle-treated animals confirms a significantly decreased tumor size in KHS101-treated mice. |
| 参考资料 展开查看 | 1: Pawar V, Srivastava R. Chitosan-Polycaprolactone Blend Sponges for Management of Chronic Osteomyelitis: A Preliminary Characterization and In vitro Evaluation. Int J Pharm. 2019 Jul 22:118553. doi: 10.1016/j.ijpharm.2019.118553. [Epub ahead of print] PubMed PMID: 31344444. 2: Xu Q, Li Y, Jing Y, Lv N, Wang L, Li Y, Yu L. Epigenetic modifier gene mutations-positive AML patients with intermediate-risk karyotypes benefit from decitabine with CAG regimen. Int J Cancer. 2019 Jul 25. doi: 10.1002/ijc.32593. [Epub ahead of print] PubMed PMID: 31344264. 3: Ohno K, Zhao C, Nishina Y. Polymer-Brush-Decorated Graphene Oxide: Precision Synthesis and Liquid-Crystal Formation. Langmuir. 2019 Jul 25. doi: 10.1021/acs.langmuir.9b01747. [Epub ahead of print] PubMed PMID: 31343884. 4: deVries T, Dentiste A, Di Lea C, Pichette V, Jacobs D. Effects of Renal Impairment on the Pharmacokinetics of Once-Daily Amantadine Extended-Release Tablets. CNS Drugs. 2019 Jul 24. doi: 10.1007/s40263-019-00651-1. [Epub ahead of print] PubMed PMID: 31342404. |
KHS101 hydrochloride - 配置溶液浓度参考
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.66 ml | 13.301 ml | 26.602 ml |
| 5 mM | 0.532 ml | 2.66 ml | 5.32 ml |
| 10 mM | 0.266 ml | 1.33 ml | 2.66 ml |
| 5 mM | 0.053 ml | 0.266 ml | 0.532 ml |
最后更新：2024-01-02 23:10:35
KHS101 hydrochloride - 细胞实验
Rat NPCs were derived and cultured as described previously by others. After hippocampal cell isolation, the number of dissociated cells was determined and ?5 × 10^5 cells were plated in 60-mm uncoated plates. After overnight incubation (37 °C, 5% CO2, and 95% humidity), the medium was changed and the cells were expanded and maintained in an undifferentiated state on polyornithine- (10 μg/mL in water) and laminin-coated (5 μg/mL in PBS;) dishes in DMEM/F12 supplemented with N2 and basic fibroblast growth factor (bFGF, 20 ng/mL;). For KHS101 and shRNA-induction experiments, early passage cells (passaged no more than six times after hippocampal isolation) were trypsinized and plated at a density of ?1,000 cells/cm2 into N2 medium (DMEM/F12 supplemented with N2) containing KHS analogs (e.g., KHS101, KHS92, and NP; SI Text) at different concentrations (0.5–5 μM) or DMSO (0.1%), RA (1–2 μM), BDNF (100 ng/mL), and/or BMP4 (50–100 ng/mL) for 4 d .
最后更新：2023-08-16 21:32:38
KHS101 hydrochloride - 动物实验
To investigate the pharmacokinetic properties of KHS101, male Sprague–Dawley rats were administered 3 mg/kg KHS101 i.v. or s.c. One rat was killed per time point at 5 min, 40 min, 1 h, and 3 h after dosing, and samples of blood (100 μL) and whole brains were collected. In a separate study, rats were administered 6 mg/kg KHS101 i.v. or s.c. Five blood samples of 100 μL each were collected serially via a jugular vein catheter at 2 min (i.v. only), 0.5 h (s.c. only), and 1, 3, 7 and 24 h after dosing. Plasma and homogenized whole brain samples were analyzed by liquid chromatography-tandem mass spectrometry (LC-MS/MS). To study neuronal differentiation upon KHS101 administration in vivo, adult Fisher 344 rats (?10 wk old) received s.c. injections of 6 mg/kg KHS101 or vehicle control (5% ethanol in 15% Captisol). All rats received one daily i.p. injection of 200 mg/kg BrdU for 6 consecutive days after the first day. After 14 d, the animals were killed and perfusion fixed, and the brains were removed and subjected
最后更新：2023-08-16 21:32:38
KHS101 hydrochloride - 简介
KHS101 hydrochloride是一种化合物。以下是关于KHS101 hydrochloride的性质、用途、制法和安全信息的介绍：
性质：
- 外观：KHS101 hydrochloride以白色结晶固体形式存在。
- 溶解性：可溶于水和一些有机溶剂。
用途：
制法：
- KHS101 hydrochloride的制备方法较为复杂，一般是通过一系列有机合成步骤来合成。
安全信息：
- 在操作KHS101 hydrochloride时，需要遵守化学实验室的安全操作规程，佩戴适当的防护设备，如手套、眼镜和实验室外套。
- 避免吸入粉尘或溶液，避免直接接触皮肤和眼睛。
- 在使用前先阅读供应商提供的安全数据表，并遵循相关的安全标签和说明。
性质：
- 外观：KHS101 hydrochloride以白色结晶固体形式存在。
- 溶解性：可溶于水和一些有机溶剂。
用途：
制法：
- KHS101 hydrochloride的制备方法较为复杂，一般是通过一系列有机合成步骤来合成。
安全信息：
- 在操作KHS101 hydrochloride时，需要遵守化学实验室的安全操作规程，佩戴适当的防护设备，如手套、眼镜和实验室外套。
- 避免吸入粉尘或溶液，避免直接接触皮肤和眼睛。
- 在使用前先阅读供应商提供的安全数据表，并遵循相关的安全标签和说明。
最后更新：2024-04-09 02:00:15
供应商列表
现货供应
产品名: KHS-101Hydrochloride 去供应商网站查看 询盘CAS: 1784282-12-7
产地: 北京
包装: 盒
规格: IK0510-5mg,5mg,IK0510-10mg,10mg
价格: 电话、微信、QQ、邮件
库存: 现询
电话: 010-50973130
手机: 17801761073(微信同号)
电子邮件: 3193328036@qq.com
QQ: 3193328036
微信: 17801761073
产品描述: 索莱宝直销，欢迎来询
现货供应
产品名: KHS101 hydrochloride 去供应商网站查看 询盘CAS: 1784282-12-7
产地: 上海
规格: K881299
价格: 5mg-823,10mg-1210,1ml-720
库存: 现货
电话: 13816333479/17821173903
手机: 13816333479/17821173903
电子邮件: wangrui@macklin.cn
QQ: 2885703204/288570320
微信: 19863730987/17821173903
现货供应
产品名: KHS101 hydrochloride 去供应商网站查看 询盘CAS: 1784282-12-7
产地: 上海
规格: ≥99%
价格: 5mg 500,10mg 800,25mg 1600,100mg 4800
库存: 现货
电话: 18301782025
手机: 18301782025
电子邮件: 3008007403@qq.com
QQ: 3008007403
微信: 18301782025
产品描述: KHS101 hydrochloride ≥99% MedMol 货号：T23329
现货供应
产品名: KHS-101Hydrochloride 去供应商网站查看 询盘CAS: 1784282-12-7
产地: 北京
包装: 盒
规格: IK0510-5mg,5mg,IK0510-10mg,10mg
价格: 电话、微信、QQ、邮件
库存: 现询
电话: 010-50973130
手机: 17801761073(微信同号)
电子邮件: 3193328036@qq.com
QQ: 3193328036
微信: 17801761073
产品描述: 索莱宝直销，欢迎来询
现货供应
产品名: KHS101 hydrochloride 去供应商网站查看 询盘CAS: 1784282-12-7
产地: 上海
规格: K881299
价格: 5mg-823,10mg-1210,1ml-720
库存: 现货
电话: 13816333479/17821173903
手机: 13816333479/17821173903
电子邮件: wangrui@macklin.cn
QQ: 2885703204/288570320
微信: 19863730987/17821173903
现货供应
产品名: KHS101 hydrochloride 去供应商网站查看 询盘CAS: 1784282-12-7
产地: 上海
规格: ≥99%
价格: 5mg 500,10mg 800,25mg 1600,100mg 4800
库存: 现货
电话: 18301782025
手机: 18301782025
电子邮件: 3008007403@qq.com
QQ: 3008007403
微信: 18301782025
产品描述: KHS101 hydrochloride ≥99% MedMol 货号：T23329
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